tubulysin d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tubulysin D: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	12134546
CHEMBL ID	455213
CHEBI ID	80036
SCHEMBL ID	12219631
MeSH ID	M0487444

Synonyms (17)

Synonym
tubulysin d
CHEMBL455213
chebi:80036 ,
SCHEMBL12219631
309935-57-7
bdbm50483306
benzenepentanoic acid, .gamma.-(((2-((1r,3r)-1-(acetyloxy)-4-methyl-3-(((2s,3s)-3-methyl-2-((((2r)-1-methyl-2-piperidinyl)carbonyl)amino)-1-oxopentyl)((3-methyl-1-oxobutoxy)methyl)amino)pentyl)-4-thiazolyl)carbonyl)amino)-.alpha.-methyl-, (.alpha.s,.gamma
Q27149183
qka34pe4db ,
benzenepentanoic acid, gamma-(((2-((1r,3r)-1-(acetyloxy)-4-methyl-3-(((2s,3s)-3-methyl-2-((((2r)-1-methyl-2-piperidinyl)carbonyl)amino)-1-oxopentyl)((3-methyl-1-oxobutoxy)methyl)amino)pentyl)-4-thiazolyl)carbonyl)amino)-alpha-methyl-, (alphas,.gamm
(+)-tubulysin d
unii-qka34pe4db
HY-N2348
CS-0021785
(2s,4r)-4-[[2-[(1r,3r)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2s,3s)-3-methyl-2-[[(2r)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-2-methyl-5-phenylpentanoic acid
AKOS040740474
EX-A5466D

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
diester	A diester is a compound containing two ester groups.
carboxylic acid	A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tubulin alpha-1A chain	Sus scrofa (pig)	IC50 (µMol)	1.7000	0.0067	2.1603	10.0000	AID551268
Tubulin beta chain	Sus scrofa (pig)	IC50 (µMol)	1.7000	0.0067	2.1374	10.0000	AID551268
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID551270	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
AID551268	Inhibition of porcine brain tubulin polymerization by microtubule assembly assay	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
AID551272	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
AID551269	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
AID551271	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
AID411784	Anticancer activity against human KBV1 cells expressing P-gp	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.
AID326222	Anticancer activity against multidrug-resistant human KBV1 cells	2008	Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6	Cytotoxic simplified tubulysin analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (66.67)	29.6817
2010's	4 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.76 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.76)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.44	2	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	2.44	2	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
citronellol citronellol: alcohol form of citronellal; found in rose oil; RN given refers to parent cpd without isomeric designation; structure. citronellol : A monoterpenoid that is oct-6-ene substituted by a hydroxy group at position 1 and methyl groups at positions 3 and 7.. insect repellent : An insecticide that acts as a repellent to insects.	2.05	1	monoterpenoid	plant metabolite
aziridine [no description available]	2.05	1	azacycloalkane; aziridines; saturated organic heteromonocyclic parent	alkylating agent
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	2.04	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
vinblastine [no description available]	2.06	1
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	2.05	1
oxazolidin-2-one Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.	2.05	1	carbamate ester; oxazolidinone	metabolite
gulose gulose: RN given refers to cpd without isomeric designation. gulopyranose : The pyranose form of gulose.. gulose : An aldohexose that is the C-3 epimer of galactose.	2.05	1	D-aldohexose; D-gulose; gulopyranose
fosbretabulin [no description available]	2.04	1	stilbenoid
hti-286 HTI-286: a synthetic analog of the tripeptide hemiasterlin; structure in first source	2.45	2
tubulysin a tubulysin A: has both antiangiogenic and antineoplastic activities; structure in first source	2.04	1	carboxylic acid; diester
tubulysin u tubulysin U: structure in first source	2.77	3
tubulysin v tubulysin V: structure in first source	2.77	3
pretubulysin pretubulysin: from myxobacteria; structure in first source	2.17	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.17	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.17	1
Cancer of Colon [description not available]	2.06	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.06	1
Colorectal Cancer [description not available]	2.06	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.06	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.06	1

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