2-methyladenine is a naturally occurring purine derivative found in various biological systems. It is often found as a component of tRNA, where it plays a role in the recognition of specific codons during protein synthesis. Research on 2-methyladenine focuses on its biological significance, its role in gene expression, and its potential therapeutic applications. Notable applications include its use as a biomarker for certain cancers and its potential to modulate immune responses. Its synthesis can be achieved via various methods, including chemical modification of adenine or through enzymatic reactions. 2-methyladenine has also been shown to exhibit antiviral activity against certain viruses, further highlighting its biological and therapeutic potential.'
methyladenine : Any member of the class of 6-aminopurines that is adenine bearing a single methyl substituent. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 15048 |
| CHEMBL ID | 330897 |
| SCHEMBL ID | 19779 |
| MeSH ID | M0138134 |
| Synonym |
|---|
| nsc 26364 |
| 2-methyl-1h-purin-6-amine , |
| 2-methyl-9h-purin-6-ylamine |
| bdbm50030961 |
| (2-methyl-9h-purin-6-yl)-amine |
| nsc-26364 |
| nsc26364 |
| sq 23354 |
| 1h-purin-6-amine, 2-methyl- |
| adenine, 2-methyl- |
| sq 23,354 |
| 2-methyl-6-aminopurine |
| 2-methyl-9h-purin-6-amine |
| 1445-08-5 |
| 2-methyladenine |
| 2-methyl-7h-purin-6-amine |
| CHEMBL330897 , |
| A808223 |
| 2-methyl-7h-purin-6-amine;2-methyl-1h-purin-6-amine |
| AKOS006338122 |
| AKOS015905348 |
| SCHEMBL19779 |
| 2-methyladenin |
| SMADWRYCYBUIKH-UHFFFAOYSA-N |
| methyladenine |
| 1h-purin-6-amine, 2-methyl- (9ci) |
| AKOS024463815 |
| DTXSID80162731 |
| mfcd01674065 |
| methyl-3h-adenine |
| DS-8040 |
| 1h-purin-6-amine,2-methyl- |
| Q15632702 |
| 1h-purin-6-amine pound not 2-methyl- (9ci) |
| BCP29033 |
| 9h-purin-6-amine, 2-methyl- |
| D84317 |
| BAA44508 |
| CS-0186661 |
| J5S7AW6A3C |
| sq-23354 |
| Pathway | Proteins | Compounds |
|---|---|---|
| 2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP | 3 | 8 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 (µMol) | 8,000.0000 | 6.0000 | 7.3333 | 8.0000 | AID75706; AID75716; AID75728 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 (µMol) | 320.0000 | 0.0004 | 1.3452 | 10.0000 | AID51554 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.53) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||