19-norandrostenedione profile

19-norandrostenedione is a synthetic steroid hormone that is structurally similar to testosterone. It's important to understand that **19-norandrostenedione is not testosterone** and it does not directly convert to testosterone in the body.

Here's why it's important for research:

* **Potential therapeutic applications:** 19-norandrostenedione has been investigated for potential therapeutic applications in conditions like:
* **Muscle wasting:** Studies have explored its use in conditions like HIV/AIDS-related muscle wasting due to its potential to promote muscle growth.
* **Osteoporosis:** Research has explored its potential role in increasing bone mineral density and preventing bone loss.
* **Hormone replacement therapy:** Some studies have looked into its potential use in hormone replacement therapy, especially in women experiencing menopause.
* **Understanding steroid metabolism:** Studying 19-norandrostenedione helps researchers understand the complex pathways of steroid hormone metabolism in the body, including how different steroids are synthesized and metabolized.
* **Development of new drugs:** Research on 19-norandrostenedione has helped identify potential targets for drug development, particularly in the areas of muscle growth, bone health, and hormone regulation.

**However, it's crucial to note:**

* **Safety concerns:** 19-norandrostenedione has been linked to potential side effects, including liver damage, increased risk of blood clots, and masculinizing effects in women.
* **Limited clinical evidence:** While research has explored its potential, there is limited clinical evidence to support its safety and efficacy for any specific therapeutic application.
* **Regulation:** 19-norandrostenedione is often marketed as a dietary supplement, but its sale and use are regulated in many countries due to safety concerns.

**In summary:** 19-norandrostenedione is a synthetic steroid hormone that is being studied for potential therapeutic uses. However, its safety and efficacy are not fully established, and further research is needed before it can be widely used for medical purposes.

19-norandrostenedione: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	92834
CHEBI ID	34187
SCHEMBL ID	868884
MeSH ID	M0043593

Synonym
(+)-19-norandrost-4-ene-3,17-dione
estr-4-ene-3,17-dione
nsc12164
19-norandrostenedione
nsc-12164
.delta.4-estrene-3,17-dione
delta4-estrene-3,17-dione
delta,4-estrene-3,17-dione
DB01434
(8r,9s,10r,13s,14s)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione
19-norandrost-4-ene-3,17-dione
d-19-norandrost-4-ene-3,17-dione
3,17-dioxo-19-norandrost-4-ene
u90987pvu5 ,
nordione
(+)-estr-4-ene-3,17-dione
nsc 12164
einecs 211-995-8
unii-u90987pvu5
AKOS015896166
(+)-19-norandrost-4-en-3,17-dione
4-oestrendione
4-oestren-3,17-dione
4-norendione
norethisterone impurity b [ep impurity]
19-norandrost-4-en-3,17-dione
4-norendion
19-nor-4-androstene-3,17-dione
19-nor-4-androstene-3,17-dion
norethisterone acetate impurity j [ep impurity]
SCHEMBL868884
estra-4-ene-3,17-dione
estra4-ene-3,17-dione
CHEBI:34187
Q-102802
19-nor-androstene-4-ene-3,17-dione
19-norandrost-4-en-3,17-dione (8.beta.,9.alpha.,10.beta.)
norandrostenedione (19-norandrost-4-ene-3,17-dione)
norandrostenedione (19-norandrost-4-ene-3,17-dione) 1.0 mg/ml in acetonitrile
DTXSID50862392
Q4557695
estra-4-en-3,17-dione(19-nor ad)
(3as,3br,9ar,9bs,11as)-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthrene-1,7-dione
PD008864

Excerpt	Reference	Relevance
" This may be due to a slower rate of absorption and/or a reduced diuresis, resulting in a longer period for the metabolites to accumulate in the urine."	( Influence of delivery mode on the urinary excretion of nandrolone metabolites. Dunster, PM; Grace, PB; Houghton, E; Judkins, C; Maughan, RJ; Watson, P, 2010)	0.36

Excerpt	Relevance	Reference
" The dose-response of DHT was biphasic in the presence and absence of FSH, such that progesterone production in the presence of 8 micrograms/ml DHT was similar to basal progesterone production."	( Comparative effects of androgens and catecholestrogens on progesterone production by porcine granulosa cells. Hammond, JM; Spicer, LJ, 1988)	0.27

Class	Description
3-oxo steroid	Any oxo steroid where an oxo substituent is located at position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (26.83)	18.7374
1990's	7 (17.07)	18.2507
2000's	18 (43.90)	29.6817
2010's	4 (9.76)	24.3611
2020's	1 (2.44)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	8 (18.60%)	5.53%
Reviews	1 (2.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	34 (79.07%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
creatine [no description available]	2.05	1	0	glycine derivative; guanidines; zwitterion	geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	3.41	1	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
aminoglutethimide Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.. aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.	6.97	1	0	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
flutamide Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.	1.97	1	0	(trifluoromethyl)benzenes; monocarboxylic acid amide	androgen antagonist; antineoplastic agent
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	6.97	1	0	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
methyl methanesulfonate [no description available]	2.04	1	0	methanesulfonate ester	alkylating agent; apoptosis inducer; carcinogenic agent; genotoxin; mutagen
aldosterone [no description available]	1.95	1	0	11beta-hydroxy steroid; 18-oxo steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; mineralocorticoid; primary alpha-hydroxy ketone; steroid aldehyde	human metabolite; mouse metabolite
estrone Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.	2.89	4	0	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	7.38	2	0	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
testosterone propionate Testosterone Propionate: An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.. androgen : A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.	2.46	2	0	steroid ester
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	9.23	41	7	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
norethindrone Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for CONTRACEPTION.. norethisterone : A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.	2.05	1	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound; tertiary alcohol	progestin; synthetic oral contraceptive
maleic anhydride Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.	1.98	1	0	cyclic dicarboxylic anhydride; furans	allergen
pregnenolone [no description available]	2.21	1	0	20-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; C21-steroid	human metabolite; mouse metabolite
nandrolone Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.. nandrolone : A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.	11.44	16	3	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; anabolic androgenic steroid	human metabolite
androstenediol Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).. androst-5-ene-3beta,17beta-diol : A 3beta-hydroxy-Delta(5)-steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.	8.51	2	0	17beta-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid	androgen; human metabolite; mouse metabolite; radiation protective agent
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	1.97	1	0	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
formestane [no description available]	2.38	2	0	17-oxo steroid; 3-oxo-Delta(4) steroid; enol; hydroxy steroid	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
2,3-dimethylmaleic anhydride [no description available]	1.98	1	0	butenolide
boldenone boldenone: RN given refers to (17beta)-isomer. boldenone : An 3-oxo-Delta(1),Delta(4)-steroid substituted by an oxo group at position 3 and a beta-hydroxy group at position 17. It is an anabolic androgenic steroid that has been developed for veterinary use.	2.02	1	0	17beta-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; anabolic androgenic steroid
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.04	1	0	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
finasteride Finasteride: An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.. finasteride : An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.	3.42	1	1	3-oxo steroid; aza-steroid; delta-lactam	androgen antagonist; antihyperplasia drug; EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor
fadrozole Fadrozole: A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.	6.98	1	0	imidazopyridine
2-methoxyestradiol 2-methoxy-17beta-estradiol : A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.	1.97	1	0	17beta-hydroxy steroid; 3-hydroxy steroid	angiogenesis modulating agent; antimitotic; antineoplastic agent; human metabolite; metabolite; mouse metabolite
aminoglutethimide phosphate aminoglutethimide phosphate: inhibitor of steroidogenesis; RN given refers to phosphate in unspecified proportion to parent cpd	6.97	1	0
hydroxyflutamide [no description available]	1.97	1	0
19-oxo-delta(4) androstene-3,17-dione 19-oxo-delta(4) androstene-3,17-dione: RN given refers to unlabeled parent cpd; an estrogen prodrug. 3,17-dioxoandrost-4-en-19-al : An androstanoid that is androst-4-en-19-al substituted by oxo groups at positions 3 and 17.	1.97	1	0	17-oxo steroid; 19-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid; steroid aldehyde	human metabolite
estradiol 3-benzoate 17beta-estradiol 3-benzoate : A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.	2.04	1	0	17beta-hydroxy steroid; benzoate ester	estrogen receptor agonist; xenoestrogen
2-hydroxyestradiol 2-hydroxyestradiol: catechol estrogen; RN given refers to (17 beta)-isomer. 2-hydroxy-17beta-estradiol : A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2.	1.97	1	0	17beta-hydroxy steroid; 2-hydroxy steroid	carcinogenic agent; human metabolite; metabolite; mouse metabolite; prodrug
19-hydroxy-4-androstene-3,17-dione [no description available]	2.88	4	0	17-oxo steroid; 19-hydroxy steroid; 3-oxo steroid; androstanoid	mouse metabolite
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	1.96	1	0	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
nadp [no description available]	1.97	1	0
17-methylandrost-2-en-17-ol 17-methylandrost-2-en-17-ol: a designer steroid; structure in first source	2.46	2	0
19-norandrosterone 19-norandrosterone: major metabolite of 19-nortestosterone; RN given refers to cpd without isomeric designation	4.33	4	1	17-oxo steroid	metabolite
3,17-dihydroxy-5-estrene 3,17-dihydroxy-5-estrene: identified in urine samples from two male horses aged 8 & 14 years; structure given in first source	1.97	1	0

Condition	Relationship Strength	Studies
Chromosome-Defective Micronuclei [description not available]	2.04	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.05	1
Cancer of Prostate [description not available]	2.93	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.93	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.39	2
Breast Cancer [description not available]	1.97	1
Carcinoma, Anaplastic [description not available]	1.97	1
Breast Neoplasms Tumors or cancer of the human BREAST.	1.97	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1.97	1

19-norandrostenedione

Description

Cross-References

Synonyms (44)

Research Excerpts

Bioavailability

Dosage Studied

Drug Classes (1)

Research

Studies (41)

Market Indicators

Research Demand Index: 27.94

Study Types