Page last updated: 2024-12-07

disiloxane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID123318
CHEBI ID48141
MeSH IDM0165422

Synonyms (14)

Synonym
disiloxane
13597-73-4
CHEBI:48141
disiloxan
h3si-o-sih3
oxybis(silane)
silyloxysilane
bis-silyl ether
bis silyl ether
KPUWHANPEXNPJT-UHFFFAOYSA-N
mono-silyl ether
silylether
Q2675470
h3 si o si h3

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" X-ray crystallography validated the dimeric mechanism of inhibition, and 1a demonstrated good oral bioavailability and efficacy in HMC-1 xenograft models."( A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase.
Arnold, LD; Barany, F; Bergstrom, DE; Giardina, SF; Pingle, M; Werner, DS, 2018
)
0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
siloxaneSiloxanes are saturated silicon-oxygen hydrides with unbranched or branched chains of alternating silicon and oxygen atoms (each silicon atom is separated from its nearest silicon neighbours by single oxygen atoms). By extension hydrocarbyl derivatives are commonly included.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.55)18.7374
1990's1 (4.55)18.2507
2000's4 (18.18)29.6817
2010's10 (45.45)24.3611
2020's6 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.62 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index5.26 (4.65)
Search Engine Demand Index79.57 (26.88)
Search Engine Supply Index2.88 (0.95)

This Compound (40.62)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]