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cellular aldehyde metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. [GOC:go_curators, ISBN:0198506732]

Cellular aldehyde metabolic process encompasses a wide range of reactions involving the conversion, degradation, and detoxification of aldehydes. These highly reactive molecules are generated as intermediates in various metabolic pathways, including lipid metabolism, amino acid catabolism, and alcohol metabolism. Aldehydes can be toxic to cells, leading to oxidative stress and damage to DNA, proteins, and lipids. Therefore, efficient mechanisms exist to regulate their levels and prevent their accumulation. Key enzymes involved in aldehyde metabolism include aldehyde dehydrogenases (ALDHs), alcohol dehydrogenases (ADHs), and aldehyde reductases. ALDHs catalyze the oxidation of aldehydes to carboxylic acids, a major detoxification pathway. ADHs can also oxidize certain aldehydes but primarily function in alcohol metabolism. Aldehyde reductases, on the other hand, reduce aldehydes to alcohols, playing a role in the biosynthesis of specific alcohols. The cellular aldehyde metabolic process is tightly regulated, with different enzymes exhibiting varying substrate specificities and tissue distribution. This ensures the efficient removal of toxic aldehydes while maintaining the necessary levels of essential aldehydes for cellular functions.'
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Proteins (3)

ProteinDefinitionTaxonomy
Aldehyde dehydrogenase, dimeric NADP-preferring An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30838]Homo sapiens (human)
All-trans-retinol dehydrogenase [NAD(+)] ADH4An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08319]Homo sapiens (human)
Retinal dehydrogenase 1An aldehyde dehydrogenase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00352]Homo sapiens (human)

Compounds (18)

CompoundDefinitionClassesRoles
4-nitrobenzaldehyde4-nitrobenzaldehyde : A C-nitro compound that is benzaldehyde substituted at the para-position with a nitro group.

4-nitrobenzaldehyde: RN given refers to parent cpd
benzaldehydes;
C-nitro compound
tetramethylene sulfoxidetetrahydrothiophenes
disulfiramorganic disulfide;
organosulfur acaricide
angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
perphenazineperphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.

Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
N-(2-hydroxyethyl)piperazine;
N-alkylpiperazine;
organochlorine compound;
phenothiazines
antiemetic;
dopaminergic antagonist;
phenothiazine antipsychotic drug
thiramthiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.

Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.
organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
cystamine dihydrochloride
uvitex swnUvitex SWN: optical brightner from Ciba; structure7-aminocoumarinsfluorochrome
bis(1-piperidylthiocarbonyl)disulfidebis(1-piperidylthiocarbonyl)disulfide: indicator for analysis of copper; structure
isovaleramideisovaleramide: inhibits liver alcohol dehydrogenases
n-cyclohexylformamidealicyclic compound;
formamides
mouse metabolite
win 18446WIN 18446 : A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish.organochlorine compound;
secondary carboxamide
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
4-(diethylamino)benzaldehyde4-(diethylamino)benzaldehyde : A member of the class of benzaldehydes carrying a diethylamino substituent at position 4.aromatic amine;
benzaldehydes;
tertiary amino compound
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
n-benzylformamideformamides
daidzindaidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).

daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative
plant metabolite
7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dionepiperazines
1-(4-chlorophenyl)sulfonyl-2-benzimidazolaminesulfonamide
2-acetylfuranonaphthoquinone2-acetylfuranonaphthoquinone: has antineoplastic activity; structure in first source
nct-501NCT-501: inhibits aldehyde dehydrogenase 1A1; structure in first source