Target type: molecularfunction
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]
Alcohol dehydrogenase (NAD+) activity, zinc-dependent, is a crucial enzyme activity involved in the oxidation of alcohols, primarily ethanol. This enzymatic process utilizes nicotinamide adenine dinucleotide (NAD+) as a cofactor and zinc ions as essential catalytic components. The mechanism involves the transfer of hydride ions (H-) from the alcohol substrate to NAD+, resulting in the formation of an aldehyde or ketone product and NADH. The zinc ion plays a critical role in facilitating this reaction by coordinating with the alcohol substrate and activating the NAD+ cofactor. This activity is vital for various metabolic pathways, including ethanol metabolism in the liver, detoxification of harmful alcohols, and the biosynthesis of steroids and fatty acids. In addition, alcohol dehydrogenase (NAD+) activity, zinc-dependent, is implicated in the pathogenesis of alcohol-related diseases, such as alcoholic liver disease and fetal alcohol syndrome.'
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Protein | Definition | Taxonomy |
---|---|---|
Alcohol dehydrogenase 1C | An alcohol dehydrogenase 1C that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00326] | Homo sapiens (human) |
Alcohol dehydrogenase class-3 | An alcohol dehydrogenase class-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11766] | Homo sapiens (human) |
Alcohol dehydrogenase 6 | An alcohol dehydrogenase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28332] | Homo sapiens (human) |
All-trans-retinol dehydrogenase [NAD | An all-trans-retinol dehydrogenase [NAD(+)] ADH7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40394] | Homo sapiens (human) |
All-trans-retinol dehydrogenase [NAD(+)] ADH4 | An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08319] | Homo sapiens (human) |
Alcohol dehydrogenase 1A | An alcohol dehydrogenase 1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07327] | Homo sapiens (human) |
All-trans-retinol dehydrogenase [NAD(+)] ADH1B | An all-trans-retinol dehydrogenase [NAD(+)] ADH1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00325] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
tetramethylene sulfoxide | tetrahydrothiophenes | ||
isovaleramide | isovaleramide: inhibits liver alcohol dehydrogenases | ||
n-cyclohexylformamide | alicyclic compound; formamides | mouse metabolite | |
n-benzylformamide | formamides | ||
n6022 | N6022: inhibits S-nitrosoglutathione reductase; structure in first source |