5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
Definition
Target type: molecularfunction
Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai]
5-Hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid (5-HETE) is a bioactive lipid produced from the metabolism of arachidonic acid by 5-lipoxygenase. Its molecular function is primarily related to its ability to bind to and activate various cellular receptors, leading to downstream signaling pathways. 5-HETE is a potent chemoattractant for neutrophils and other leukocytes, playing a role in inflammatory responses. It binds to the G protein-coupled receptor, formyl peptide receptor 2 (FPR2), triggering intracellular signaling cascades that lead to cell migration and activation. Additionally, 5-HETE interacts with other receptors, including the leukotriene B4 receptor (BLT1) and the peroxisome proliferator-activated receptor alpha (PPARα), modulating diverse cellular processes such as cell proliferation, apoptosis, and immune regulation. Furthermore, 5-HETE has been implicated in various pathological conditions, including inflammation, cancer, and cardiovascular disease, where its binding to specific receptors contributes to disease progression. '
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Oxoeicosanoid receptor 1 | An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| docosahexaenoate | all-cis-docosa-4,7,10,13,16,19-hexaenoic acid : A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. docosahexaenoate : A polyunsaturated fatty acid anion that is the conjugate base of docosahexaenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3. docosahexaenoic acid : Any C22 polyunsaturated fatty acid containing six double bonds. efalex: a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement | docosahexaenoic acid; omega-3 fatty acid | algal metabolite; antineoplastic agent; Daphnia tenebrosa metabolite; human metabolite; mouse metabolite; nutraceutical |
| eicosapentaenoic acid | all-cis-5,8,11,14,17-icosapentaenoic acid : An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17. icosapentaenoic acid : Any straight-chain, C20 polyunsaturated fatty acid having five C=C double bonds. | icosapentaenoic acid; omega-3 fatty acid | anticholesteremic drug; antidepressant; antineoplastic agent; Daphnia galeata metabolite; fungal metabolite; micronutrient; mouse metabolite; nutraceutical |
| 8,11,14-eicosatrienoic acid | 8,11,14-Eicosatrienoic Acid: A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. all-cis-icosa-8,11,14-trienoic acid : An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14. | fatty acid 20:3; long-chain fatty acid | fungal metabolite; human metabolite; nutraceutical |
| 12-hydroxy-5,8,10,14-eicosatetraenoic acid | 12-HETE : A HETE that is icosa-5,8,10,14-tetraenoic acid substituted by a hydroxy group at position 12. It is a metabolite of arachidonic acid. 12(S)-HETE : A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds. | (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid; HETE | human metabolite; pro-angiogenic agent |
| 5-oxo-6,8,11,14-eicosatetraenoic acid | 5-ketoeicosatetraenoic acid: a nonenzymatic rearrangement product of leukotriene A4; structure given in first source 5-oxo-ETE : An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds. | oxoicosatetraenoic acid | human metabolite; immunomodulator; mouse metabolite |
| 11,14,17-eicosatrienoate | all-cis-icosa-11,14,17-trienoic acid : An icosatrienoic acid having three cis- double bonds at positions 11, 14 and 17. | fatty acid 20:3; omega-3 fatty acid | |
| 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid | (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid : An icosanoid that is (6E,8Z,11Z,13E)-icosatetraenoic acid substituted at positions 5 and 15 by oxo and hydroxy groups respectively. 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid: a potent eosinophil chemotactic lipid formed by incubating human eosinophils with arachidonic acid | enone; hydroxy polyunsaturated fatty acid; icosanoid; long-chain fatty acid; oxo fatty acid; secondary allylic alcohol | human xenobiotic metabolite |