Page last updated: 2024-12-07

5,6-methylenedioxy-2-aminoindane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5,6-methylenedioxy-2-aminoindane: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125558
CHEMBL ID162375
CHEBI ID189818
SCHEMBL ID5318502
MeSH IDM0182949

Synonyms (29)

Synonym
AC-3402
mdai
6,7-dihydro-5h-cyclopenta[f][1,3]benzodioxol-6-amine
5,6-methylenedioxy-2-aminoindan
bdbm50010589
6,7-dihydro-5h-indeno[5,6-d][1,3]dioxol-6-ylamine
CHEMBL162375 ,
132741-81-2
CHEBI:189818
6,7-dihydro-5h-cyclopenta[][1,3]benzodioxol-6-amine
A806492
AKOS005762887
6,7-dihydro-5h-indeno(5,6-d)-1,3-dioxol-6-amine
5,6-methylenedioxy-2-aminoindane
5h-indeno(5,6-d)-1,3-dioxol-6-amine, 6,7-dihydro-
0dmj6g3xbf ,
unii-0dmj6g3xbf
6,7-dihydro-5h-cyclopenta(f)(1,3)benzodioxol-6-amine
SCHEMBL5318502
6,7-dihydro-5h-indeno[5,6-d][1,3]dioxol-6-amine
FQDRMHHCWZAXJM-UHFFFAOYSA-N
5h-indeno[5,6-d]-1,3-dioxol-6-amine, 6,7-dihydro-
DTXSID60157741
mdai; 5,6-methylenedioxy-2-aminoindane
5,6-methylenedioxy-2-aminoindane (mdai)
mdai (5,6-methylenedioxy-2-aminoindane) 1.0 mg/ml in acetonitrile
BCP06557
E10132
Q6715120

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Unexpectedly, 40mg/kg MDAI killed 90% of animals in the first behavioural test, hence LD50 tests were conducted which yielded 28."( Emerging toxicity of 5,6-methylenedioxy-2-aminoindane (MDAI): Pharmacokinetics, behaviour, thermoregulation and LD50 in rats.
Balíková, M; Čegan, M; Himl, M; Horsley, RR; Kuchař, M; Lhotková, E; Mikšátková, P; Páleníček, T; Tylš, F; Valeš, K; Žídková, M, 2016
)
0.75
" The present study showed strong cytotoxic potential for the NPS 5F-PB-22 and MDAI, moderate effects for MDMA, MDPV, methylone, cathinone, 4-MEC, and mephedrone, and no toxic effects for methamphetamine."( Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.
Beck, A; Flockerzi, V; Maurer, HH; Meyer, MR; Richter, LHJ, 2019
)
0.51

Dosage Studied

ExcerptRelevanceReference
" More importantly, if a subacute dosing regimen (every 12 hours for 4 days) was utilized, the combination of S-amphetamine with MDAI resulted in a marked long-term decrease in the levels of cortical, hippocampal and striatal 5-HT, 5-HIAA and the number of 5-HT uptake sites."( Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue.
Huang, XM; Johnson, MP; Nichols, DE, 1991
)
0.28
" Metabolism of MDAI, which has been hitherto unexplored, was studied in rats dosed with a subcutaneous dose of 20 mg MDAI."( Study on the metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites.
Balíková, M; Dušek, M; Himl, M; Lhotková, E; Linhart, I; Páleníček, T; Váňa, L; Vetýška, M; Židková, M, 2017
)
0.75
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzodioxoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID189911Tested for disruption in more than 50% rats trained to discriminate LSD from saline at a dose 9.36(uM/kg) (no. of animals =6)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175188Percentage of animals disrupted was determined in groups of LSD trained rats at a dose of 4.68(uM/kg) (no. of animals = 15)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190063Tested for stimulus generation in rats trained to discriminate +/-MDMA from saline at 2.34 (umol/kg), (number of animals = 10)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175192Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose 9.36 (uM/kg), (no.of animals=10)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175189Percentage of animals disrupted was determined in groups of LSD trained rats at a dose of 9.36(uM/kg) (no. of animals =6)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184520Monoamine levels in rat hippocampus were evaluated after subcutaneous administration of 40 mg/kg for 5-HIAA1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175197Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose 4.68 (uM/kg), (no.of animals=8)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184521Monoamine levels in rat hippocampus were evaluated after subcutaneous administration of 40 mg/kg for 5-HT1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190092Tested for stimulus generation in rats trained to discriminate LSD from saline at a dose 1.17 (umol/kg) (number of animals =16)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190070Tested for stimulus generation in rats trained to discriminate +/-MDMA from saline at 4.68 (umol/kg), (number of animals = 8)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184514Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for 5-HIAA1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184515Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for 5-HT1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184516Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for DA1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID174867Hallucinogenic property was determined in groups of LSD trained rats and percentage of animals disrupted was reported at a dose 0.59(uM/kg), (number of animals = 11)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184518Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for HVA1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID189916Tested for stimulus generation in rats trained to discriminate +/-MDMA from saline at 1.17 (umol/kg), (number of animals = 8)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184513Monoamine levels in at hippocampus were evaluated after subcutaneous administration of 40 mg/kg for NE1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190096Tested for stimulus generation in rats trained to discriminate LSD from saline at a dose 2.34 (umol/kg) (number of animals = 10)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175044Percentage of animals disrupted was determined in groups of LSD trained rats at a dose of 2.34(uM/kg) (no. of animals = 10)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175042Percentage of animals disrupted was determined in groups of LSD trained rats at a dose of 1.17(uM/kg)(no. of animals =16)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190090Tested for stimulus generation in rats trained to discriminate LSD from saline at a dose 0.59(uM/kg), (number of animals = 11)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID88605Bmax for compound was evaluated in rat hippocampal homogenate1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID205028Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat brain cortical homogenate1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID205029Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat hippocampal homogenate1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184517Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for DOPAC1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175014Hallucinogenic property was determined in groups of MDMA trained rats and percentage of animals disrupted was reported at a dose 1.17 (umol/kg), (number of animals = 8)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID176238Inhibitory activity was determined MDMA trained rats1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190247Tested for stimulus generation in rats trained to discriminate LSD from saline at a dose 4.68 (umol/kg),(number of animals = 15)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID190077Tested for stimulus generation in rats trained to discriminate +/-MDMA from saline at 9.36 (umol/kg), (number of animals = 10)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID184519Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for NE1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID175191Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose 2.34 (uM/kg), (no.of animals=10)1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
AID51040Bmax for compound was evaluated in rat cortical homogenate1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (25.00)18.2507
2000's0 (0.00)29.6817
2010's12 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.73 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (23.53%)6.00%
Case Studies3 (17.65%)4.05%
Observational0 (0.00%)0.25%
Other10 (58.82%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]