alcohol dehydrogenase (NAD+) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1]

Alcohol dehydrogenase (NAD+) activity catalyzes the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. This process involves the transfer of two electrons and two protons from the alcohol substrate to the nicotinamide adenine dinucleotide (NAD+) cofactor, reducing NAD+ to NADH. The enzyme typically exhibits broad substrate specificity, accepting a variety of alcohols, including ethanol, methanol, and propanol. The reaction mechanism involves the formation of an enzyme-substrate complex, followed by the removal of a hydride ion from the alcohol by the NAD+ cofactor. The resulting aldehyde or ketone product is then released from the enzyme, while the reduced NADH cofactor dissociates and can be re-oxidized in subsequent metabolic reactions. Alcohol dehydrogenase (NAD+) activity plays a crucial role in various metabolic pathways, including the detoxification of alcohols in the liver, the biosynthesis of steroids, and the production of biofuels. Notably, the enzyme is responsible for the oxidation of ethanol to acetaldehyde, the first step in the metabolism of alcoholic beverages.'
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Proteins (7)

Compounds (6)