Page last updated: 2024-11-07

triptotriterpenic acid a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

triptotriterpenic acid A: from Tripterygium wilfordii; RN given refers to (3beta,22alpha)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

triptotriterpenic acid A : A pentacyclic triterpenoid with formula C30H48O4, originally isolated from Tripterygium hypoglaucum. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
TripterygiumgenusA plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.[MeSH]CelastraceaeA plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID21594203
CHEMBL ID458310
CHEBI ID132370
MeSH IDM0144788

Synonyms (13)

Synonym
maytenfolic acid
CHEBI:132370
(3beta,22alpha)-3,22-dihydroxyolean-12-en-29-oic acid
3beta,22alpha-dihydroxyolean-12-en-29-oic acid
bdbm50242240
triptotriterpenic acid a
CHEMBL458310 ,
84108-17-8
AKOS032962355
HY-N1118
CS-0016406
(2s,4s,4ar,6ar,6as,6br,8ar,10s,12ar,14bs)-4,10-dihydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2-carboxylic acid
DTXSID301316671
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
pentacyclic triterpenoid
hydroxy monocarboxylic acidAny monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent.
diolA compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC50 (µMol)72.00000.00041.877310.0000AID356411
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID355753Cytotoxicity against human COLO205 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus.
AID333599Induction of TNFalpha production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333600Induction of TNFalpha production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID355751Cytotoxicity against human KB cells2003Journal of natural products, Apr, Volume: 66, Issue:4
A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus.
AID333597Induction of IL12 production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333596Induction of IL6 production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID356411Inhibition of aldose reductase in rat lens homogenate2003Journal of natural products, Sep, Volume: 66, Issue:9
Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis.
AID333595Induction of IL6 production in human PBMC at 1 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
AID333598Induction of IL12 production in human PBMC at 10 ug/ml after 48 hrs by ELISA2004Journal of natural products, Nov, Volume: 67, Issue:11
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]