| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
choline
[no description available] | 2.02 | 1 | 0 | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite |
dimethylamine
[no description available] | 2.05 | 1 | 0 | methylamines;
secondary aliphatic amine | metabolite |
ethanolamine
[no description available] | 2.44 | 2 | 0 | ethanolamines;
primary alcohol;
primary amine | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
3-(1-methylpyrrolidin-2-yl)pyridine
3-(1-methylpyrrolidin-2-yl)pyridine : An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. | 2.05 | 1 | 0 | N-alkylpyrrolidine;
pyridine alkaloid;
pyrrolidine alkaloid | |
hydroxide ion
[no description available] | 2.1 | 1 | 0 | oxygen hydride | mouse metabolite |
trimethylamine
[no description available] | 2.05 | 1 | 0 | methylamines;
tertiary amine | Escherichia coli metabolite;
human xenobiotic metabolite |
4-aminopyridine
[no description available] | 2.05 | 1 | 0 | aminopyridine;
aromatic amine | avicide;
orphan drug;
potassium channel blocker |
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. | 1.98 | 1 | 0 | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug |
tetraethylammonium
Tetraethylammonium: A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90) | 2.05 | 1 | 0 | quaternary ammonium ion | |
trifluperidol
Trifluperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621) | 1.98 | 1 | 0 | aromatic ketone | |
amifampridine
Amifampridine: 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES. | 2.05 | 1 | 0 | aminopyridine | |
choline chloride
choline chloride : A quaternary ammonium salt with choline cation and chloride anion. | 2.05 | 1 | 0 | chloride salt;
quaternary ammonium salt | animal growth promotant |
methylamine
methyl group : An alkyl group that is the univalent group derived from methane by removal of a hydrogen atom. | 2.05 | 1 | 0 | methylamines;
one-carbon compound;
primary aliphatic amine | mouse metabolite |
tetramethylammonium chloride
[no description available] | 2.05 | 1 | 0 | organic molecular entity | |
quinoline
[no description available] | 1.98 | 1 | 0 | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinolines | |
quinuclidines
Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group. | 3.67 | 9 | 0 | quinuclidines;
saturated organic heterobicyclic parent | |
deanol
Deanol: An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.. N,N-dimethylethanolamine : A tertiary amine that is ethanolamine having two N-methyl substituents. | 2.44 | 2 | 0 | ethanolamines;
tertiary amine | curing agent;
radical scavenger |
gamma-collidine
gamma-collidine: structure | 2.05 | 1 | 0 | methylpyridines | |
n-methylaminoethanol
N-methylaminoethanol: structure. N-methylethanolamine : An ethanolamine compound having an N-methyl substituent. | 2.44 | 2 | 0 | ethanolamines | |
yohimbine
Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.. yohimbine : An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina. | 1.98 | 1 | 0 | methyl 17-hydroxy-20xi-yohimban-16-carboxylate | alpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist |
methoxytryptophol
[no description available] | 1.98 | 1 | 0 | indoles | |
1-methylpyridinium
1-methylpyridinium: RN given refers to parent cpd | 2.02 | 1 | 0 | methylpyridines | |
5-methoxyindole
5-methoxyindole: structure in first source | 1.98 | 1 | 0 | indoles | |
6-methoxyquinoline
6-methoxyquinoline: RN given refers to parent cpd. 6-methoxyquinoline : An aromatic ether that is quinoline substituted at position 6 by a methoxy group. | 1.98 | 1 | 0 | aromatic ether;
quinolines | |
beta-methylcholine
beta-methylcholine: RN given refers to non-isomeric parent cpd; see also record for methylcholine; do not confuse with alpha-methylcholine | 2.02 | 1 | 0 | cholines | |
3-quinuclidinone
[no description available] | 7.96 | 4 | 0 | | |
homocholine
homocholine: record includes halides; iodide used as internal standard for paired-ion HPLC assay for choline; RN given refers to parent cpd | 2.02 | 1 | 0 | | |
dimethyldodecylbenzylammonium
benzododecinium bromide : The organic bromide salt of benzododecinium. It is a cationic surfactant that has antispetic and disinfectant properties. | 2.21 | 1 | 0 | organic bromide salt;
quaternary ammonium salt | antiseptic drug;
disinfectant;
surfactant |
monoethylcholine
monoethylcholine: competitively inhibits transport of choline; RN given refers to parent cpd | 2.02 | 1 | 0 | | |
cetylpyridinium chloride anhydrous
tserigel: according to first source contains polyvinylbutyral & cetylpyridinium chloride; UD only lists cetylpyridinium chloride as constituent. cetylpyridinium chloride : A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat. | 2.05 | 1 | 0 | chloride salt;
organic chloride salt | antiseptic drug;
surfactant |
trimethylethylammonium
trimethylethylammonium: RN given refers to parent cpd. ethyltrimethylammonium : A quarternary ammonium cation having one ethyl and three methyl substituents around the central nitrogen. | 2.02 | 1 | 0 | quaternary ammonium ion | |
prodipin
[no description available] | 1.98 | 1 | 0 | | |
harmol
harmol: harmol is oxidized form of alkaloid harmolol; RN given refers to parent cpd; structure | 1.98 | 1 | 0 | harmala alkaloid | |
4-tolyl isocyanate
4-tolyl isocyanate : An isocyanate comprising a benzene core with isocyanato and methyl substituents para to each other. | 2.1 | 1 | 0 | isocyanates;
toluenes | allergen;
hapten |
tetrabutylammonium chloride
tetra-n-butylammonium chloride: structure in first source. tetrabutylammonium chloride : An organic chloride salt comprising of a tetrabutylammonium cation and chloride anion. | 2.05 | 1 | 0 | organic chloride salt;
tetrabutylammonium salt | |
tetrahydroalstonine
tetrahydroalstonine : A heteropentacyclic compound that is (20alpha)-16,17-didehydro-18-oxayohimban which is substituted at position 16 by a methoxycarbonyl group and at position 19 by a methyl group. It is a metabolite found in several plant species. | 1.98 | 1 | 0 | methyl ester;
organic heteropentacyclic compound;
yohimban alkaloid | plant metabolite |
dimethylaminopropanol
dimethylaminopropanol: dimethylamine precursor | 2.05 | 1 | 0 | | |
methylthioethanol
2-methylthioethanol : A primary alcohol that is the S-methyl derivative of mercaptoethanol. It is found as a volatile component in Cucumis melo Var. cantalupensis. | 2.02 | 1 | 0 | aliphatic sulfide;
primary alcohol | plant metabolite;
xenobiotic metabolite |
corynanthine
Corynanthine: A stereoisomer of yohimbine. | 1.98 | 1 | 0 | yohimban alkaloid | |
cyanates
Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N). | 2.1 | 1 | 0 | | |
quinidine
Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | 1.98 | 1 | 0 | cinchona alkaloid | alpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker |
raubasine
ajmalicine : A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. | 1.98 | 1 | 0 | methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound | alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent |
lobeline
[no description available] | 1.98 | 1 | 0 | | |
quinine
[no description available] | 1.98 | 1 | 0 | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic |
harmine
Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.. harmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7. | 1.98 | 1 | 0 | harmala alkaloid | anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite |
harman
harman: a beta-carboline; RN given refers to parent cpd; structure. harman : An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A. | 1.98 | 1 | 0 | harmala alkaloid;
indole alkaloid fundamental parent;
indole alkaloid | anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite |
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety. | 2.08 | 1 | 0 | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite |