Page last updated: 2024-12-08
n-(phenylsulfonyl)glycine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 220662 |
| CHEMBL ID | 37054 |
| SCHEMBL ID | 359770 |
| MeSH ID | M0292875 |
Synonyms (42)
| Synonym |
|---|
| EU-0083911 |
| HMS1490F06 |
| nsc121986 |
| nsc-121986 |
| 5398-96-9 |
| nsc-3682 |
| nsc3682 |
| CHEMDIV3_006100 |
| CBDIVE_002981 |
| OPREA1_645532 |
| OPREA1_227014 |
| CBCHROMO1_000178 |
| benzenesulfonylamino-acetic acid |
| IDI1_024010 |
| CHEMBL37054 , |
| 2-(phenylsulfonamido)acetic acid |
| AKOS000264084 |
| BRD-K91605397-001-01-0 |
| n-(phenylsulfonyl)glycine |
| bdbm50016561 |
| 2-(benzenesulfonamido)acetic acid |
| 2-benzenesulfonamidoacetic acid |
| EN300-06046 |
| CCG-117199 |
| STL477593 |
| AB01314976-02 |
| WTSZSAHZIMPSDM-UHFFFAOYSA-N |
| n-benzenesulfonyl-glycine |
| SCHEMBL359770 |
| [(phenylsulfonyl)amino]acetic acid, aldrichcpr |
| (phenylsulfonyl)glycine |
| n-benzenesulfonylglycine |
| [(phenylsulfonyl)amino]acetic acid |
| NCGC00320593-01 |
| mfcd00233404 |
| noname_454 |
| DTXSID90901350 |
| A870579 |
| glycine, n-(phenylsulfonyl)-; n-(phenylsulfonyl)glycine |
| CS-0453500 |
| PD180071 |
| Z45658533 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 132.0000 | 0.0004 | 1.8773 | 10.0000 | AID34970; AID381848 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID537157 | Inhibition of Fischer-344 rat lens ALR2 by least-square analysis | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID381848 | Inhibition of aldose reductase in rat lenses | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. |
| AID34970 | Inhibitory concentration against aldose reductase obtained from rat lens | 1989 | Journal of medicinal chemistry, Jan, Volume: 32, Issue:1 | N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase. |
| AID537155 | Inhibition of Fischer-344 rat kidney AK1A1 at 100 uM | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID537153 | Inhibition of rat lens ALR2 | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID537160 | Selectivity ratio of inhibition of Fischer-344 rat lens ALR2sto inhibition of Fischer-344 rat kidney AK1A1 at 100 uM | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID537156 | Inhibition of Fischer-344 rat lens ALR2 at 100 uM | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.51
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.51) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||