5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding

Definition

Target type: molecularfunction

Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. [GOC:ai]

5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid (5-oxo-ETE) is a potent lipid mediator that binds to the G protein-coupled receptor, OXE receptor (OXER1), also known as the 5-oxo-ETE receptor. Upon binding, 5-oxo-ETE activates a signaling cascade involving G proteins, phospholipase C, and intracellular calcium mobilization. This leads to a variety of cellular responses, including:

* **Immune cell activation:** 5-oxo-ETE stimulates the migration and activation of neutrophils, eosinophils, and macrophages, contributing to inflammation and immune responses.
* **Bronchoconstriction:** 5-oxo-ETE induces bronchoconstriction in the airways, potentially playing a role in asthma and other respiratory diseases.
* **Smooth muscle contraction:** 5-oxo-ETE can trigger contraction in smooth muscle cells, including those found in the gastrointestinal tract and blood vessels.
* **Pain perception:** 5-oxo-ETE has been implicated in the development of pain, potentially by sensitizing peripheral nerve endings.
* **Other cellular processes:** 5-oxo-ETE has also been shown to influence cell proliferation, differentiation, and apoptosis, although the specific mechanisms are not fully understood.

In summary, 5-oxo-ETE binding to OXER1 initiates a signaling pathway that regulates a diverse range of cellular responses, primarily related to inflammation, immune function, and smooth muscle contraction.'
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Proteins (1)

Compounds (7)