ge-2270-a and acetamide

ge-2270-a has been researched along with acetamide* in 1 studies

Other Studies

1 other study(ies) available for ge-2270-a and acetamide

Article	Year
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1. Chemistry, an Asian journal, 2008, Feb-01, Volume: 3, Issue:2 The total syntheses of the thiopeptide antibiotics GE2270A (7), GE2270T (8), and GE2270C1 (9) are described. The original synthetic strategies employed utilized the hetero-Diels-Alder reaction to construct the pyridine core of the target molecules and relied on a macrolactamization process to construct the macrocycle. The hetero-Diels-Alder-based strategy finally evolved allows the introduction of all four thiazole units attached to the pyridine ring and a one-pot sequence for macrocyclization and side-chain extension, culminating in highly convergent and expedient syntheses of these molecules as exemplified by a 24-step synthesis of GE2270C1 (9). Topics: Acetamides; Anti-Bacterial Agents; Azoles; Hydroxylation; Macrolides; Molecular Structure; Peptides, Cyclic; Phenylalanine; Pyridines; Sulfhydryl Compounds; Thiazoles	2008

Article

Year

Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.

Chemistry, an Asian journal, 2008, Feb-01, Volume: 3, Issue:2

The total syntheses of the thiopeptide antibiotics GE2270A (7), GE2270T (8), and GE2270C1 (9) are described. The original synthetic strategies employed utilized the hetero-Diels-Alder reaction to construct the pyridine core of the target molecules and relied on a macrolactamization process to construct the macrocycle. The hetero-Diels-Alder-based strategy finally evolved allows the introduction of all four thiazole units attached to the pyridine ring and a one-pot sequence for macrocyclization and side-chain extension, culminating in highly convergent and expedient syntheses of these molecules as exemplified by a 24-step synthesis of GE2270C1 (9).

Topics: Acetamides; Anti-Bacterial Agents; Azoles; Hydroxylation; Macrolides; Molecular Structure; Peptides, Cyclic; Phenylalanine; Pyridines; Sulfhydryl Compounds; Thiazoles

2008