| Assay ID | Title | Year | Journal | Article |
|---|
| AID141633 | Antinociceptive activity at mu opioid receptor from beta-funaltrexamine (beta-FNA) at the dose of 10 umol/kg (sc) | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID430089 | Displacement of [3H]NTI from Hartley guinea pig delta opioid receptor by liquid scintillation counter | 2009 | Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
| Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative. |
| AID149104 | Antinociceptive potency at Opioid receptor delta 1 antagonist 7-benzylidenenaltrexone (BNTX) at the dose of 1.3 umol/kg (sc) | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID79053 | Antagonist activity against electrically stimulated guinea pig ileum using ethylketazocine (EK) as kappa opioid receptor agonist | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID152081 | The compound tested for agonistic activity against Opioid receptor mu 1 using [3H]- DAMGO as the radioligand. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID147830 | Antinociceptive activity at Opioid receptor delta 2 antagonist naltriben (NTB) at the dose of 1.3 umol/kg (sc) | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID152386 | Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID149555 | selective binding affinity against kappa opioid receptor, using [3H]U-69593 as radioligand | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID149094 | Inhibition of [3H]-NTI binding to Opioid receptor delta 1 from mouse brain membranes. | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID430088 | Displacement of [3H]DAMGO from Hartley guinea pig mu opioid receptor by liquid scintillation counter | 2009 | Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
| Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative. |
| AID310938 | Agonist activity at rat delta opioid receptor expressed in C6 cells assessed as stimulation of [35S]GTP-gamma-S binding relative to BW373U86 | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity. |
| AID133509 | Antinociceptive activity at kappa opioid receptor antagonist norbinaltorphimine (norBNI) at the dose of 12 umol/kg (sc) | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID150098 | The compound tested for agonistic activity against Opioid receptor delta 1 using [3H]- NT1 as the radioligand. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID148584 | Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID114324 | Antinociceptive potency in mice using the tail-flick test on icv administration. | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID149472 | Antagonistic activity expressed as IC50 ratio in Opioid receptor mu 1 in electrically stimulated guinea pig ileum(GPI) | 1998 | Journal of medicinal chemistry, Jul-02, Volume: 41, Issue:14
| 14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors. |
| AID79054 | Antagonist activity against electrically stimulated guinea pig ileum using morphine (M) as mu opioid receptor agonist | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID148667 | Ability to inhibit binding of DADLE to Opioid receptor delta 1 was determined using mouse vas deferens; e = indicates not determined | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID79372 | Agonist activity expressed as percent inhibition of contraction of electrically stimulated guinea pig ileal longitudinal muscle at a concentration of 1 uM | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID151270 | Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from mouse brain membranes. | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID148718 | The compound tested for agonistic activity against Opioid receptor kappa 1 as the [3H]- U-69,594 radioligand. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID148695 | Ability to inhibit binding of ethylketazocine to Opioid receptor kappa 1 was determined using guinea pig ileal longitudinal muscle | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID148319 | Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 from mouse brain membranes. | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID430090 | Displacement of [3H]U69493 from Hartley guinea pig kappa opioid receptor by liquid scintillation counter | 2009 | Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
| Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative. |
| AID150038 | Selective binding affinity against Opioid receptor delta 1, using [3H]DPDPE as radioligand | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID148586 | Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID79207 | Compound was tested for agonistic activity on the electrically stimulated guinea pig ileum (GPI) at 1 uM | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID149086 | Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID148585 | Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID147827 | Selective binding affinity against Opioid receptor delta 2, using [3H]DSLET as radioligand | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID132332 | Agonist vas deferens(MVD) | 1998 | Journal of medicinal chemistry, Jul-02, Volume: 41, Issue:14
| 14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors. |
| AID138336 | Agonist activity expressed as inhibitory concentration against contraction of electrically stimulated mouse vas deferens | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID141515 | selective binding affinity against mu opioid receptor, using [3H]DAMGO as radioligand | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. |
| AID152389 | Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID149874 | Ability to inhibit binding of morphine to Opioid receptor mu 1 was determined using guinea pig ileal longitudinal muscle | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
| AID138341 | Compound was tested for agonistic activity on the electrically stimulated mouse vas deferens (MVD) | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
| AID152388 | Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| AID148698 | Antagonistic activity expressed as IC50 ratio against ethylketazocine (EK) Opioid receptor kappa 1 in smooth muscle preparations | 1998 | Journal of medicinal chemistry, Jul-02, Volume: 41, Issue:14
| 14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors. |
| AID310939 | Displacement of [3H]naltrindole from rat delta opioid receptor expressed in C6 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity. |
| AID78077 | Agonist activity (ability to decrease the twitch height of the electrically stimulated smooth muscle) in electrically stimulated guinea pig ileum(GPI) | 1998 | Journal of medicinal chemistry, Jul-02, Volume: 41, Issue:14
| 14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors. |
| AID149085 | Displacement of [3H]- diprenorphine from delta receptor expressed in HEK 293 cells | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |