quinone metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving quinone. [GOC:go_curators, GOC:pr, GOC:TermGenie]

Quinone metabolic process is a fundamental biochemical pathway that plays a crucial role in cellular respiration, detoxification, and the biosynthesis of various essential molecules. It involves the reduction and oxidation of quinones, which are organic compounds with a characteristic 1,4-diketone structure. Quinones act as electron carriers in the electron transport chain, transferring electrons from one molecule to another. This process is essential for generating ATP, the primary energy currency of cells. Quinones also participate in detoxification pathways, converting harmful molecules into less toxic forms. Furthermore, they are involved in the biosynthesis of various essential molecules, including vitamin K and ubiquinone. The quinone metabolic process can be broadly categorized into two major branches: the respiratory electron transport chain and the detoxification pathways. In the respiratory electron transport chain, quinones such as ubiquinone (CoQ) and menaquinone (vitamin K) shuttle electrons between protein complexes, ultimately leading to the production of ATP. Detoxification pathways involving quinones often involve the reduction of quinone substrates by specific enzymes such as NAD(P)H quinone oxidoreductase (NQO1). These enzymes catalyze the conversion of quinone molecules into hydroquinones, reducing their reactivity and toxicity. The quinone metabolic process is tightly regulated by various factors, including cellular redox state, nutrient availability, and environmental stress. Dysregulation of this process can lead to various human diseases, including cancer, heart disease, and neurodegenerative disorders. Therefore, understanding the intricate mechanisms of quinone metabolism is crucial for developing effective treatments for these diseases.'
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Proteins (1)

Compounds (4)