Page last updated: 2024-12-07

2-naphthoylglycine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-naphthoylglycine: RN not in Chemline 8/18/82 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID129671
CHEMBL ID8798
SCHEMBL ID5632427
MeSH IDM0108289

Synonyms (24)

Synonym
2-naphthuric acid
2-naphthoylglycine
AKOS000264527
CHEMBL8798 ,
69826-63-7
HMS1729L03
bdbm50009982
[(naphthalene-2-carbonyl)-amino]-acetic acid
2-(naphthalene-2-carbonylamino)acetic acid
(2-naphthoylamino)acetic acid
2-[(naphthalen-2-yl)formamido]acetic acid
EN300-08095
glycine, n-(2-naphthalenylcarbonyl)-
glycine,n-(2-naphthalenylcarbonyl)-
2-(naphthalen-2-ylformamido)acetic acid
DTXSID90220114
SCHEMBL5632427
sr-01000044843
SR-01000044843-1
(2-naphthoylamino)acetic acid #
Z56928566
[(naphthalene-2-carbonyl)amino]acetic acid
2-(2-naphthamido)acetic acid
2-(2-naphthamido)aceticacid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC50 (µMol)55.00000.00041.877310.0000AID34944; AID34965
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID34944Inhibition of aldose reductase from rat lens. Value ranges from 25-641989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety.
AID35127Inhibition of partially purified aldose reductase obtained from rat lens (100 uM ); ND is No Data1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety.
AID34965Inhibitory activity against aldose reductase in rat lens1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
Relative structure-inhibition analyses of the N-benzoyl and N-(phenylsulfonyl) amino acid aldose reductase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]