Page last updated: 2024-12-07

19-norandrosterone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

19-norandrosterone is a synthetic steroid hormone. It is a derivative of testosterone, but it lacks the carbon atom at position 19, which gives it a distinct chemical structure.

Here's why it's important for research:

**1. Potential Therapeutic Uses:**

* **Muscle Growth and Strength:** 19-norandrosterone has been studied for its potential to stimulate muscle growth and increase strength, similar to other anabolic steroids. However, its use in this context is controversial due to potential side effects.
* **Hormone Replacement Therapy:** While not currently used clinically, 19-norandrosterone has been explored as a potential replacement for testosterone in men with hypogonadism (low testosterone levels).
* **Cognitive Function:** Research suggests 19-norandrosterone might have a role in improving cognitive function and memory, though more investigation is needed.

**2. Understanding Steroid Metabolism:**

* **Hormonal Pathway Studies:** 19-norandrosterone is a product of testosterone metabolism and serves as a marker for the activity of certain enzymes involved in steroid hormone production. Studying its levels can provide insights into the overall hormonal balance of the body.
* **Drug Development:** 19-norandrosterone is a valuable tool for understanding the mechanisms of action of other steroid hormones and for developing new drugs that target these pathways.

**3. Sports Doping:**

* **Performance Enhancement:** 19-norandrosterone has been abused by athletes for its potential to enhance performance. This has led to its inclusion on the World Anti-Doping Agency (WADA) prohibited list.

**4. Research Tool:**

* **Cell Culture Studies:** 19-norandrosterone is used in laboratory settings to study the effects of steroid hormones on various cell types.
* **Animal Models:** It's used in animal studies to investigate the role of steroids in different physiological processes.

**Important Considerations:**

* **Safety:** While 19-norandrosterone has potential therapeutic uses, it can also cause significant side effects, including liver damage, cardiovascular problems, and mood swings. It is not a safe or recommended substance for self-medication.
* **Ethical Considerations:** The use of 19-norandrosterone for performance enhancement raises ethical concerns and is strictly prohibited in most sporting organizations.

In conclusion, 19-norandrosterone is a synthetic steroid hormone with potential applications in research and medicine. However, its use is controversial due to safety concerns and ethical considerations related to its potential for abuse. Further research is needed to fully understand its therapeutic potential and minimize its risks.

19-norandrosterone: major metabolite of 19-nortestosterone; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9548753
CHEMBL ID3638321
CHEBI ID36412
SCHEMBL ID1220486
MeSH IDM0109984

Synonyms (30)

Synonym
19-norandrosterone
19-noreoiandrosterone
CHEBI:36412
3alpha-hydroxy-5alpha-estran-17-one
LMST02010042
1225-01-0
j109.668k ,
5W4XKU708V ,
SCHEMBL1220486
3-hydroxyestran-17-one #
UOUIARGWRPHDBX-CQZDKXCPSA-N
5.alpha.-estran-3.alpha.-ol-17-one
5.alpha.-estran-17-one, 3.alpha.-hydroxy-
estran-17-one, 3-hydroxy-, (3.alpha.,5.alpha.)-
CHEMBL3638321
estran-17-one, 3-hydroxy-, (3alpha,5alpha)-
5alpha-estran-3alpha-ol-17-one
5alpha-estran-17-one, 3alpha-hydroxy-
unii-5w4xku708v
5a-estran-3a-ol-17-one
(3a,5a)-3-hydroxy-estran-17-one
3a-hydroxy-5a-estran-17-one
h_14_19_norandrosterone
3alpha-hydroxy-5alpha-estran-17-one; 19-norandrosterone; 5alpha-estran-3alpha-ol-17-one
DTXSID10893662
(3r,5s,8r,9r,10s,13s,14s)-3-hydroxy-13-methyl-2,3,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-1h-cyclopenta[a]phenanthren-17-one
5alpha-19-norandrosterone
Q10859482
PD076329
(3as,3br,5as,7r,9as,9br,11as)-7-hydroxy-11a-methyl-hexadecahydro-1h-cyclopenta[a]phenanthren-1-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
17-oxo steroidAny oxo steroid carrying the oxo group at position 17.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (41)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (4.88)18.7374
1990's3 (7.32)18.2507
2000's25 (60.98)29.6817
2010's8 (19.51)24.3611
2020's3 (7.32)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (13.64%)5.53%
Reviews3 (6.82%)6.00%
Case Studies1 (2.27%)4.05%
Observational0 (0.00%)0.25%
Other34 (77.27%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]