Target type: molecularfunction
Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. [EC:1.6.5.5]
NADPH:quinone reductase activity, also known as DT-diaphorase, is a crucial enzymatic activity that plays a pivotal role in cellular detoxification processes. It catalyzes the reduction of quinones, a class of molecules with diverse biological roles, using NADPH (nicotinamide adenine dinucleotide phosphate) as an electron donor. This reduction reaction is essential for the detoxification of various endogenous and exogenous compounds, including reactive oxygen species (ROS), electrophiles, and xenobiotics. NADPH:quinone reductase activity safeguards against oxidative stress by neutralizing ROS, preventing the accumulation of harmful reactive species. It also contributes to the detoxification of various toxins, drugs, and environmental pollutants, protecting cells from their damaging effects. Furthermore, NADPH:quinone reductase activity is involved in the activation of certain drugs, contributing to their therapeutic efficacy. This enzymatic activity is a vital component of the cellular defense system, ensuring the detoxification of harmful compounds and maintaining cellular homeostasis.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Quinone oxidoreductase | A quinone oxidoreductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08257] | Homo sapiens (human) |
| All-trans-retinol dehydrogenase [NAD(+)] ADH4 | An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08319] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tetramethylene sulfoxide | tetrahydrothiophenes | ||
| isovaleramide | isovaleramide: inhibits liver alcohol dehydrogenases | ||
| n-cyclohexylformamide | alicyclic compound; formamides | mouse metabolite | |
| n-benzylformamide | formamides | ||
| memoquin | memoquin: structure in first source | ||
| ARS-1620 | ARS-1620 : A qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. ARS-1620: covalent S-IIP G12C inhibitor for targeting of KRAS G12C mutant tumors | quinazolines | antineoplastic agent; antiviral agent; inhibitor |