Compounds > dechlorane 602
Page last updated: 2024-11-06

dechlorane 602

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dechlorane 602 is a persistent organic pollutant (POP) that belongs to the chlorinated camphene family. It was primarily used as a flame retardant in various materials such as plastics, textiles, and electronics. Dechlorane 602 is synthesized through a multi-step process involving the chlorination of camphene, followed by a series of reactions to introduce the desired chlorine atoms. This compound has been found to be highly persistent in the environment, with a long half-life and a tendency to accumulate in biota. Studies have indicated that Dechlorane 602 can bioaccumulate in organisms, leading to potential health risks, including endocrine disruption, developmental effects, and cancer. The persistence and potential toxicity of Dechlorane 602 have raised significant environmental concerns. Dechlorane 602 has been subject to international regulation under the Stockholm Convention on Persistent Organic Pollutants, leading to restrictions on its production and use. The compound's persistence, bioaccumulation, and potential toxicity make it a target of ongoing research efforts aimed at understanding its environmental fate, exposure pathways, and potential health impacts. Researchers are actively studying the environmental fate of Dechlorane 602 to assess its persistence, transport, and degradation in different environmental compartments. Furthermore, research aims to investigate the bioaccumulation of Dechlorane 602 in various organisms and determine its potential toxic effects on different species. The comprehensive understanding of the compound's behavior and impacts is crucial for effective environmental management and mitigation strategies.'

dechlorane 602: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID35733
SCHEMBL ID10453125
MeSH IDM0555834

Synonyms (12)

Synonym
dechlorane 602
FT-0665543
1,4:6,9-dimethanodibenzofuran, 1,2,3,4,6,7,8,9,10,10,11,11-dodecachloro-1,4,4a,5a,6,9,9a,9b-octahydro-
einecs 250-472-9
1,2,3,4,6,7,8,9,10,10,11,11-dodecachloro-1,4,4a,5a,6,9,9a,9b-octahydro-1,4:6,9-dimethanodibenzofuran
ai3-27887
ai 3-27887
31107-44-5
SCHEMBL10453125
AKOS030239793
J-018242
1,4,5,6,7,11,12,13,14,14,15,15-dodecachloro-9-oxapentacyclo[9.2.1.14,7.02,10.03,8]pentadeca-5,12-diene

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Significant alterations of immune and neurotransmitter-related metabolites (tyrosine, tryptophan, kynurenic acid, and xanthurenic acid) suggest that the toxic effects of Dec 602 may contribute to its interactions with the immune and neuronal systems."( Metabolic profiling study on potential toxicity in male mice treated with Dechlorane 602 using UHPLC-ESI-IT-TOF-MS.
Chen, Y; Fu, H; Guo, Z; Ji, F; Ma, C; Tao, W; Tian, J; Xie, HQ; Xu, H; Xu, L; Xu, T; Yang, J; Yin, X; Zhang, S; Zhang, W; Zhao, B; Zhou, Z, 2019)		0.74

Bioavailability

ExcerptReferenceRelevance
" Thus, attention should be given to these highly bioavailable flame retardants in future environmental biomonitoring and risk assessments in a post-PBDE era."( Halogenated flame retardants in bobcats from the midwestern United States.
Boyles, E; Chen, D; Nielsen, CK; Reiner, EJ; Shen, L; Tan, H; Wu, Y, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's26 (92.86)24.3611
2020's2 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.35 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index4.53 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (96.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hexachlorocyclohexane
Lindane: An organochlorine insecticide made up of greater than 99% gamma-Hexachlorocyclohexane. It has been used as a pediculicide and scabicide, and shown to cause cancer.. beta-hexachlorocyclohexane : The beta-isomer of hexachlorocyclohexane.		2.1110chlorocyclohexane
toluene
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.		2.1510methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
endosulfan
Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61). endosulfan : A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.		2.1110cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
chlordan
Chlordan: A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)		2.0610cyclodiene organochlorine insecticideGABA-gated chloride channel antagonist;
persistent organic pollutant
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		2.1110benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
hexabromobenzene
[no description available]		2.1110
2-chlorotoluene
2-chlorotoluene: RN given refers to parent cpd		2.1510
triphenyl phosphate
triphenyl phosphate: structure. triphenyl phosphate : An aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol.		2.1510aryl phosphateflame retardant;
plasticiser
tris(chloroethyl)phosphate
tris(chloroethyl)phosphate: has gonadotoxic effects. tris(2-chloroethyl) phosphate : A trialkyl phosphate that is the tris(2-chloroethyl) ester of phosphoric acid.		2.1510organochlorine compound;
trialkyl phosphate
decabromobiphenyl ether
decabromobiphenyl ether: a flame retardant. decabromodiphenyl ether : A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.		2.5220polybromodiphenyl etherneurotoxin
mirex
Mirex: An organochlorine insecticide that is carcinogenic.		2.9940chlorocarbon;
organochlorine insecticide		persistent organic pollutant
dechlorane plus
dechlorane plus: a flame retardant; structure in first source		10.4170
tributyl phosphate
tributyl phosphate: a detergent. tributyl phosphate : A trialkyl phosphate that is the tributyl ester of phosphoric acid.		2.1510trialkyl phosphate
2,2',4,4'-tetrabromodiphenyl ether
[no description available]		2.5220aromatic ether;
organobromine compound
2,3-dibromopropyl-2,4,6-tribromophenyl ether
2,3-dibromopropyl-2,4,6-tribromophenyl ether: brominated flame retardant; structure in first source		2.1110
dechlorane 604
dechlorane 604: structure in first source		5.39170
dechlorane 603
dechlorane 603: structure in first source		5.39170
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.7620
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.7620
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.110