Compounds > roridin e
Page last updated: 2024-11-13

roridin e

Description

roridin E: RN given refers to (2'E,7'R(R))-isomer; see also roridin J: 74042-83-6 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44593339
CHEMBL ID509175
SCHEMBL ID258643
MeSH IDM0044910

Synonyms (14)

Synonym
16891-85-3
roridin e
verrucarin a, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxyethyl)-, (2'e,7'r(r))-
verrucarin a, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-((1r)-1-hydroxyethyl)-, (2'e,7'r)-
roridine e
CHEMBL509175
unii-98826fbf79
98826fbf79 ,
verrucarin a, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-[(1r)-1-hydroxyethyl]-, (2'e,7'r)-
SCHEMBL258643
mfcd01675256
Q27272100
(1r,3r,8r,12e,17r,18e,20z,24r,25s,26s)-17-[(1r)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,12,18,20-tetraene-26,2'-oxirane]-11,22-dione
DTXSID501034221
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID334587Cytotoxicity against human primary soft tissue sarcoma cells after overnight incubation by Alamar blue assay2002Journal of natural products, May, Volume: 65, Issue:5
14'-Hydroxymytoxin B and 16-hydroxyroridin E, two new cytotoxic trichothecenes from Myrothecium roridum.
AID359205Cytotoxicity against mouse L1210 cells after 72 hrs by WST8 assay2001Journal of natural products, Mar, Volume: 64, Issue:3
A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau.
AID354844Antifungal activity against Ascobolus furfuraceus NRRL 6460 assessed as reduction in radical growth at 200 ug/disk by centerpoint inoculation disk assay1996Journal of natural products, Aug, Volume: 59, Issue:8
Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata.
AID359204Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay2001Journal of natural products, Mar, Volume: 64, Issue:3
A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau.
AID619753Cytotoxicity against human A549 cells after 72 hrs2011Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.
AID1594685Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay2019Journal of natural products, 06-28, Volume: 82, Issue:6
Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.
AID1573709Cytotoxicity against human HCC70 cells assessed as growth inhibition after 72 hrs by SRB assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.
AID1594686Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay2019Journal of natural products, 06-28, Volume: 82, Issue:6
Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.
AID1573711Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 72 hrs by SRB assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.
AID354845Antifungal activity against Candida albicans ATCC 14053 at 200 ug/disk1996Journal of natural products, Aug, Volume: 59, Issue:8
Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata.
AID378708Cytotoxicity against human KB cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID354843Antifungal activity against Sordaria fimicola NRRL 6459 assessed as reduction in radical growth at 200 ug/disk by centerpoint inoculation disk assay1996Journal of natural products, Aug, Volume: 59, Issue:8
Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata.
AID378710Cytotoxicity against human BC1 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID378712Cytotoxicity against african green monkey Vero cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID1573708Cytotoxicity against human BT549 cells assessed as growth inhibition after 72 hrs by SRB assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.
AID378707Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID1573710Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (22.22)18.7374
1990's5 (27.78)18.2507
2000's4 (22.22)29.6817
2010's5 (27.78)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.20 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index31.18 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sk&f-38393
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.. 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.. SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393		2.0610benzazepine;
catechols;
secondary amino compound
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0610aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.		2.0610organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.2110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
vanoxerine
vanoxerine: structure given in first source. vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.		2.0610ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor
patulin
Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.. patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.		1.9810furopyran;
gamma-lactone;
lactol		antimicrobial agent;
Aspergillus metabolite;
carcinogenic agent;
mutagen;
mycotoxin;
Penicillium metabolite
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		1.9810amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		1.9810antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
ergotamine
Ergotamine: A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.. ergotamine : A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.		2.0610peptide ergot alkaloidalpha-adrenergic agonist;
mycotoxin;
non-narcotic analgesic;
oxytocic;
serotonergic agonist;
vasoconstrictor agent
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.1710catechinantioxidant;
plant metabolite
monolaurin
monolaurin: RN given refers to cpd with unspecified monolaurin locant. 1-monolauroylglycerol : A 1-monoglyceride with dodecanoyl (lauroyl) as the acyl group.. rac-1-monolauroylglycerol : A rac-1-monoacylglycerol comprising equal amounts of 1-lauroyl-sn-glycerol and 3-lauroyl-sn-glycerol		2.17101-monoglyceride;
dodecanoate ester;
rac-1-monoacylglycerol
etoposide
[no description available]		2.2110beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		1.9910D-glucopyranoseepitope;
mouse metabolite
verrucarol
[no description available]		1.9610
satratoxin g
[no description available]		2.6530
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		2.0610
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		1.98103,5-dihydroxy-3-methylpentanoic acid
sesquiterpenes
[no description available]		3.9840
muconomycin a
verrucarin A : A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.		4.4970epoxide;
macrolide antibiotic;
macrotriolide;
organic heterotetracyclic compound;
trichothecene
meridianin a
meridianin A: structure in first source		2.0610
roridin a
roridin A: see also records for roridin D, E & J		2.7130
verrucarin j
[no description available]		4.3360trichothecene
satratoxin h
satratoxin H: toxic metabolite of Stachybotrys atra; see also record for satratoxin G; structure		2.8940trichothecene
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		0210
Sarcoma, Epithelioid
[description not available]		02.0110
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.		02.0110
Plant Poisoning
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.		01.9910
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