5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding

Definition

Target type: molecularfunction

Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai]

5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid (5-HPETE) is a bioactive lipid mediator involved in various cellular processes, including inflammation, immunity, and cell signaling. Its binding to specific target proteins mediates these diverse functions. The molecular function of 5-HPETE binding can be described in detail as follows:

1. **Activation of Lipid Peroxidases:** 5-HPETE serves as a substrate for lipoxygenases, a class of enzymes involved in the metabolism of polyunsaturated fatty acids. Specifically, 5-HPETE is a substrate for 12/15-lipoxygenases, which further metabolize it to generate other bioactive lipid mediators like 12(S)-HETE and 15(S)-HETE. These metabolites contribute to inflammatory responses and cell signaling.
2. **Modulation of Receptor Activity:** 5-HPETE has been shown to bind to and activate G protein-coupled receptors (GPCRs), such as the formyl peptide receptor (FPR). Activation of these receptors triggers downstream signaling pathways, leading to cellular responses like chemotaxis, degranulation, and cytokine production.
3. **Regulation of Gene Expression:** 5-HPETE can directly interact with transcription factors, such as nuclear factor-kappa B (NF-κB), influencing gene expression patterns. NF-κB is a key regulator of inflammation and immune responses, and 5-HPETE's modulation of its activity can impact the expression of inflammatory genes.
4. **Induction of Apoptosis:** In certain contexts, 5-HPETE has been shown to induce apoptosis, or programmed cell death. This apoptotic effect may contribute to the resolution of inflammation and the elimination of damaged cells.
5. **Interactions with Other Biomolecules:** 5-HPETE can also interact with other biomolecules, such as proteins and lipids, to modulate their activity. These interactions contribute to its pleiotropic effects in cellular processes.'
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Proteins (1)

Compounds (7)