Compounds > verrucarin j
Page last updated: 2024-11-07

verrucarin j

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID12444784
CHEMBL ID507752
CHEBI ID184115
SCHEMBL ID258631
MeSH IDM0108615

Synonyms (17)

Synonym
verrucarin j
verrucarin a, 2',3'-didehydro-2'-deoxy-, (2'e)-
ai3-29711
verrucarin j, stereoisomer
2',3'-didehydro-2'-deoxyverrucarin a
muconomycin b
CHEMBL507752
CHEBI:184115
(1r,3r,8r,12e,18e,20z,24r,25s,26s)-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,12,18,20-tetraene-26,2'-oxirane]-11,17,22-trione
62ubu5q68g ,
unii-62ubu5q68g
SCHEMBL258631
verrucarin j [mi]
CS-0255891
verrucrin j
Q27263516
HY-N10113

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Trichothecene mycotoxins, toxic natural products of fungi from the family Hypocreaceae, are potent inhibitors of protein synthesis."( 3D QSAR study of the toxicity of trichothecene mycotoxins.
Lin, A; Rodarte, CB; Steinmetz, WE, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
trichotheceneAny one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID153613In vivo activity against P388 mouse leukemia at a dose of 0.8 mg/kg1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J.
AID120836Antileukemic activity in vivo against P-388 mouse leukemia(PS activity) and the T/C value was reported1980Journal of medicinal chemistry, Sep, Volume: 23, Issue:9
Antileukemic compounds derived from the chemical modification of macrocyclic trichothecenes. 1. Derivatives of verrucarin A.
AID467616Antitumor activity against human leukemia cells xenografted in mouse assessed as logarithm of extension of mouse life span relative to untreated control2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
3D QSAR study of the toxicity of trichothecene mycotoxins.
AID378707Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID467614Antitumor activity against human leukemia cells xenografted in mouse assessed as extension of mouse life span relative to untreated control2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
3D QSAR study of the toxicity of trichothecene mycotoxins.
AID378712Cytotoxicity against african green monkey Vero cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID378710Cytotoxicity against human BC1 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
AID112128Antileukemic activity in vivo against P-388 mouse leukemia cell expressed as Dose1980Journal of medicinal chemistry, Sep, Volume: 23, Issue:9
Antileukemic compounds derived from the chemical modification of macrocyclic trichothecenes. 1. Derivatives of verrucarin A.
AID359204Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay2001Journal of natural products, Mar, Volume: 64, Issue:3
A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau.
AID359205Cytotoxicity against mouse L1210 cells after 72 hrs by WST8 assay2001Journal of natural products, Mar, Volume: 64, Issue:3
A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau.
AID378708Cytotoxicity against human KB cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (53.33)18.7374
1990's1 (6.67)18.2507
2000's3 (20.00)29.6817
2010's2 (13.33)24.3611
2020's1 (6.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
deoxynivalenol
deoxynivalenol : A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.		2.0510cyclic ketone;
enone;
primary alcohol;
secondary alpha-hydroxy ketone;
trichothecene;
triol		mycotoxin
satratoxin g
[no description available]		2.3720
sesquiterpenes
[no description available]		4.1650
t-2 toxin
[no description available]		2.0510acetate ester;
organic heterotetracyclic compound;
trichothecene		apoptosis inducer;
cardiotoxic agent;
DNA synthesis inhibitor;
environmental contaminant;
fungal metabolite;
mycotoxin;
neurotoxin
muconomycin a
verrucarin A : A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.		4.4770epoxide;
macrolide antibiotic;
macrotriolide;
organic heterotetracyclic compound;
trichothecene
HT-2 toxin
[no description available]		2.0510acetate ester;
organic heterotetracyclic compound;
trichothecene		apoptosis inducer;
fungal metabolite
15-acetyldeoxynivalenol
15-acetyldeoxynivalenol : A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.		2.0510trichotheceneepitope;
mycotoxin
roridin a
roridin A: see also records for roridin D, E & J		2.3820
roridin e
roridin E: RN given refers to (2'E,7'R(R))-isomer; see also roridin J: 74042-83-6		4.3360
satratoxin h
satratoxin H: toxic metabolite of Stachybotrys atra; see also record for satratoxin G; structure		2.6630trichothecene
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Leukemia
[description not available]		01.9610
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.3620
Leukemia L 1210
[description not available]		0210
Cancer of Colon
[description not available]		02.1710
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1710
Cancer of Lung
[description not available]		02.2110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.2110