| Assay ID | Title | Year | Journal | Article |
|---|
| AID274396 | Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists. |
| AID274390 | Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists. |
| AID260388 | Displacement of [3H]diprenorphine from human cloned delta opioid receptor | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists. |
| AID274417 | Antagonist activity against human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S binding | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. |
| AID223591 | Tested for the antagonism of kappa opioid receptor diuresis at a dose of 0.08 mg/kg subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID223587 | Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissue | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID224574 | Binding affinity was determined against Mu opioid receptor using [3H]-Naltrexone as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. |
| AID260386 | Displacement of [3H]diprenorphine from human cloned mu opioid receptor | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists. |
| AID148019 | Binding affinity at cloned human kappa opioid receptor by [3H]diprenorphine displacement. | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. |
| AID274391 | Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists. |
| AID149274 | Binding affinity was determined against Opioid receptor kappa 1
using [3H]ethylketocyclazocine as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. |
| AID148251 | Concentration required to inhibit the binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human delta opioid receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. |
| AID260389 | Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists. |
| AID148709 | Binding affinity against Opioid receptor kappa 1 using [3H]ethylketocyclazocine as radioligand. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists. |
| AID224718 | Binding affinity towards mu opioid receptor by displacement of [3H]NAL from rat brain homogenates | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID223589 | Antagonism of opioid analgesia using a mouse writhing model to block U-50,488 (2.5 mg/kg) induced kappa-opioid receptor subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID274411 | Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. |
| AID274412 | Displacement of [3H]diprenorphine from human cloned kappa opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. |
| AID152067 | Binding affinity against Opioid receptor mu 1 using [3H]naloxone as radioligand. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists. |
| AID274392 | Displacement of [3H]diprenorphine from human cloned delta opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists. |
| AID260387 | Displacement of [3H]diprenorphine from human cloned kappa opioid receptor | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists. |
| AID274413 | Displacement of [3H]diprenorphine from human cloned delta opioid receptor expressed in CHO cells | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
| Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. |
| AID150821 | Concentration required to inhibit agonist (loperamide) stimulated [35S]GTP-gamma-S, binding to membranes containing the cloned human mu opioid receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. |
| AID150990 | Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. |
| AID224715 | Antagonism of opioid analgesia using a mouse writhing model to block morphine (2.5 mg/kg) induced mu-opioid receptor (subcutaneously dosed) | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |