2-hydroxy-1,4-benzoxazin-3-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-hydroxy-1,4-benzoxazin-3-one: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

HBOA : A benzoxazine bearing hydroxy and oxo substituents at positions 2 and 3 respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	322636
CHEMBL ID	457386
CHEBI ID	63559
SCHEMBL ID	912962
MeSH ID	M0401661

Synonyms (22)

Synonym
nsc280714
23520-34-5
nsc-280714
2-hydroxy-2h-1,4-benzoxazin-3(4h)-one
2-hydroxy-1,4-benzoxazin-3-one
hboa
inchi=1/c8h7no3/c10-7-8(11)12-6-4-2-1-3-5(6)9-7/h1-4,8,11h,(h,9,10
CHEMBL457386
chebi:63559 ,
2-hydroxy-4h-1,4-benzoxazin-3-one
2-hydroxy-4h-[1,4]benzoxazin-3-one
SCHEMBL912962
AKOS024287938
2-hydroxy-3,4-dihydro-2h-1,4-benzoxazin-3-one
(r)-2-hydroxy-2h-1,4-benzoxazin-3(4h)-one
DTXSID00314114
Z984801448
Q27132690
hboa;2-hydroxy-1,4-benzoxazin-3-one
BCP31437
2h-1,4-benzoxazin-3(4h)-one, 2-hydroxy-
EN300-65795

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

Role	Description
allelochemical	A class of secondary metabolites developed by many plants to influence the behaviour, growth or survival of herbivores, and thus acting as a defence against herbivory.
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

Class	Description
benzoxazine
lactam	Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
lactol	Cyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

Pathway	Proteins	Compounds
DIBOA-glucoside biosynthesis	7	13
superpathway of benzoxazinoid glucosides biosynthesis	9	20
superpathway of benzoxazinoid glucosides biosynthesis	10	20
DIBOA-glucoside biosynthesis	8	13

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID338669	Antiinflammatory activity in Wistar rat peritoneal mast cells assessed as inhibition of IgE-induced histamine release at 1000 uM treated 10 mins before IgE challenge measured after 5 mins
AID338668	Antiinflammatory activity in Wistar rat peritoneal mast cells assessed as inhibition of concanavalin A-induced histamine release at 1000 uM treated 10 mins before concanavalin A challenge measured after 30 mins
AID1103171	Antifeedant activity against third-instar larvae of Rhopalosiphum padi assessed as repellency index after 24 hr by feeding choice assay	2004	Journal of agricultural and food chemistry, May-05, Volume: 52, Issue:9	Chemical basis for the antifeedant activity of natural hydroxamic acids and related compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (66.67)	29.6817
2010's	2 (22.22)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.81 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.81)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one: from maize extracts; structure given in first source. DIMBOA : A lactol that is DIBOA in which the hydrogen at position 7 is replaced by a methoxy group. It has been isolated from the maize plants.	3.81	3	aromatic ether; benzoxazine; cyclic hydroxamic acid; lactol	allelochemical; plant metabolite
galactose galactopyranose : The pyranose form of galactose.	2.25	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
benzoxazolone benzoxazolone: RN given refers to parent cpd; structure. 2-benzoxazolinone : A member of the class of benzoxazoles that is 2,3-dihydro-1,3-benzoxazole carrying an oxo group at position 2.	2.01	1	benzoxazole	allelochemical; phytoalexin
3-hydroxy-2-oxoindole 3-hydroxyindolin-2-one: structure in first source. 3-hydroxyindolin-2-one : An oxindole that is 1,3-dihydro-2H-indol-2-one substituted by a hydroxy group at position 3.	2	1	hydroxyindoles; oxindoles
benzoxazoles 1,3-benzoxazole : A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.. benzoxazole : Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton.	2.42	2	1,3-benzoxazoles; mancude organic heterobicyclic parent
6-methoxybenzoxazolinone 6-methoxybenzoxazolinone: plant derivative which stimulates reproduction in Microtus montanus. 6-methoxy-2-benzoxazolinone : A 2-benzoxazolinone that is substituted by a methoxy group at position 6.	2.03	1	aromatic ether; benzoxazole	antibacterial agent; anticonvulsant; antifungal agent; muscle relaxant; plant metabolite
2,4-dihydroxy-1,4-benzoxazin-3-one 2,4-dihydroxy-1,4-benzoxazin-3-one: structure in first source. DIBOA : A lactol that consists of 1,4-benzoxazine bearing two hydroxy substituents at positions 2 and 4 as well as a keto group at position 3.	2.73	3	benzoxazine; cyclic hydroxamic acid; lactol	allelochemical; herbicide; phytotoxin; plant metabolite
2-hydroxy-7-methoxy-2h-1,4-benzoxazin-3-one 2-hydroxy-7-methoxy-2H-1,4-benzoxazin-3-one: structure given in first source	2.43	2	benzoxazine
indoleglycerol phosphate indoleglycerol phosphate: inducer of tryptophan synthase. (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate : The (1S,2R)-diastereomer of 1-C-(indol-3-yl)glycerol 3-phosphate.	3.1	1	1-C-(indol-3-yl)glycerol 3-phosphate
glycosides [no description available]	2.08	1

Condition	Indicated	Relationship Strength	Studies	Trials
Acute Liver Injury, Drug-Induced [description not available]	0	2.25	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	0	2.25	1	0

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