bde 183 profile

2,2',3,4,4',5',6-heptabromodiphenyl ether: a polybrominated diphenyl ether compound [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	15509899
CHEMBL ID	219178
CHEBI ID	81537
SCHEMBL ID	14938742
MeSH ID	M0472858

Synonym
207122-16-5
2,2',3,4,4',5',6-heptabde
2,2',3,4,4',5',6-heptabromodiphenyl ether
pbde 183
bde 183
bde-183
benzene, 1,2,3,5-tetrabromo-4-(2,4,5-tribromophenoxy)-
2,2',3,4,4',5',6-heptabromodiphenylether
chebi:81537 ,
CHEMBL219178
1,2,3,5-tetrabromo-4-(2,4,5-tribromophenoxy)-benzene
C18140
unii-6m82n9dxai
6m82n9dxai ,
DTXSID8052693
SCHEMBL14938742
ILPSCQCLBHQUEM-UHFFFAOYSA-N
1,2,3,5-tetrabromo-4-(2,4,5-tribromophenoxy)benzene
J-013540
Q27155453
pbde no. 183
pbde 183 50 microg/ml in nonane

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
"The toxic effects of two brominated diphenyl ethers (BDE), BDE-47, and BDE-183, on a benthic oligochaete tubificid, Monopylephorus limosus were studied under laboratory conditions."	( Toxic effects of two brominated flame retardants BDE-47 and BDE-183 on the survival and protein expression of the tubificid Monopylephorus limosus. Chiu, KH; Huang, HW; Lin, CR; Liu, LL; Shiea, J, 2012)	0.38

Bioavailability

Excerpt	Reference	Relevance
" The main reason for their concentration decrease or absence in biota may be due to low bioavailability potential or due to biotransformation processes."	( Congener distribution of polybrominated diphenyl ethers in feral carp (Cyprinus carpio) from the Llobregat River, Spain. Barceló, D; Eljarrat, E; Labandeira, A, 2007)	0.34

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Class	Description
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
organobromine compound	A compound containing at least one carbon-bromine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID274424	Displacement of androgen fluormone from androgen receptor at 100 uM	2006	Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25	Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist.
AID274429	Activity against human androgen receptor expressed in HepG2 cells assessed as renilla reporter gene activation in presence of 1 nM DHT at 1 uM after 40 hrs	2006	Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25	Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (28.57)	29.6817
2010's	19 (67.86)	24.3611
2020's	1 (3.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.57%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (96.43%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2,4,6-tribromophenol [no description available]	2.03	1	bromophenol	environmental contaminant; fungicide; marine metabolite
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	2.51	2	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
tetrabromobisphenol a tetrabromobisphenol A: a brominated flame retardant. 3,3',5,5'-tetrabromobisphenol A : A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.	2.03	1	brominated flame retardant; bromobisphenol
hexabromobenzene [no description available]	2.03	1
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	2.03	1	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
decabromobiphenyl ether decabromobiphenyl ether: a flame retardant. decabromodiphenyl ether : A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.	4.12	14	polybromodiphenyl ether	neurotoxin
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane: a flame retardant and androgen receptor agonist; structure in first source	2.03	1
bromine Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.	2.46	2	diatomic bromine
bde 206 2,2',3,3',4,4',5,5',6-nonabromodiphenyl ether: structure in first source	2.52	2
2,2',4,4'-tetrabromodiphenyl ether [no description available]	3.88	11	aromatic ether; organobromine compound
beta-bromostyrene [no description available]	2.03	1
beta-escin [no description available]	2.1	1
decabromodiphenyl ethane decabromodiphenyl ethane: structure in first source	2.03	1
bde 207 2,2',3,3',4,4',5,6,6'-nonabromodiphenyl ether: structure in first source	2.54	2
bde 197 2,2',3,3',4,4',6,6'-octabromodiphenyl ether: a component of DE-79, a technical octabromo diphenyl ether mixture	2.54	2
tribromodiphenyl ether 28 4-bromophenyl 2,4-dibromophenyl ether : A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, and 4' positions have been replaced by bromines.	3.49	7	polybromodiphenyl ether
bde 208 2,2',3,3',4,5,5',6,6'-nonabromodiphenyl ether: structure in first source	2.1	1
2,2',4,5'-tetrabromodiphenyl ether [no description available]	2.15	1	aromatic ether; organobromine compound
hexabromodiphenyl ether 154 2,2',4,4',5,6'-hexabromodiphenyl ether: structure in first source	2.79	3	aromatic ether; organobromine compound

bde 183

Description

Cross-References

Synonyms (22)

Research Excerpts

Toxicity

Bioavailability

Drug Classes (2)

Bioassays (2)

Research

Studies (28)

Market Indicators

Research Demand Index: 19.09

Study Types

bde 183

Description

Cross-References

Synonyms (22)

Research Excerpts

Toxicity

Bioavailability

Drug Classes (2)

Bioassays (2)

Research

Studies (28)

Market Indicators

Research Demand Index: 19.09

Study Types

Related Drugs (19)

Related Conditions (1)