Compounds > thiomuracin a
Page last updated: 2024-11-13

thiomuracin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thiomuracin A: isolated from Nonomurae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID57783710
CHEMBL ID2164774
SCHEMBL ID13787925
MeSH IDM0578678

Synonyms (3)

Synonym
CHEMBL2164774
thiomuracin a
SCHEMBL13787925
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID698373Antibacterial activity against Streptococcus pyogenes ATCC BAA-595 by broth microdilution method2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698369Solubility of the compound in DMF solution2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698389Chemical stability of the compound in MeOH at 50 degC2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698385Chemical stability of the compound in HCl at room temperature2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698387Chemical stability of the compound in water at room temperature2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698372Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate AKH Vienna A4.018 by broth microdilution method2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698368Solubility of the compound in DMSO solution2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698371Antibacterial activity against Enterococcus faecium 7130724 by broth microdilution method2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698386Chemical stability of the compound in MeOH at room temperature2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698390Chemical stability of the compound in water at 50 degC2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698370Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698374Antibacterial activity against Clostridium difficile ATCC 43255 by broth microdilution method2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
AID698388Chemical stability of the compound in HCl at 50 degC2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (77.78)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.21 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		3.6920elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
thiazoles
[no description available]		5.37901,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
2'-deoxyadenosine
2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source		2.1510purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
s-adenosylhomocysteine
S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.		2.1510adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
thiocillin
thiocillin: closely related to microccin P; RN given refers to mono-Na salt(2S-(2alpha,5alpha,6beta(Z)))-isomer		3.7320azamacrocycle;
lactam
cc 1065
CC 1065: from Streptomyces zelensis; structure in second sourc		3.3510
fr 900848
FR 900848: from Streptovericillium fervens; structure given in first source. jawsamycin : A polyketide that is 5'-amino-5'-deoxy-3,4,5,6-tetrahydrouridine in which one of the hydrogens of the amino group is substituted by a (1E,3E)-1-[(1R,1'R,1''R,1'''R,2S,2'R,2''R,2'''S)-2'''-{(E)-2-[(1R,2R)-2-methylcyclopropyl]ethenyl}[1,1':2',1'':2'',1'''-quater(cyclopropan)]-2-yl]-5-oxopenta-1,3-dien-5-yl group. It is a metabolite isolated from the bacterium, Streptoverticillium fervens and targets the catalytic subunit of the fungal UDP-glycosyltransferase, the first step in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. It exhibits broad spectrum antifungal activity against several pathogenic fungi including Mucorales.		3.3510cyclopropanes;
nucleoside analogue;
olefinic compound;
polyketide;
secondary carboxamide		antifungal agent;
bacterial metabolite
nosiheptide
nosiheptide: from Streptomyces actuosus; structure		3.3510polyol
ly-146032
[no description available]		2.0710heterodetic cyclic peptide;
lipopeptide antibiotic;
lipopeptide;
macrocycle;
macrolide		antibacterial drug;
bacterial metabolite;
calcium-dependent antibiotics
ge 2270 a
GE 2270 A: from Planobispora rosea; inhibits bacterial protein synthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu; structure given in first source		2.1510
s-adenosylmethionine
(R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.		3.9730organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
heme
Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.		3.3510
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Infections, Gram-Positive
[description not available]		02.0710
Gram-Positive Bacterial Infections
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.		02.0710
Clostridioides difficile Infection
[description not available]		02.1310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1310
Clostridium Infections
Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species.		02.1310