tubulysin D: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 12134546 |
| CHEMBL ID | 455213 |
| CHEBI ID | 80036 |
| SCHEMBL ID | 12219631 |
| MeSH ID | M0487444 |
| Synonym |
|---|
| tubulysin d |
| CHEMBL455213 |
| chebi:80036 , |
| SCHEMBL12219631 |
| 309935-57-7 |
| bdbm50483306 |
| benzenepentanoic acid, .gamma.-(((2-((1r,3r)-1-(acetyloxy)-4-methyl-3-(((2s,3s)-3-methyl-2-((((2r)-1-methyl-2-piperidinyl)carbonyl)amino)-1-oxopentyl)((3-methyl-1-oxobutoxy)methyl)amino)pentyl)-4-thiazolyl)carbonyl)amino)-.alpha.-methyl-, (.alpha.s,.gamma |
| Q27149183 |
| qka34pe4db , |
| benzenepentanoic acid, gamma-(((2-((1r,3r)-1-(acetyloxy)-4-methyl-3-(((2s,3s)-3-methyl-2-((((2r)-1-methyl-2-piperidinyl)carbonyl)amino)-1-oxopentyl)((3-methyl-1-oxobutoxy)methyl)amino)pentyl)-4-thiazolyl)carbonyl)amino)-alpha-methyl-, (alphas,.gamm |
| (+)-tubulysin d |
| unii-qka34pe4db |
| HY-N2348 |
| CS-0021785 |
| (2s,4r)-4-[[2-[(1r,3r)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2s,3s)-3-methyl-2-[[(2r)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-2-methyl-5-phenylpentanoic acid |
| AKOS040740474 |
| EX-A5466D |
| Class | Description |
|---|---|
| diester | A diester is a compound containing two ester groups. |
| carboxylic acid | A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 (µMol) | 1.7000 | 0.0067 | 2.1603 | 10.0000 | AID551268 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 (µMol) | 1.7000 | 0.0067 | 2.1374 | 10.0000 | AID551268 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID551270 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. |
| AID551268 | Inhibition of porcine brain tubulin polymerization by microtubule assembly assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. |
| AID551272 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. |
| AID551269 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. |
| AID551271 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. |
| AID411784 | Anticancer activity against human KBV1 cells expressing P-gp | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues. |
| AID326222 | Anticancer activity against multidrug-resistant human KBV1 cells | 2008 | Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6 | Cytotoxic simplified tubulysin analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.76) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||