All-trans-retinol dehydrogenase [NAD

An all-trans-retinol dehydrogenase [NAD(+)] ADH7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40394]

Synonyms

EC 1.1.1.105;
Alcohol dehydrogenase class 4 mu/sigma chain;
1.1.1.1;
Alcohol dehydrogenase class IV mu/sigma chain;
Gastric alcohol dehydrogenase;
Omega-hydroxydecanoate dehydrogenase ADH7;
1.1.1.66;
Retinol dehydrogenase

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	2 (66.67)	18.7374
1990's	1 (33.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-cyclohexylformamide	Homo sapiens (human)	Ki	380.0000	1	1
n-benzylformamide	Homo sapiens (human)	Ki	11.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tetramethylene sulfoxide	Homo sapiens (human)	Kii	1,600.0000	1	1
isovaleramide	Homo sapiens (human)	Km	510.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
alcohol dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1]
alcohol dehydrogenase (NAD+) activity, zinc-dependent	molecular function	Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]
aldehyde oxidase activity	molecular function	Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. [EC:1.2.3.1]
all-trans-retinol dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. [RHEA:21284]
retinol binding	molecular function	Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. [GOC:curators]
ethanol binding	molecular function	Binding to ethanol, CH(3)-CH(2)-OH. [ISBN:0198506732]
receptor antagonist activity	molecular function	The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]
omega-hydroxydecanoate dehydrogenase activity	molecular function	Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH. [EC:1.1.1.66, RHEA:20880]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
retinoid metabolic process	biological process	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732]
response to bacterium	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]
fatty acid omega-oxidation	biological process	A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. [MetaCyc:PWY-2724, PMID:16404574]
response to ethanol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
retinoic acid metabolic process	biological process	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
retinol metabolic process	biological process	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]