Page last updated: 2024-11-12

3-nitrooxypropanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-nitrooxypropanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10011893
CHEMBL ID1817841
SCHEMBL ID220976
MeSH IDM000612136

Synonyms (27)

Synonym
3-hydroxypropyl nitrate
3-nop
3-nitrooxypropanol
CHEMBL1817841
abrucomstat
100502-66-7
1,3-propanediol, mononitrate
SCHEMBL220976
PTMLFFXFTRSBJW-UHFFFAOYSA-N
3-(nitrooxy)propan-1-ol
DTXSID10760800
3-nitroxypropanol
who 11507
unii-582n19cwp9
3-nitrooxypropan-1-ol
abrucomstat [usan]
582N19CWP9 ,
1,3-propanediol, 1-nitrate
abrucomstat [inn]
F83064
MS-22756
CS-0213543
HY-139566
mfcd31731012
SY345141
AKOS040756411
1,3-propanediole mononitrate

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Dosing 3 NP had a transitory inhibitory effect on methane production, which may have been due to the product leaving the rumen in liquid outflow or through absorption or metabolism."( Effects of 3-nitrooxypropanol on methane emission, digestion, and energy and nitrogen balance of lactating dairy cows.
Duval, S; Humphries, DJ; Kindermann, M; Kirton, P; Reynolds, CK; Steinberg, W, 2014
)
0.79
" 2, a greater dosage level of 3-NOP than 100 mg/kg (dietary DM) may need further examination of its effects on feeding behavior of beef cattle."( Effects of 3-nitrooxypropanol on enteric methane production, rumen fermentation, and feeding behavior in beef cattle fed a high-forage or high-grain diet1.
Beauchemin, KA; Campler, MR; Celi, P; Duval, SM; Hettick, JM; Kim, SH; Lee, C; Pairis-Garcia, MD; Pechtl, HA, 2019
)
0.9
"A dose-response experiment was designed to examine the effect of 3-nitrooxypropanol (3-NOP) on methane (CH4) emissions, rumen function and performance of feedlot cattle fed a tempered barley-based diet with canola oil."( Effect of 3-nitrooxypropanol on enteric methane emissions of feedlot cattle fed with a tempered barley-based diet with canola oil.
Almeida, AK; Cowley, F; Hegarty, RS; Karagiannis, A; McGrath, JJ; McMeniman, JP; Tamassia, LFM; Walker, N, 2023
)
1.55
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1357474Growth inhibition of human MCF7 cells after 24 hrs by MTT assay2018European journal of medicinal chemistry, May-10, Volume: 151Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
AID613505Vasodilatory activity at endothelium denuded Wistar rat thoracic aorta assessed as relaxation of phenylephrine-induced contraction2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
New nitric oxide or hydrogen sulfide releasing aspirins.
AID700918Vasodilatory activity in Wistar rat thoracic aorta assessed as inhibition of L-phenylephrine-induced contraction in presence of 1 uM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.
AID613503Vasodilatory activity at endothelium denuded Wistar rat thoracic aorta assessed as relaxation of phenylephrine-induced contraction preincubated for 30 mins before phenylephrine challenge in presence of 1 uM soluble guanylate cyclase inhibitor H-[1,2,4]Oxa2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
New nitric oxide or hydrogen sulfide releasing aspirins.
AID1357473Growth inhibition of human MDA-MB-231 cells after 24 hrs by MTT assay2018European journal of medicinal chemistry, May-10, Volume: 151Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
AID613137Antiaggregatory activity in plasma rich human platelets assessed as inhibition of collagen-induced platelet aggregation at 300 uM preincubated for 10 mins before collagen challenge measured 10 mins after stimulus addition2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
New nitric oxide or hydrogen sulfide releasing aspirins.
AID700917Vasodilatory activity in Wistar rat denuded thoracic aorta assessed as inhibition of L-phenylephrine-induced contraction2012Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.
AID1357472Growth inhibition of human HepG2 cells after 24 hrs by MTT assay2018European journal of medicinal chemistry, May-10, Volume: 151Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's17 (53.13)24.3611
2020's15 (46.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.58 (24.57)
Research Supply Index3.69 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index54.12 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (39.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials7 (21.88%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (78.13%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]