s-benzyl-n-acetyl-l-cysteine profile

S-benzyl-N-acetyl-L-cysteine (SNAC) is a synthetic derivative of the amino acid L-cysteine. It is a potent antioxidant and free radical scavenger that has been shown to protect cells from oxidative damage. SNAC is also a prodrug of N-acetyl-L-cysteine (NAC), which is a well-known mucolytic agent used to treat respiratory conditions such as chronic obstructive pulmonary disease (COPD). SNAC has been studied for its potential therapeutic applications in a variety of diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. SNAC is synthesized by reacting L-cysteine with benzyl bromide in the presence of a base. The resulting product is then acetylated to yield SNAC. SNAC is a promising therapeutic agent with a wide range of potential applications. However, further research is needed to fully understand its efficacy and safety in humans.'
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S-benzyl-N-acetyl-L-cysteine: RN given refers to (L)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-acetyl-S-benzyl-L-cysteine : The S-benzyl derivative of N-acetyl-L-cysteine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	107816
CHEBI ID	165854
SCHEMBL ID	7282451
MeSH ID	M0093570

Synonym
sbnac
19542-77-9
benzylmercapturic acid
CHEBI:165854
(2r)-2-acetamido-3-benzylsulanylpropanoic acid
n-acetyl-s-benzyl-l-cysteine
(2r)-2-acetamido-3-benzylsulfanylpropanoic acid
unii-x3h719rfpt
l-cysteine, n-acetyl-s-(phenylmethyl)-
s-benzylmercapturic acid
s-benzyl-n-acetyl-l-cysteine
x3h719rfpt ,
2r)-2-acetamido-3-(phenylmethylsulfanyl)propanoic acid
SCHEMBL7282451
(r)-2-acetamido-3-(benzylthio)propanoic acid
AKOS024306968
AC-29503
n -acetyl-s-(benzyl)-l-cysteine
F31244
DS-9210
DTXSID90894753
Q4890819
mfcd00038237
n-acetyl-s-benzyl-l-cysteine (ac-l-cys(bzl)-oh)
(2r)-2-acetamido-3-benzylsulfanyl-propanoic acid
CS-0154009
(2r)-3-(benzylsulfanyl)-2-acetamidopropanoic acid
n-acetyl-s-(phenylmethyl)-l-cysteine; n-acetyl-3-(benzylthio)-alanine; benzylmercapturic acid; acetyl benzyl cysteine; s-benzylmercapturic acid;

Excerpt	Relevance	Reference
" Male Fischer 344 rats were dosed by gavage with [methylene-14C]benzyl acetate (500 mg/kg) alone or together with pyrazole (200 mg/kg), pentachlorophenol (10 mg/kg) or both pentachlorophenol (10 mg/kg) and pyrazole (200 mg/kg), given in each case ip."	( Studies on benzyl acetate. II. Use of specific metabolic inhibitors to define the pathway leading to the formation of benzylmercapturic acid in the rat. Caldwell, J; Chidgey, MA; Kennedy, JF, 1986)	0.27
" First, the efficacy of the acivicin treatment was established from a dose-response investigation in which urinary gamma-GT was measured daily in rats exposed to 1750 ppm toluene, 6 h per day for five days."	( Toluene-induced hearing loss in acivicin-treated rats. Campo, P; Cosnier, F; Cossec, B; Ferrari, L; Grossman, S; Waniusiow, D, )	0.13

Role	Description
human urinary metabolite	Any metabolite (endogenous or exogenous) found in human urine samples.
rat metabolite	Any mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
S-substituted N-acetyl-L-cysteine
organic sulfide	Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (17.24)	18.7374
1990's	5 (17.24)	18.2507
2000's	10 (34.48)	29.6817
2010's	5 (17.24)	24.3611
2020's	4 (13.79)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.78%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	35 (97.22%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	3.08	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
benzaldehyde [no description available]	1.97	1	benzaldehydes	EC 3.1.1.3 (triacylglycerol lipase) inhibitor; EC 3.5.5.1 (nitrilase) inhibitor; flavouring agent; fragrance; odorant receptor agonist; plant metabolite
benzene [no description available]	3.06	4	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
2-cresol 2-cresol: RN given refers to parent cpd. o-cresol : A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.	2.43	2	cresol	human xenobiotic metabolite
hippuric acid hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591. N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.	2.42	2	N-acylglycine	human blood serum metabolite; uremic toxin
pentachlorophenol PENTA: structure given in first source	1.96	1	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite
pyrazole 1H-pyrazole : The 1H-tautomer of pyrazole.	1.96	1	pyrazole
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	3.67	9	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	2	1	pentacarboxylic acid	copper chelator
probenecid Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.	1.96	1	benzoic acids; sulfonamide	uricosuric drug
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	3.08	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	1.97	1	nitrosamine	geroprotector; mutagen
thiophenol thiophenol : A thiol in which the sulfanyl group is attached to a phenyl group.	2.01	1	aryl thiol
benzyl acetate benzyl acetate : The acetate ester of benzyl alcohol.	1.96	1	acetate ester; benzyl ester	metabolite
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	5.77	28	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
nitrosobenzylmethylamine nitrosobenzylmethylamine: structure	1.97	1
dysprosium Dysprosium: An element of the rare earth family that has the atomic symbol Dy, atomic number 66, and atomic weight 162.50. Dysprosium is a silvery metal used primarily in the form of various salts.	2	1	f-block element atom; lanthanoid atom
(2-methoxyethoxy)acetic acid (2-methoxyethoxy)acetic acid: a urinary biomarker; metabolite of 2-(2-methoxyethoxy)ethanol	2.07	1
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.07	1	benzenes; phenyl acetates
monobromobimane monobromobimane: fluorescent when reacted with thiol group; RN & N1 from CA Vol 91 Form Index; inhibits platelet calcium-dependent protease activity & the ability of dibucaine-stimulated platelets to support factor X activation; structure in first source. monobromobimane : A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing three methyl substituents at positions 2, 5 and 6 as well as a bromomethyl substituent at the 3-position.	2	1	organobromine compound; pyrazolopyrazole	fluorochrome
3-nitrotyrosine 3-nitrotyrosine: RN given refers to parent cpd without isomeric designation. 3-nitrotyrosine : A nitrotyrosine comprising tyrosine having a nitro group at the 3-position on the phenyl ring.	3.08	1	2-nitrophenols; C-nitro compound; nitrotyrosine; non-proteinogenic alpha-amino acid
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.21	1	cyclodextrin
acetyl coenzyme a Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.	1.98	1	acyl-CoA	acyl donor; coenzyme; effector; fundamental metabolite
sorbic acid Sorbic Acid: Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.. (2E,4E)-hexa-2,4-dienoic acid : A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometric isomers possible, as well as the one with the highest antimicrobial activity.. sorbic acid : A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.	2.02	1	alpha,beta-unsaturated monocarboxylic acid; sorbic acid
s-phenyl-n-acetylcysteine S-phenyl-N-acetylcysteine: found in urine of rats exposed to benzene; RN given refers to (L)-isomer; RN for cpd without isomeric designation not available 4/88	3.84	11	aryl sulfide; S-substituted N-acetyl-L-cysteine	biomarker; human urinary metabolite
zinostatin Zinostatin: An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.	2.01	1
muconic acid muconic acid: a metabolite of benzene; reported to be a reliable indicator of occupational exposure to benzene; structure given in first source. trans,trans-muconic acid : The trans,trans-isomer of muconic acid. It is metabolite of benzene in humans and serves as a biomarker of occupational exposure to benzene.. muconic acid : A hexadienedioic acid with unsaturation at positions 2 and 4.	2.02	1	muconic acid	biomarker; human xenobiotic metabolite
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.33	2	cysteinium	fundamental metabolite
abscisic acid Abscisic Acid: Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.. (S)-2-trans-abscisic acid : A 2-trans-abscisic acid with (S)-configuration at the chiral centre.. (+)-abscisic acid : The naturally occurring (1'S)-(+) enantiomer of abscisic acid. It is an important sesquiterpenoid plant hormone which acts as a regulator of plant responses to environmental stresses such as drought and cold.	2.6	1	2-trans-abscisic acid

Condition	Relationship Strength	Studies
Hypertriglyceridemia A condition of elevated levels of TRIGLYCERIDES in the blood.	2.41	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.92	4
Chemical Dependence [description not available]	1.98	1
Substance-Related Disorders Disorders related to substance use or abuse.	1.98	1

s-benzyl-n-acetyl-l-cysteine

Description

Cross-References

Synonyms (28)

Research Excerpts

Dosage Studied

Roles (2)

Drug Classes (2)

Research

Studies (29)

Market Indicators

Research Demand Index: 11.10

Study Types