Target type: molecularfunction
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]
Oxidoreductases are enzymes that catalyze oxidation-reduction reactions. These enzymes transfer electrons from one molecule, called the donor, to another molecule, called the acceptor. In the specific case of oxidoreductases acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, these enzymes facilitate the transfer of electrons from an aldehyde or ketone molecule to either NAD+ or NADP+ as the electron acceptor. This process involves the oxidation of the aldehyde or ketone group, converting it to a carboxylic acid, while reducing NAD+ or NADP+ to NADH or NADPH. This type of oxidoreductase activity is essential in various metabolic pathways, including the breakdown of carbohydrates, the synthesis of fatty acids, and the detoxification of harmful substances. Some examples of enzymes belonging to this class include aldehyde dehydrogenases, which oxidize aldehydes to carboxylic acids, and ketone reductases, which reduce ketones to alcohols.'
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Protein | Definition | Taxonomy |
---|---|---|
All-trans-retinol dehydrogenase [NAD(+)] ADH4 | An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08319] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
tetramethylene sulfoxide | tetrahydrothiophenes | ||
isovaleramide | isovaleramide: inhibits liver alcohol dehydrogenases | ||
n-cyclohexylformamide | alicyclic compound; formamides | mouse metabolite | |
n-benzylformamide | formamides |