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alcohol dehydrogenase (NAD+) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1]

Alcohol dehydrogenase (NAD+) activity catalyzes the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. This process involves the transfer of two electrons and two protons from the alcohol substrate to the nicotinamide adenine dinucleotide (NAD+) cofactor, reducing NAD+ to NADH. The enzyme typically exhibits broad substrate specificity, accepting a variety of alcohols, including ethanol, methanol, and propanol. The reaction mechanism involves the formation of an enzyme-substrate complex, followed by the removal of a hydride ion from the alcohol by the NAD+ cofactor. The resulting aldehyde or ketone product is then released from the enzyme, while the reduced NADH cofactor dissociates and can be re-oxidized in subsequent metabolic reactions. Alcohol dehydrogenase (NAD+) activity plays a crucial role in various metabolic pathways, including the detoxification of alcohols in the liver, the biosynthesis of steroids, and the production of biofuels. Notably, the enzyme is responsible for the oxidation of ethanol to acetaldehyde, the first step in the metabolism of alcoholic beverages.'
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Proteins (7)

ProteinDefinitionTaxonomy
Dehydrogenase/reductase SDR family member 9A dehydrogenase/reductase SDR family member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BPW9]Homo sapiens (human)
All-trans-retinol dehydrogenase [NADAn all-trans-retinol dehydrogenase [NAD(+)] ADH7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40394]Homo sapiens (human)
Alcohol dehydrogenase 6An alcohol dehydrogenase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28332]Homo sapiens (human)
All-trans-retinol dehydrogenase [NAD(+)] ADH4An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08319]Homo sapiens (human)
Alcohol dehydrogenase 1AAn alcohol dehydrogenase 1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07327]Homo sapiens (human)
Alcohol dehydrogenase 1CAn alcohol dehydrogenase 1C that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00326]Homo sapiens (human)
All-trans-retinol dehydrogenase [NAD(+)] ADH1BAn all-trans-retinol dehydrogenase [NAD(+)] ADH1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00325]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
tetramethylene sulfoxidetetrahydrothiophenes
indomethacinindometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole
analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic;
xenobiotic metabolite
isovaleramideisovaleramide: inhibits liver alcohol dehydrogenases
n-cyclohexylformamidealicyclic compound;
formamides
mouse metabolite
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acidchromanol;
monocarboxylic acid;
phenols
antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
n-benzylformamideformamides