hti-286 and Melanoma

hti-286 has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for hti-286 and Melanoma

Article	Year
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents. Bioorganic & medicinal chemistry letters, 2004, Aug-16, Volume: 14, Issue:16 Modifications of the B-segment of HTI-286 (2) produced a class of analogs incorporating heteroatom-substituents. The structure-activity relationship was studied. Analogs bearing methylsulfide and fluoride groups exhibited potency comparable to that of the parent compound HTI-286 and to paclitaxel in cytotoxicity assays against KB-3-1 cell lines. These analogs were more potent than paclitaxel against P-glycoprotein expressing KB-8-5 and KB-V1 cell lines. Several analogs showed strong inhibition of tubulin polymerization. Topics: Cell Line; Humans; Melanoma; Oligopeptides; Structure-Activity Relationship; Transplantation, Heterologous; Tubulin Modulators	2004

Article

Year

Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.

Bioorganic & medicinal chemistry letters, 2004, Aug-16, Volume: 14, Issue:16

Modifications of the B-segment of HTI-286 (2) produced a class of analogs incorporating heteroatom-substituents. The structure-activity relationship was studied. Analogs bearing methylsulfide and fluoride groups exhibited potency comparable to that of the parent compound HTI-286 and to paclitaxel in cytotoxicity assays against KB-3-1 cell lines. These analogs were more potent than paclitaxel against P-glycoprotein expressing KB-8-5 and KB-V1 cell lines. Several analogs showed strong inhibition of tubulin polymerization.

Topics: Cell Line; Humans; Melanoma; Oligopeptides; Structure-Activity Relationship; Transplantation, Heterologous; Tubulin Modulators

2004