Compounds > 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
Page last updated: 2024-12-10

1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

**1,1-Bis(3'-indolyl)-1-(4-hydroxyphenyl)methane** is a synthetic compound that has been shown to have promising biological activity, specifically in the context of neuroprotection and cancer therapy.

**Structure and Properties:**

* It is a triarylmethane derivative, consisting of two indole rings attached to a central carbon atom that is also linked to a 4-hydroxyphenyl group.
* The presence of the indole ring system is significant, as indole derivatives are often found in natural products and have a wide range of biological activities.
* The hydroxyl group on the phenyl ring contributes to the compound's potential for interactions with biological targets.

**Importance in Research:**

**1. Neuroprotection:**
* Studies have indicated that 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane possesses neuroprotective properties.
* It has been shown to protect neurons from damage caused by oxidative stress, glutamate excitotoxicity, and amyloid-beta aggregation, all factors implicated in neurodegenerative diseases like Alzheimer's disease and Parkinson's disease.

**2. Cancer Therapy:**
* The compound exhibits anticancer activity against various cancer cell lines, including leukemia, breast cancer, and colon cancer.
* Its mechanism of action in cancer therapy is believed to involve inhibition of cell proliferation, induction of apoptosis (programmed cell death), and modulation of signaling pathways involved in cancer development.

**3. Other Biological Activities:**
* 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane has also been reported to have anti-inflammatory, antioxidant, and anti-angiogenic activities.
* Its potential as a therapeutic agent for a range of diseases is being investigated.

**Current Research and Future Prospects:**

* Ongoing research focuses on understanding the precise mechanisms of action of this compound and its potential for clinical development.
* Preclinical studies are evaluating its efficacy and safety in animal models of disease.
* Further optimization of its structure and delivery methods is being investigated to improve its therapeutic potential.

**Conclusion:**

1,1-Bis(3'-indolyl)-1-(4-hydroxyphenyl)methane is a promising compound with significant potential in neuroprotection, cancer therapy, and other therapeutic areas. Its unique structural features and biological activities make it an attractive target for further research and development.

Cross-References

ID SourceID
PubMed CID2940609
CHEMBL ID1939127
SCHEMBL ID3495495
MeSH IDM0550420

Synonyms (26)

Synonym
AKOS000358286
4-[bis(1h-indol-3-yl)methyl]phenol
STK521918
4-(di-1h-indol-3-ylmethyl)phenol
CHEMBL1939127
4-(di(1h-indol-3-yl)methyl)phenol
151358-47-3
S6799
AB01248912-03
SCHEMBL3495495
dim-c-pphoh
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
phenol, 4-(di-1h-indol-3-ylmethyl)-
dim-c-pphoh(cdim8)
NCGC00340423-01
BCP28949
F21373
c-dim 8
c-dim8
mfcd03723253
DS-18778
CS-0042518
HY-112055
cdim8
A926361

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Each compound conferred significant protection against progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), even when given after 7 days of dosing with MPTPp."( Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.
De Miranda, BR; Hammond, SL; Miller, JA; Popichak, KA; Safe, S; Tjalkens, RB, 2015)		0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
G-protein coupled receptor 84Homo sapiens (human)EC50 (µMol)10.00000.08903.868710.0000AID1447407; AID1447408
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
biological_processG-protein coupled receptor 84Homo sapiens (human)
neuropeptide signaling pathwayG-protein coupled receptor 84Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
urotensin II receptor activityG-protein coupled receptor 84Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
plasma membraneG-protein coupled receptor 84Homo sapiens (human)
specific granule membraneG-protein coupled receptor 84Homo sapiens (human)
tertiary granule membraneG-protein coupled receptor 84Homo sapiens (human)
receptor complexG-protein coupled receptor 84Homo sapiens (human)
plasma membraneG-protein coupled receptor 84Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (49)

Assay IDTitleYearJournalArticle
AID641509Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G1 phase at 2 uM after 24 hrs by flow cytometry (Rvb = 46%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641517Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G1 phase at 8 uM after 24 hrs by flow cytometry (Rvb = 65.58%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID1447406Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation at 10 uM after 15 mins in presence of [3H]-cAMP by radiometric assay relative to decanoic acid
AID641501Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G1 phase at 4 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641508Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G0 phase at 2 uM after 24 hrs by flow cytometry (Rvb = 2.9%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641504Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G0 phase at 8 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641497Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G1 phase at 2 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641510Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in S phase at 2 uM after 24 hrs by flow cytometry (Rvb = 14.87%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID1447425Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase complementation assay
AID641570Inhibition of HDAC1 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641502Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in S phase at 4 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641496Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G0 phase at 2 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641571Inhibition of HDAC2 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744541Antifungal activity against Aspergillus fumigatus ATCC 204305 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID641499Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2/M phase at 2 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744542Antibacterial activity against Mycobacterium intracellulare ATCC 23068 by alamar blue assay2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID641511Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2/M phase at 2 uM after 24 hrs by flow cytometry (Rvb = 36.23%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641576Induction of apoptosis in human MCF7 cells assessed as caspase-7 activation at 8 uM after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641569Inhibition of tubulin polymerization in human MCF7 cells at 2 uM after 24 hrs by FITC-conjugated immunostaining assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744540Antifungal activity against Candida albicans ATCC 90028 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID1447427Antagonist activity at human FFAR4 expressed in CHO cells assessed as inhibition of TUG-89-induced beta-arrestin recruitment at 10 uM preincubated for 30 mins followed by TUG-89 addition measured after 90 mins by beta-galactosidase complementation assay
AID1447409Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase complementation assay relative to embelin
AID641516Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G0 phase at 8 uM after 24 hrs by flow cytometry (Rvb = 3.22%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744548Antileishmanial activity against promastigote of Leishmania donovani after 72 hrs by alamar blue assay2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID641512Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G0 phase at 4 uM after 24 hrs by flow cytometry (Rvb = 3.22%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744544Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID744543Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID1447413Antagonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of decanoic acid-induced receptor activation at 10 uM
AID641572Inhibition of HDAC3 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641506Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in S phase at 8 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744547Antileishmanial activity against axenic amastigote of Leishmania donovani after 72 hrs by alamar blue assay2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID641503Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2/M phase at 4 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744539Antifungal activity against Cryptococcus neoformans ATCC 90113 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID1447407Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
AID641500Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G0 phase at 4 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641514Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in S phase at 4 uM after 24 hrs by flow cytometry (Rvb = 5.55%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641498Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in S phase at 2 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641495Anticancer activity against human MCF7 cells assessed as cell death at 2 uM after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641507Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2/M phase at 8 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641519Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2/M phase at 8 uM after 24 hrs by flow cytometry (Rvb = 25.65%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641573Inhibition of HDAC8 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641575Induction of apoptosis in human MCF7 cells assessed as PARP-cleavage at 8 uM after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID744545Cytotoxicity against african green monkey Vero cells up to 4.6 ug/ml after 48 hrs by neutral red assay2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID1447424Agonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as induction of intracellular calcium level at 10 uM measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay
AID641513Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G1 phase at 4 uM after 24 hrs by flow cytometry (Rvb = 65.58%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID1447408Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
AID641518Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in S phase at 8 uM after 24 hrs by flow cytometry (Rvb = 5.55%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641505Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G1 phase at 8 uM after 24 hrs by flow cytometry relative to untreated control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
AID641515Induction of cell cycle arrest in human MCF7 cells assessed as accumulation of cells in G2/M phase at 4 uM after 24 hrs by flow cytometry (Rvb = 25.65%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's17 (94.44)24.3611
2020's1 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.14 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index6.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (94.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0810aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
metformin
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.		2.1710guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0810aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		2.0810secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
hamacanthine a
hamacanthine A: a dihydropyrazinonediylbis(indole) alkaloid from deep-water marine sponge Hamacantha sp.; structure in first source. hamacanthin A : A member of the class of pyrazinones that is 5,6-dihydropyrazin-2(1H)-one substituted at positions 3 and 6 by 6-bromo-1H-indol-3-yl groups. It is an antifungal drug isolated from deep water marine sponge Hamacantha sp.		2.0810
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0810antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
cytosporone b
cytosporone B: a Nur77 agonist; structure in first source		3.1610aromatic ketone
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Black Fever
[description not available]		02.0810
Leishmaniasis, Visceral
A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.		02.0810
Rhabdomyosarcoma
A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)		02.5720
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.6320
Endometrioma
An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.		02.2510
Endometriosis
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.		02.2510
Cancer of Colon
[description not available]		02.5220
Cancer of Pancreas
[description not available]		02.7830
Colonic Neoplasms
Tumors or cancer of the COLON.		02.5220
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.7830
Breast Cancer
[description not available]		02.8330
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.8330
Cancer of Lung
[description not available]		02.4820
Lung Neoplasms
Tumors or cancer of the LUNG.		02.4820
Idiopathic Parkinson Disease
[description not available]		02.1110
MPTP Neurotoxicity Syndrome
[description not available]		02.1110
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)		02.1110
Benign Neoplasms
[description not available]		02.9810
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.9810
Carcinoma, Non-Small Cell Lung
[description not available]		02.0710
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.0710