All-trans-retinol dehydrogenase [NAD(+)] ADH1B

An all-trans-retinol dehydrogenase [NAD(+)] ADH1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00325]

EC 1.1.1.105;
Alcohol dehydrogenase 1B;
Alcohol dehydrogenase subunit beta

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-cyclohexylformamide	Homo sapiens (human)	Ki	3.4000	1	1
n-benzylformamide	Homo sapiens (human)	Ki	0.3300	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tetramethylene sulfoxide	Homo sapiens (human)	Kii	1,600.0000	1	1
isovaleramide	Homo sapiens (human)	Km	510.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
alcohol dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1]
alcohol dehydrogenase (NAD+) activity, zinc-dependent	molecular function	Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]
all-trans-retinol dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. [RHEA:21284]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 3 target(s):

Target	Category	Definition
retinoid metabolic process	biological process	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732]
retinoic acid metabolic process	biological process	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
retinol metabolic process	biological process	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]