dov-216303 and Disease-Models--Animal

dov-216303 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for dov-216303 and Disease-Models--Animal

Article	Year
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1 The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activity. The detailed synthesis and in vitro activity and ADME profile of compounds is described, which represent a previously undisclosed triple reuptake inhibitor chemotype. Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Mice; Naphthalenes; Neurotransmitter Uptake Inhibitors; Norepinephrine; Serotonin	2011

Article

Year

Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.

Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1

The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activity. The detailed synthesis and in vitro activity and ADME profile of compounds is described, which represent a previously undisclosed triple reuptake inhibitor chemotype.

Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Mice; Naphthalenes; Neurotransmitter Uptake Inhibitors; Norepinephrine; Serotonin

2011