| Assay ID | Title | Year | Journal | Article |
|---|
| AID223591 | Tested for the antagonism of kappa opioid receptor diuresis at a dose of 0.08 mg/kg subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID223596 | Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissue | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
| AID1125186 | Agonist activity at human mu opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding at 10 uM | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID595126 | Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE stimulated [35S]GTPgammaS binding | 2010 | ACS medicinal chemistry letters, Oct-14, Volume: 1, Issue:7
| 1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists. |
| AID1125191 | Analgesic activity in mouse assessed as antagonism of U50488-induced antinociception by writhing test | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID152067 | Binding affinity against Opioid receptor mu 1 using [3H]naloxone as radioligand. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists. |
| AID224715 | Antagonism of opioid analgesia using a mouse writhing model to block morphine (2.5 mg/kg) induced mu-opioid receptor (subcutaneously dosed) | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID595127 | Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593 stimulated [35S]GTPgammaS binding | 2010 | ACS medicinal chemistry letters, Oct-14, Volume: 1, Issue:7
| 1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists. |
| AID223599 | Antagonist activity towards U50 488 induced kappa opioid receptor by mouse writhing assay at 2.5 mg/kg subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
| AID223587 | Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissue | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID1125178 | Antagonist activity at human mu opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID1125188 | Agonist activity at human delta opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding at 10 uM | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID1125179 | Antagonist activity at human kappa opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID224576 | Antagonistic activity towards morphine induced mu-opioid receptor by mouse writhing assay at 1.25 mg/kg subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
| AID224587 | Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenates | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
| AID176827 | Tested for concentration required to reduce the food consumption by 20 % subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
| AID149274 | Binding affinity was determined against Opioid receptor kappa 1
using [3H]ethylketocyclazocine as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. |
| AID223589 | Antagonism of opioid analgesia using a mouse writhing model to block U-50,488 (2.5 mg/kg) induced kappa-opioid receptor subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID1125180 | Antagonist activity at human delta opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID148709 | Binding affinity against Opioid receptor kappa 1 using [3H]ethylketocyclazocine as radioligand. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists. |
| AID223601 | Antagonism of bremazocine induced kappa receptor diuresis in rats at a concentration of 0.08 mg/kg subcutaneously | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
| AID1125187 | Agonist activity at human kappa opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding at 10 uM | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID1125190 | Analgesic activity in mouse assessed as antagonism of morphine-induced antinociception by writhing test | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. |
| AID224718 | Binding affinity towards mu opioid receptor by displacement of [3H]NAL from rat brain homogenates | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
| Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. |
| AID224574 | Binding affinity was determined against Mu opioid receptor using [3H]-Naltrexone as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 8, Issue:22
| N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. |
| AID595125 | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO stimulated [35S]GTPgammaS binding | 2010 | ACS medicinal chemistry letters, Oct-14, Volume: 1, Issue:7
| 1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |