1,2-bis(2,4,6-tribromophenoxy)ethane is a brominated flame retardant that has been widely used in various consumer products, such as plastics, textiles, and electronics. It is a white crystalline solid with a high molecular weight. The synthesis of 1,2-bis(2,4,6-tribromophenoxy)ethane typically involves the reaction of 2,4,6-tribromophenol with 1,2-dibromoethane in the presence of a base, such as potassium hydroxide. The compound is known to be persistent in the environment and can accumulate in the food chain. Studies have shown that 1,2-bis(2,4,6-tribromophenoxy)ethane can have adverse effects on human health, including endocrine disruption, developmental toxicity, and neurotoxicity. Due to its environmental persistence, bioaccumulation, and potential toxicity, 1,2-bis(2,4,6-tribromophenoxy)ethane has been the subject of extensive research and is often considered a compound of concern. It has been studied extensively due to its presence in the environment, its potential for bioaccumulation, and its potential toxicity to wildlife and humans. Researchers are interested in understanding the fate and transport of this compound in the environment, as well as its potential health effects. '
1,2-bis(2,4,6-tribromophenoxy)ethane: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 37840 |
| SCHEMBL ID | 94118 |
| MeSH ID | M0216226 |
| Synonym |
|---|
| einecs 253-692-3 |
| ccris 4752 |
| benzene, 1,1'-(1,2-ethanediylbis(oxy))bis(2,4,6-tribromo- |
| ff 680 |
| hsdb 6099 |
| 1,1'-(ethane-1,2-diylbisoxy)bis(2,4,6-tribromobenzene) |
| ethane, 1,2-bis(2,4,6-tribromophenoxy)- |
| 1,2-bis(2,4,6-tribromophenoxy)ethane |
| 1,1'-(1,2-ethanediylbis(oxy))bis(2,4,6-tribromobenzene) |
| firemaster ff 680 |
| benzene, 1,1'-[1,2-ethanediylbis(oxy)]bis[2,4,6-tribromo- |
| firemaster 680 |
| 1,1'-[ethane-1,2-diylbis(oxy)]bis(2,4,6-tribromobenzene) |
| 37853-59-1 |
| bis(tribromophenoxy)ethane |
| 1,3,5-tribromo-2-[2-(2,4,6-tribromophenoxy)ethoxy]benzene |
| 1,2-bis(2,4,6-tribromo-phenoxy)ethane |
| 34i00d6rnm , |
| bis-1,2-(2,4,6-tribromophenoxy)ethane |
| btbpe |
| unii-34i00d6rnm |
| FT-0648816 |
| SCHEMBL94118 |
| AKOS022173302 |
| 1,2-bis(2,4,6-tribromophenoxy)ethane [hsdb] |
| W-106506 |
| YATIGPZCMOYEGE-UHFFFAOYSA-N |
| DTXSID1024627 |
| 1,2-bis(2,4,6-tribromophenoxy)ethane, analytical standard |
| 1,1-(1,2-ethanediylbis(oxy))bis(2,4,6-tribromobenzene) |
| mfcd00071811 |
| AS-12816 |
| Q16830216 |
| D83362 |
| CS-0158312 |
| 1,2-bis(2,4,6-tribromophenoxy)ethane (btbpe) |
| bis (tribromophenoxy) ethane |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The data indicate that FF-680 was very poorly absorbed from the gastrointestinal tract." | ( Disposition of the flame retardant 1,2-bis(2,4,6-tribromophenoxy)ethane in rats following administration in the diet. Chadwick, M; Ghanayem, BI; Markham, PM; Nomeir, AA, ) | 0.41 |
| " However, contaminant bioavailability is influenced by the organisms' ecology (i." | ( In situ accumulation of HBCD, PBDEs, and several alternative flame-retardants in the bivalve (Corbicula fluminea) and gastropod (Elimia proxima). Ciparis, S; Hale, RC; Harvey, E; La Guardia, MJ; Mainor, TM, 2012) | 0.38 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " At 4 days after the start of administration of the dosed diet for 1 day, no radioactivity was detected in any tissue analyzed, except adipose tissue, skin, and thymus, in which trace concentrations of radioactivity were detected in some animals." | ( Disposition of the flame retardant 1,2-bis(2,4,6-tribromophenoxy)ethane in rats following administration in the diet. Chadwick, M; Ghanayem, BI; Markham, PM; Nomeir, AA, ) | 0.41 |
| " Both compounds were detected in fish carcasses at 76% and 2% of the daily dosage of BTBPE and EH-TBB, respectively, indicating accumulation of BTBPE and by contrast extensive depuration/metabolism of EH-TBB." | ( Effects of food-borne exposure of juvenile rainbow trout (Oncorhynchus mykiss) to emerging brominated flame retardants 1,2-bis(2,4,6-tribromophenoxy)ethane and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate. Douville, M; Giraudo, M; Houde, M; Letcher, RJ, 2017) | 0.66 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 25 (78.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.12) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.03%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (96.97%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||