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alcohol dehydrogenase (NAD+) activity, zinc-dependent

Definition

Target type: molecularfunction

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]

Alcohol dehydrogenase (NAD+) activity, zinc-dependent, is a crucial enzyme activity involved in the oxidation of alcohols, primarily ethanol. This enzymatic process utilizes nicotinamide adenine dinucleotide (NAD+) as a cofactor and zinc ions as essential catalytic components. The mechanism involves the transfer of hydride ions (H-) from the alcohol substrate to NAD+, resulting in the formation of an aldehyde or ketone product and NADH. The zinc ion plays a critical role in facilitating this reaction by coordinating with the alcohol substrate and activating the NAD+ cofactor. This activity is vital for various metabolic pathways, including ethanol metabolism in the liver, detoxification of harmful alcohols, and the biosynthesis of steroids and fatty acids. In addition, alcohol dehydrogenase (NAD+) activity, zinc-dependent, is implicated in the pathogenesis of alcohol-related diseases, such as alcoholic liver disease and fetal alcohol syndrome.'
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Proteins (7)

ProteinDefinitionTaxonomy
Alcohol dehydrogenase 1CAn alcohol dehydrogenase 1C that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00326]Homo sapiens (human)
Alcohol dehydrogenase class-3An alcohol dehydrogenase class-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11766]Homo sapiens (human)
Alcohol dehydrogenase 6An alcohol dehydrogenase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28332]Homo sapiens (human)
All-trans-retinol dehydrogenase [NADAn all-trans-retinol dehydrogenase [NAD(+)] ADH7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40394]Homo sapiens (human)
All-trans-retinol dehydrogenase [NAD(+)] ADH4An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08319]Homo sapiens (human)
Alcohol dehydrogenase 1AAn alcohol dehydrogenase 1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07327]Homo sapiens (human)
All-trans-retinol dehydrogenase [NAD(+)] ADH1BAn all-trans-retinol dehydrogenase [NAD(+)] ADH1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00325]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
tetramethylene sulfoxidetetrahydrothiophenes
isovaleramideisovaleramide: inhibits liver alcohol dehydrogenases
n-cyclohexylformamidealicyclic compound;
formamides
mouse metabolite
n-benzylformamideformamides
n6022N6022: inhibits S-nitrosoglutathione reductase; structure in first source