tingenin B: isolated from Glyptopetalum sclerocarpaum; structure given in first source; RN given refers to (20beta,22beta)-isomer; RN for cpd without isomeric designation not available 11/90; RN is for tingenin A (8/2001) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Glyptopetalum | genus | A plant genus of the family Celastraceae that contains glyptopetolide (ursane-type triterpene), sclerocarpic acid, (sesquiterpene), hydroxytingenone, isoarborinol and cangoronine (triterpenoids).[MeSH] | Celastraceae | A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 73147 |
| SCHEMBL ID | 20957640 |
| MeSH ID | M0181694 |
| Synonym |
|---|
| 22-hydroxytingenone |
| 50656-68-3 |
| (6as,6bs,8ar,9s,11r,12as,14ar)-3,9-dihydroxy-4,6a,6b,8a,11,14a-hexamethyl-7,8,9,11,12,12a,13,14-octahydropicene-2,10-dione |
| 24,25,26,30-tetranoroleana-1(10),3,5,7-tetraene-2,21-dione,3,22-dihydroxy-9,13-dimethyl-,(9.beta.,13.alpha.,14.beta,20.beta.,22.beta.)- |
| tingenin b |
| d:a-friedo-24,30-dinoroleana-1(10),3,5,7-tetraene-2,21-dione, 3,22-dihydroxy-, (20beta,22beta)- |
| 24,25,26,30-tetranoroleana-1(10),3,5,7-tetraene-2,21-dione,3,22-dihydroxy-9,13-dimethyl-, (9b,13a,14b,20b,22b)- |
| SCHEMBL20957640 |
| DTXSID80964893 |
| 3,9-dihydroxy-4,6b,8a,11,12b,14a-hexamethyl-7,8,8a,11,12,12a,12b,13,14,14a-decahydropicene-2,10(6bh,9h)-dione |
| AKOS040746410 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 7.0000 | 0.0004 | 1.8773 | 10.0000 | AID356411 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID356411 | Inhibition of aldose reductase in rat lens homogenate | 2003 | Journal of natural products, Sep, Volume: 66, Issue:9 | Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. |
| AID313986 | Inhibition of tubulin polymerization | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Antimitotic quinoid triterpenes from Maytenus chuchuhuasca. |
| AID566859 | Cytotoxicity against human MCF7 cells at 30 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID359903 | Cytotoxicity against mouse P388 cells by MTT assay | 1994 | Journal of natural products, Dec, Volume: 57, Issue:12 | Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca. |
| AID566857 | Cytotoxicity against human MCF7 cells at 1 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID566854 | Cytotoxicity against human HL60 cells at 1 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID566779 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID566855 | Cytotoxicity against human HL60 cells at 10 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID566858 | Cytotoxicity against human MCF7 cells at 10 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID566853 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| AID397122 | Inhibition of HIV1 RT | |||
| AID313987 | Growth inhibition of human RPMI8226 cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Antimitotic quinoid triterpenes from Maytenus chuchuhuasca. |
| AID566856 | Cytotoxicity against human HL60 cells at 30 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Dec-27, Volume: 73, Issue:12 | Cytotoxic triterpenoids from Maytenus retusa. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.40) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||