Compounds > proximicin a
Page last updated: 2024-11-13

proximicin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

proximicin A: antineoplastic agent isolated from Verrucosispora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24829330
CHEMBL ID561854
SCHEMBL ID16483685
MeSH IDM0522356

Synonyms (4)

Synonym
CHEMBL561854
proximicin a
SCHEMBL16483685
methyl n-[5-[(5-carbamoylfuran-3-yl)carbamoyl]furan-3-yl]carbamate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID425454Cytotoxicity against human HepG2 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
AID425453Cytotoxicity against human AGS cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
AID425455Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry letters, Jul-15, Volume: 19, Issue:14
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's7 (63.64)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.20 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.68 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
stallimycin
[no description available]		2.4520
netropsin
Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.		3.86110
furan
furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.		7.4520furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		carcinogenic agent;
hepatotoxic agent;
Maillard reaction product
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.08101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
resistoflavin
[no description available]		2.0810
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		2.0810chalcogen;
nonmetal atom		macronutrient
ribose
ribopyranose : The pyranose form of ribose.		2.110D-ribose;
ribopyranose
altemicidin
altemicidin: sulfamino given in first source; monoterpene alkaloid; isolated from Actinomycete		2.0810
marmycin a
marmycin A: cytotoxic compound from a marine sediment-derived actinomycete related to the genus Streptomyces; structure in first source		2.0810
proximicin b
proximicin B: antineoplastic agent isolated from Verrucosispora; structure in first source		3.3160
proximicin c
proximicin C: antineoplastic agent isolated from Verrucosispora; structure in first source		3.3160
streptochlorin
streptochlorin: inhibits both NF-kappaB activation and angiogenesis; isolated from marine Streptomyces; structure in first source		2.0810
heliomycin
heliomycin: Russian drug; antibiotic with antiviral properties isolated from Actinomyces flavochromogenes var. heliomycini; structure		2.0810
abyssomicin c
abyssomicin C: antibiotic; structure in first source		2.0610
echinosporin
echinosporin: from Streptomyces echinosporus MK-213; structure given in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease
[description not available]		02.0710
Benign Neoplasms
[description not available]		02.0710
Bacterial Infections
Infections by bacteria, general or unspecified.		02.0710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0710