lgd-2226 and Hypogonadism

lgd-2226 has been researched along with Hypogonadism* in 2 studies

Other Studies

2 other study(ies) available for lgd-2226 and Hypogonadism

ArticleYear
Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones.
    Bioorganic & medicinal chemistry letters, 2007, Mar-15, Volume: 17, Issue:6

    A series of selective androgen receptor modulators (SARMs) with a wide spectrum of receptor modulating activities was developed based on optimization of the 4-substituted 6-bisalkylamino-2-quinolinones (3). Significance of the trifluoromethyl group on the side chains and its interactions with amino acid residues within the androgen receptor (AR) ligand binding domain are discussed. A representative analog (9) was tested orally in a rodent model of hypogonadism and demonstrated desirable tissue selectivity.

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Binding, Competitive; Dihydrotestosterone; Genitalia, Male; Hypogonadism; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Molecular Conformation; Orchiectomy; Organ Size; Organ Specificity; Prostate; Quinolines; Rats; Receptors, Androgen; Structure-Activity Relationship; Transfection

2007
Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.
    Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21

    The androgen receptor is a ligand inducible transcription factor that is involved in a broad range of physiological functions. Here we describe the discovery of a new class of orally available selective androgen receptor modulators. The lead compound, 6-[(2R,5R)-2-methyl-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-4-trifluoromethylquinolin-2(1H)-one (6a), showed excellent anabolic activity in muscle with reduced effect on the prostate in a rat model of hypogonadism. The compound also improved bone strength in a rat model of post-menopausal osteoporosis.

    Topics: Administration, Oral; Anabolic Agents; Androgen Receptor Antagonists; Androgens; Animals; Biological Availability; Bone Density Conservation Agents; Female; Humans; Hypogonadism; Male; Muscle, Skeletal; Organ Size; Osteoporosis, Postmenopausal; Prostate; Pyrrolidines; Quinolines; Quinolones; Rats; Stereoisomerism; Structure-Activity Relationship

2007