vialinin-a and Leukemia

vialinin-a has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for vialinin-a and Leukemia

Article	Year
Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes. Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7 Vialinin A (1) is an extremely potent inhibitor against tumor necrosis factor (TNF)-α production in rat basophilic leukemia (RBL-2H3) cells. This Letter describes the design and synthesis of its advanced analog, 5',6'-dimethyl-1,1':4'1″-terphenyl-2',3',4,4″-tetraol (2) with a comparable inhibitory activity (IC(50)=0.02 nM) to that of 1. The synthesis involved double Suzuki-Miyaura coupling as a key step, and required only five steps from commercially available 3,4-dimethylphenol. For identification of the target molecule, fluorescent and biotinylated derivatives of 2 were prepared through a 'click' coupling process. Topics: Animals; Biotinylation; Cell Line, Tumor; Drug Design; Fluorescence; Leukemia; Molecular Probes; Molecular Structure; Rats; Terphenyl Compounds; Tumor Necrosis Factor-alpha; Xylenes	2012

Article

Year

Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes.

Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7

Vialinin A (1) is an extremely potent inhibitor against tumor necrosis factor (TNF)-α production in rat basophilic leukemia (RBL-2H3) cells. This Letter describes the design and synthesis of its advanced analog, 5',6'-dimethyl-1,1':4'1″-terphenyl-2',3',4,4″-tetraol (2) with a comparable inhibitory activity (IC(50)=0.02 nM) to that of 1. The synthesis involved double Suzuki-Miyaura coupling as a key step, and required only five steps from commercially available 3,4-dimethylphenol. For identification of the target molecule, fluorescent and biotinylated derivatives of 2 were prepared through a 'click' coupling process.

Topics: Animals; Biotinylation; Cell Line, Tumor; Drug Design; Fluorescence; Leukemia; Molecular Probes; Molecular Structure; Rats; Terphenyl Compounds; Tumor Necrosis Factor-alpha; Xylenes

2012