Compounds > n-cyclohexylformamide
Page last updated: 2024-12-05

n-cyclohexylformamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID13017
CHEMBL ID46778
CHEBI ID17945
SCHEMBL ID26146
SCHEMBL ID8759713
MeSH IDM0274669

Synonyms (46)

Synonym
n-cyclohexyl formamide
4-12-00-00038 (beilstein handbook reference)
x2cfe4sdt6 ,
unii-x2cfe4sdt6
CHEBI:17945 ,
n-zyklohexylformamid
n-formylcyclohexylamine
n-cyclohexylformamid
NCIOPEN2_000858
C0909
AE-646/31212051
brn 2040181
nsc 76127
ai3-16743
formamidocyclohexane
cyclohexylformamide
nsc76127
nsc-76127
formamide, n-cyclohexyl-
CXF ,
n-cyclohexylformamide ,
766-93-8
inchi=1/c7h13no/c9-6-8-7-4-2-1-3-5-7/h6-7h,1-5h2,(h,8,9
DB03559
n-cyclohexylformamide, 99%
n-cyclohexyl-formamide
CHEMBL46778 ,
BMSE000630
bdbm50064278
AKOS009158260
FT-0632914
SCHEMBL26146
3LJ7
DTXSID40227416
SCHEMBL8759713
mfcd00003828
n-cyclohexylmethanamide
formylaminocyclohexane
F1984-0356
formamide,n-cyclohexyl-
Q27094495
D89406
n-yclohexylformamide
n-?cyclohexylformamide
CS-0099360
SY051561
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
formamidesAmides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H).
alicyclic compoundAn aliphatic compound having a carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)IC50 (µMol)0.00460.00460.00460.0046AID977608
All-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)Ki3.40000.33001.86503.4000AID34040
Alcohol dehydrogenase 1CHomo sapiens (human)Ki5.20004.90005.05005.2000AID34041
Alcohol dehydrogenase E chainEquus caballus (horse)Ki8.70000.14122.89278.7000AID33860
Alcohol dehydrogenase S chainEquus caballus (horse)Ki8.70000.14122.89278.7000AID33860
Alcohol dehydrogenase 1AHomo sapiens (human)Ki2.30002.30002.30002.3000AID34039
Retinal dehydrogenase 1 Rattus norvegicus (Norway rat)Ki2.30002.30002.30002.3000AID34039
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (12)

Processvia Protein(s)Taxonomy
retinoid metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
retinoic acid metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
retinol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
retinoic acid metabolic processAlcohol dehydrogenase 1CHomo sapiens (human)
retinol metabolic processAlcohol dehydrogenase 1CHomo sapiens (human)
alcohol metabolic processAlcohol dehydrogenase 1AHomo sapiens (human)
retinoic acid metabolic processAlcohol dehydrogenase 1AHomo sapiens (human)
retinol metabolic processAlcohol dehydrogenase 1AHomo sapiens (human)
retinoid metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
ethanol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cellular aldehyde metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
fatty acid omega-oxidationAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
retinol metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol catabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
quinone metabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
formaldehyde catabolic processAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
retinoid metabolic processAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
response to bacteriumAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
fatty acid omega-oxidationAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
response to ethanolAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
retinoic acid metabolic processAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
retinol metabolic processAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
alcohol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
zinc ion bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
alcohol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1CHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1CHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAlcohol dehydrogenase 1CHomo sapiens (human)
zinc ion bindingAlcohol dehydrogenase 1CHomo sapiens (human)
alcohol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1AHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAlcohol dehydrogenase 1AHomo sapiens (human)
protein bindingAlcohol dehydrogenase 1AHomo sapiens (human)
butanol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1AHomo sapiens (human)
zinc ion bindingAlcohol dehydrogenase 1AHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAlcohol dehydrogenase 1AHomo sapiens (human)
NADPH:quinone reductase activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
aldose reductase (NADPH) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
all-trans retinal bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
protein bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
zinc ion bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
benzaldehyde dehydrogenase [NAD(P)+] activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
retinol bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
NAD bindingAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activityAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
alcohol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
alcohol dehydrogenase (NAD+) activity, zinc-dependentAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
aldehyde oxidase activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
all-trans-retinol dehydrogenase (NAD+) activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
retinol bindingAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
ethanol bindingAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
receptor antagonist activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
omega-hydroxydecanoate dehydrogenase activityAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
zinc ion bindingAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
nucleoplasmAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
plasma membraneAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH1BHomo sapiens (human)
nucleoplasmAlcohol dehydrogenase 1CHomo sapiens (human)
cytosolAlcohol dehydrogenase 1CHomo sapiens (human)
plasma membraneAlcohol dehydrogenase 1CHomo sapiens (human)
cytosolAlcohol dehydrogenase 1CHomo sapiens (human)
nucleoplasmAlcohol dehydrogenase 1AHomo sapiens (human)
cytosolAlcohol dehydrogenase 1AHomo sapiens (human)
plasma membraneAlcohol dehydrogenase 1AHomo sapiens (human)
cytosolAlcohol dehydrogenase 1AHomo sapiens (human)
nucleoplasmAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NAD(+)] ADH4Homo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
plasma membraneAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
cytosolAll-trans-retinol dehydrogenase [NADHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID977608Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB2010Journal of molecular biology, Jul-23, Volume: 400, Issue:4
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
AID34042Inhibition of human alcohol dehydrogenase pi activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34039Inhibition of human alcohol dehydrogenase alpha activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34044Inhibition of human alcohol dehydrogenase sigma activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34040Inhibition of human alcohol dehydrogenase beta 1 activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID34041Inhibition of human alcohol dehydrogenase gamma2 activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
AID33860Inhibition of horse liver alcohol dehydrogenase activity1998Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
Inhibition of human alcohol dehydrogenases by formamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.87 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		210elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
12-hydroxydodecanoic acid
12-hydroxylauric acid : A medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid.		210omega-hydroxy-medium-chain fatty acidhuman metabolite
n-benzylformamide
[no description available]		1.9910formamides
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		7.6930organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
piperidines
Piperidines: A family of hexahydropyridines.		2.420
ConditionIndicatedRelationship StrengthStudiesTrials