Compounds > glycol salicylate
Page last updated: 2024-12-05

glycol salicylate

Description

Glycol salicylate is a compound used in cosmetics and pharmaceuticals. It is synthesized by reacting salicylic acid with ethylene glycol. It is known for its anti-inflammatory and analgesic properties, and is used in topical creams and lotions to relieve pain and inflammation. Glycol salicylate is also used as a fragrance ingredient and as a solvent. Research on glycol salicylate focuses on its effectiveness as a topical anti-inflammatory agent, as well as its safety profile for human use. The compound is studied due to its potential benefits in treating skin conditions such as acne and eczema. '

glycol salicylate: component of Piadar; topical ointment of the above including 1% methanol in base [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-hydroxyethyl salicylate : A benzoate ester obtained by the formal condensation of carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6880
CHEMBL ID173562
CHEBI ID86541
SCHEMBL ID15402
MeSH IDM0075189

Synonyms (82)

Synonym
ethylene glycol monosalicylate
espirosal
.beta.-hydroxyethyl salicylate
ethylene glycol salicylate
salicylic acid, 2-hydroxyethyl ester
glysal
nsc-72097
rheumacyl
nsc72097
gl 7
glycol monosalicylate
2-hydroxyethyl salicylate
87-28-5
spirosal
sarocol
glycol salicylate
ethylene glycol, monosalicylate
monoglycol salicylate
1,2-ethylene glycol monosalicylate
ethylene glycol, salicylate
NCGC00159379-02
D01557
norgesic (tn)
glycol salicylate (jan)
phlogont (tn)
2-hydroxyethyl 2-hydroxybenzoate
inchi=1/c9h10o4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11h,5-6h2
lvylcbnxhhhpsb-uhfffaoysa-
aethylenglykolsalicylat
ethylenglycol-monosalicylsaeureester
2-hydroxybenzoic acid, 2-hydroxyethyl ester
benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
traumasenex
salicylic acid, 2-hydroxyethyl ester (8ci)
glykolsalicylat
kytta-gel
BMSE000750
phlogont
chebi:86541 ,
CHEMBL173562
E0113
salicylic acid 2-hydroxyethyl ester
A842078
NCGC00159379-03
dtxcid4028913
cas-87-28-5
dtxsid4048987 ,
tox21_113462
AKOS009075810
einecs 201-737-2
nsc 72097
unii-3i1vbb7axh
3i1vbb7axh ,
ai3-05033
FT-0626298
glycol salicylate [inci]
hydroxyethyl salicylate
glycol salicylate [mi]
hydroxyethyl salicylate [ep monograph]
glycol salicylate [jan]
glycol salicylate [mart.]
glycol salicylate [who-dd]
SCHEMBL15402
NCGC00159379-04
W-104034
2-hydroxybenzoic acid 2-hydroxyethyl ester
LVYLCBNXHHHPSB-UHFFFAOYSA-N
CS-B1707
2-hydroxyethyl 2-oxidanylbenzoate
mfcd00002862
sr-01000944719
SR-01000944719-1
ethylene glycol monosalicylate, >=98.0% (gc)
hydroxyethyl salicylate, european pharmacopoeia (ep) reference standard
DB11323
HY-B2208
Q117422
SY032913
2-hydroxyethyl-salicylate
E78954
EN300-22340
2-hydroxy-benzoicacid2-hydroxyethyl ester

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (2 Product(s))

Product Categories

Product CategoryProducts
Herbs, Botanicals & Homeopathy2

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Terry Naturally Traumaplant Comfrey Cream -- 1.76 ozTerry NaturallyHerbs, Botanicals & Homeopathycomfrey, glyceryl stearate, glycol salicylate, dimethicone, octyldodecanol, propylene glycol, sorbic acid2024-11-29 10:47:42
Terry Naturally Traumaplant Comfrey Cream -- 3.53 ozTerry NaturallyHerbs, Botanicals & Homeopathycomfrey, glyceryl stearate, glycol salicylate, dimethicone, isopropyl myristate, octyldodecanol, propylene glycol, sorbic acid2024-11-29 10:47:42

Drug Classes (3)

ClassDescription
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
primary alcoholA primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
salicylatesAny salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency5.35380.000221.22318,912.5098AID743036
estrogen nuclear receptor alphaHomo sapiens (human)Potency16.93010.000229.305416,493.5996AID743069
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID91568Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by strand transfer method at 100 micro g/mL (experiment 1)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
AID91565Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL (experiment 2)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
AID91564Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL (experiment 1)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
AID91569Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by strand transfer method at 100 micro g/mL (experiment 2)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (7.69)18.7374
1990's4 (30.77)18.2507
2000's2 (15.38)29.6817
2010's3 (23.08)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.94 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index54.12 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (40.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (15.38%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (23.08%)4.05%
Observational0 (0.00%)0.25%
Other8 (61.54%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.0710monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
menthol
Menthol: A monoterpene cyclohexanol produced from mint oils.		2.0710p-menthane monoterpenoid;
secondary alcohol		volatile oil component
camphor, (+-)-isomer
[no description available]		2.0710bornane monoterpenoid;
cyclic monoterpene ketone		plant metabolite
methyl salicylate
methyl salicylate: used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990. methyl salicylate : A benzoate ester that is the methyl ester of salicylic acid.		2.7530benzoate ester;
methyl ester;
salicylates		flavouring agent;
insect attractant;
metabolite
nicotinic acid benzyl ester
nicotinic acid benzyl ester: RN given refers to parent cpd; structure in Merck Index, 9th ed, #6344. benzyl nicotinate : A benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It has been used as a rubefacient.		1.9610benzyl estervasodilator agent
ethyl salicylate
ethyl salicylate: causes erythema after topical application as an aerosol; found in blood		2.5320hydroxybenzoic acid
salicylurate
salicylurate: RN given refers to parent cpd. salicyluric acid : An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.. salicylurate : A monocarboxylic acid anion that is the conjugate base of salicyluric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.		1.9910N-acylglycine;
secondary carboxamide		human xenobiotic metabolite;
uremic toxin
trolamine salicylate
Arthritis: Acute or chronic inflammation of JOINTS.		1.9910
dihydrocapsaicin
[no description available]		2.0710capsaicinoid
capsaicin
ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.		2.0710capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
esculin
[no description available]		1.9910beta-D-glucoside;
hydroxycoumarin		antioxidant;
metabolite
palitantin
palitantin: RN given refers to (2alpha,3beta(1E,3E),5alpha,6alpha)-isomer		1.9910
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		5.5692monohydroxybenzoateplant metabolite
4-hydroxycoumarin
2-hydroxychromone: structure		1.9910hydroxycoumarin
nsc 158393
NSC 158393: structure given in first source		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Contact Dermatitis
[description not available]		02.730
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.730
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.4420
Rheumatoid Arthritis
[description not available]		03.3711
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		03.3711
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