Target type: molecularfunction
Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO. [GOC:mah]
SUMO-specific endopeptidase activity refers to the enzymatic cleavage of isopeptide bonds between SUMO (Small Ubiquitin-like Modifier) proteins and their target substrates. SUMOylation, a reversible post-translational modification, involves the attachment of SUMO to lysine residues of target proteins, affecting their function, localization, and interactions. SUMO-specific endopeptidases, also known as SENPs (Sentrin/SUMO-specific proteases), catalyze the removal of SUMO from SUMOylated proteins, thereby reversing the process of SUMOylation. This deSUMOylation is a crucial step in regulating the dynamic nature of SUMOylation and ensuring proper cellular function. SENPs exhibit substrate specificity, targeting different SUMO isoforms (SUMO1-4) and interacting with various SUMOylated proteins, contributing to the diversity and complexity of the SUMOylation pathway.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sentrin-specific protease 1 | A sentrin-specific protease 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0U3] | Homo sapiens (human) |
| Sentrin-specific protease 2 | A sentrin-specific protease 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC62] | Homo sapiens (human) |
| Sentrin-specific protease 1 | A sentrin-specific protease 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0U3] | Homo sapiens (human) |
| Sentrin-specific protease 2 | A sentrin-specific protease 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC62] | Homo sapiens (human) |
| Sentrin-specific protease 6 | A sentrin-specific protease 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZR1] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| streptonigrin | pyridines; quinolone | antimicrobial agent; antineoplastic agent | |
| ursolic acid | hydroxy monocarboxylic acid; pentacyclic triterpenoid | geroprotector; plant metabolite | |
| Tormentic acid | tormentic acid: aglycone of Rosamultin | triterpenoid | metabolite |
| atromentin | atromentin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione which is substituted by a 4-hydroxyphenyl group at positions 3 and 6. It is a mushroom pigment isolated from several fungi species and acts as a smooth muscle stimulant, and exhibits anticoagulant, antibacterial and antineoplastic properties. atromentin: an enoyl-ACP reductase (FabK) inhibitor; isolated from Streptococcus pneumoniae; structure in first source | dihydroxy-1,4-benzoquinones; polyphenol | antibacterial agent; anticoagulant; antineoplastic agent; apoptosis inducer; biological pigment; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; fungal metabolite |
| scoparianoside b | scoparianoside B: isolated from the fruit of Japanese Kochia scoparia; structure given in first source | triterpenoid saponin | |
| pomolic acid | pomolic acid: from Rosa woodsii & Hyptis capitata; structure in first source | triterpenoid | metabolite |
| vialinin a | vialinin A: free radical scavenger from an edible mushroom in China; structure in first source | ||
| gn6958 | GN6958: inhibits SUMO-sentrin specific protease 1 (SENP1); structure in first source |