agosterol a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

agosterol A: from marine sponge Spongia sp. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10348156
CHEMBL ID	82446
MeSH ID	M0391747

Synonyms (13)

Synonym
agosterol a
CHEMBL82446
ytc6258tar ,
213549-32-7
cholest-7-ene-3,4,6,11,22-pentol, 3,4,6-triacetate, (3beta,4beta,5alpha,6alpha,11alpha,22r)-
unii-ytc6258tar
Q15410233
[(3s,4r,5s,6s,9r,10r,11r,13r,14r,17r)-4,6-diacetyloxy-11-hydroxy-17-[(2s,3r)-3-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] acetate
cholest-7-ene-3,4,6,11,22-pentol, 3,4,6-triacetate, (3beta,4beta,5alpha,6alpha,11alpha,22r)-
(1r,3ar,5s,5as,6r,7s,9ar,9br,10r,11ar)-6,7-bis(acetyloxy)-10-hydroxy-1-[(2s,3r)-3-hydroxy-6-methylheptan-2-yl]-9a,11a-dimethyl-1h,2h,3h,3ah,5h,5ah,6h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-5-yl acetate
cholest-7-ene-3,4,6,11,22-pentol, 3,4,6-triacetate, (3.beta.,4.beta.,5.alpha.,6.alpha.,11.alpha.,22r)-
DTXSID701045583
AKOS040750203

Research Excerpts

Overview

Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrugged resistance (MDR)

Excerpt	Reference	Relevance
"Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). "	( Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A. Akiyama, S; Aoki, S; Baba, M; Furukawa, T; Haraguchi, M; Kobayashi, M; Mitsuo, M; Nagata, Y; Nakajima, Y; Noguchi, T; Ren, XQ; Sumizawa, T, 2003)	1.99

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID95342	The compound was evaluated to Inhibit the growth of KB CV-60 cells at 3 ug/mL in the presence of vincristine (0.1 ug/ML)	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
AID94002	Cytotoxicity was evaluated against KB-3-1 cells at 10 ug/mL	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
AID94185	The compound was evaluated to Inhibit the growth of KB-C2 cells at 1 ug/mL n the presence of colchicine (0.1 ug/ML)	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
AID356408	Inhibition of chymotrypsin like activity of partially purified rat liver proteasome	2003	Journal of natural products, Sep, Volume: 66, Issue:9	New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp.
AID680575	TP_TRANSPORTER: inhibition of MTX uptake (MTX: 1 uM, AG-A: 1000 uM) in membrane vesicles from MRP3-expressing HEK293 cells	2001	Cancer research, Oct-01, Volume: 61, Issue:19	Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.
AID94187	The compound was evaluated to Inhibit the growth of KB-C2 cells at 3 ug/mL n the presence of colchicine (0.1 ug/ML)	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
AID95341	The compound was evaluated to Inhibit the growth of KB CV-60 cells at 10 ug/mL in the presence of vincristine (0.1 ug/ML)	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
AID94186	The compound was evaluated to Inhibit the growth of KB-C2 cells at 10 ug/mL in the presence of colchicine (0.1 ug/ML)	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
AID356410	Cytotoxicity against human HeLa cells after 3 days by MTT assay	2003	Journal of natural products, Sep, Volume: 66, Issue:9	New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp.
AID95340	The compound was evaluated to Inhibit the growth of KB CV-60 cells at 1 ug/mL in the presence of vincristine (0.1 ug/ML)	2000	Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22	Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.91 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	5.30 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.91)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2	1	aromatic ether; nitrile; polyether; tertiary amino compound
ono 1078 pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist	2	1	chromones
probenecid Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.	2	1	benzoic acids; sulfonamide	uricosuric drug
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.01	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
vincristine [no description available]	2.41	2	acetate ester; formamides; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	2.01	1	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.7	3	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.01	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
taurocholic acid Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.. taurocholate : An organosulfonate oxoanion that is the conjugate base of taurocholic acid.. taurocholic acid : A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.	2	1	amino sulfonic acid; bile acid taurine conjugate	human metabolite
glycocholic acid Glycocholic Acid: The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed.. glycocholic acid : A bile acid glycine conjugate having cholic acid as the bile acid component.. glycocholate : A cholanic acid conjugate anion that is the conjugate base of glycocholic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.	2	1	bile acid glycine conjugate	human metabolite
etoposide [no description available]	2.41	2	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
methotrexate [no description available]	2	1	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent
ergosterol [no description available]	2	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2	1	organic sodium salt	detergent; protein denaturant
leukotriene c4 Leukotriene C4: The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene C4 : A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.	2.01	1	leukotriene	bronchoconstrictor agent; human metabolite; mouse metabolite
sdz psc 833 valspodar: nonimmunosuppressive cyclosporin analog which is a potent multidrug resistance modifier; 7-10 fold more potent than cyclosporin A; a potent P glycoprotein inhibitor; MW 1215	2	1	homodetic cyclic peptide
estradiol-17 beta-glucuronide 17beta-estradiol 17-glucosiduronic acid : A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 17 via a glycosidic linkage.	2	1	3-hydroxy steroid; steroid glucosiduronic acid
l 660,711 [no description available]	2	1	quinolines
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	2	1	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
folic acid folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.	2	1	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient
leucovorin 5-formyltetrahydrofolic acid : A formyltetrahydrofolic acid in which the formyl group is located at position 5.	2	1	formyltetrahydrofolic acid	Escherichia coli metabolite; mouse metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Carcinoma, Epidermoid [description not available]	0	2.01	1	0
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	0	2.01	1	0

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