Compounds > exfoliazone
Page last updated: 2024-11-07

exfoliazone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

exfoliazone: from Streptomyces exfoliatus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131529
CHEMBL ID2311997
MeSH IDM0183950

Synonyms (6)

Synonym
acetamide, n-(8-(hydroxymethyl)-3-oxo-3h-phenoxazin-2-yl)-
132627-73-7
exfoliazone
n-[8-(hydroxymethyl)-3-oxophenoxazin-2-yl]acetamide
CHEMBL2311997
DTXSID10157675
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID722070Induction of nur77 gene expression in human NIH-H460 cells at 1 uM within 12 hrs by RT-PCR analysis2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID728966Inhibition of human recombinant N-terminus 6X-histidine-tagged indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as inhibition of L-tryptophan to N-formylkynurenine formation measured as residual enzyme activity at 0.1 uM incubated for 152013Journal of medicinal chemistry, Apr-25, Volume: 56, Issue:8
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.
AID722073Cytotoxicity against human Bel7042 cells by MTT method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID722075Cytotoxicity against human A2780 cells by MTT method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID728968Inhibition of human recombinant N-terminus 6X-histidine-tagged indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as inhibition of L-tryptophan to N-formylkynurenine formation measured as residual enzyme activity at 10 uM incubated for 15 2013Journal of medicinal chemistry, Apr-25, Volume: 56, Issue:8
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.
AID722071Induction of nur77 gene expression in human NIH-H460 cells at 10 uM within 6 hrs by RT-PCR analysis2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID722077Cytotoxicity against human A549 cells by MTT method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID728967Inhibition of human recombinant N-terminus 6X-histidine-tagged indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as inhibition of L-tryptophan to N-formylkynurenine formation measured as residual enzyme activity at 1 uM incubated for 15 m2013Journal of medicinal chemistry, Apr-25, Volume: 56, Issue:8
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.
AID722068Induction of nur77 gene expression in human NIH-H460 cells after 6 to 12 hrs by RT-PCR analysis2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID722074Cytotoxicity against human NIH-H460 cells by MTT method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID722076Cytotoxicity against human BGC823 cells by MTT method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID722078Cytotoxicity against human HCT8 cells by MTT method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
AID722069Induction of nur77 gene expression in human NIH-H460 cells at 1 to 10 uM by RT-PCR analysis2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0810nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
2-aminophenol
[no description available]		2.0810aminophenolbacterial metabolite
4(5)-phenylimidazole
4(5)-phenylimidazole: tautomeric cpd; cytochrome P450 14alpha-sterol demethylase, CYP51 antagonist		2.0810
3-aminophenoxazone
3-aminophenoxazone: also inhibits sulfatase; structure		2.0810phenoxazine
cinnabarinic acid
cinnabarinic acid: structure		2.0810phenoxazine
ws 9659 a
lavanducyanin: isolated from Steptomyces sp. CL190& from Streptomyces sp No.9659		1.9810
heliomycin
heliomycin: Russian drug; antibiotic with antiviral properties isolated from Actinomyces flavochromogenes var. heliomycini; structure		2.2510
prodigiosin
Prodigiosin: 4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)- 2,2'-bi-1H-pyrrole. A toxic, bright red tripyrrole pigment from Serratia marcescens and others. It has antibacterial, anticoccidial, antimalarial, and antifungal activities, but is used mainly as a biochemical tool.. prodigiosin : A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.		2.2510
undecylprodigiosin
prodigiosin 25C: red pigment produced by Streptomyces hiroshimensis; potent immunosuppressive agent with its primary effect on functions of T cells; structure given in first source. undecylprodigiosin : A member of the class of tripyrroles that is 1H-pyrrole substituted by (4'-methoxy-1H,5'H-[2,2'-bipyrrol]-5'-ylidene)methyl and undecyl groups at positions 2 and 5, respectively. It is a pigment produced by Stveptomyces coelicolor.		2.2510alkaloid;
aromatic ether;
tripyrrole		antibacterial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite;
biological pigment;
immunosuppressive agent;
radiosensitizing agent
ConditionIndicatedRelationship StrengthStudiesTrials