fluensulfone: a nematicide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
fluensulfone : A member of the class of 1,3-thiazoles carrying 3,4,4-trifluorobut-3-ene-1-sulfonyl and chloro substituents at positions 2 and 5 respectively. A nematicide that is effective against a number of plant parasitic nematodes in a range of agricultural and horticultural crops. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 11534927 |
| CHEBI ID | 131597 |
| SCHEMBL ID | 174908 |
| MeSH ID | M0573490 |
| Synonym |
|---|
| 5-chloro-2-(3,4,4-trifluorobut-3-enylsulfonyl)-1,3-thiazole |
| FT-0668570 |
| 5-chloro-1,3-thiazol-2-yl 3,4,4-trifluorobut-3-en-1-yl sulfone |
| 5-chloro-2-(3,4,4-trifluorobut-3-en-1-ylsulfonyl)-1,3-thiazole |
| fluensulfone |
| 318290-98-1 |
| 5-chloro-2-(3,4,4-trifluorobut-3-ene-1-sulfonyl)-1,3-thiazole |
| CHEBI:131597 |
| fluensulfone [iso] |
| unii-i7v6200877 |
| i7v6200877 , |
| 5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)sulfonyl]thiazole |
| 5-chloro-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-1,3-thiazole |
| SCHEMBL174908 |
| 5-chloro-2-((3,4,4-trifluoro-3-buten-1-yl)sulfonyl)thiazole |
| DTXSID1058054 |
| AC-35258 |
| CS-7957 |
| HY-107771 |
| mcw-2 |
| thiazole, 5-chloro-2-[(3,4,4-trifluoro-3-butenyl)sulfonyl]- |
| AKOS027439950 |
| mfcd29047086 |
| thiazole, 5-chloro-2-[(3,4,4-trifluoro-3-butenyl)sulfonyl]- (9ci); 5-chloro-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-1,3-thiazole; fluensulfone; mcw 2; thiazole, 5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)sulfonyl]- |
| fluensulfone 100 microg/ml in acetonitrile |
| BCP16864 |
| mcw-2;mcw 2;mcw2 |
| 5-chloro-2-((3,4,4-trifluorobut-3-en-1-yl)sulfonyl)thiazole |
| AS-49857 |
| Q27225210 |
| N11430 |
| A902682 |
| xsnmwapkhugzgq-uhfffaoysa-n |
| thiazole, 5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)sulfonyl]- |
Fluensulfone is a fluoroalkenyl chemical with activity against multiple genera of plant-parasitic nematodes. It is a potent inhibitor of hatching and impacts on the viability of the J2 s emerging from the cysts.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Fluensulfone has shown an increased incidence of lung adenomas in mice, but not in rats, at high doses." | ( Relationship of metabolism and cell proliferation to the mode of action of fluensulfone-induced mouse lung tumors: analysis of their human relevance using the IPCS framework. Banas, DA; Cohen, SM; Gordon, EB; Jaeger, M; Strupp, C; Weber, K, 2012) | 1.33 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The fluensulfone treatments at the full rate had more consistent effects than the lower rates, and there were no greater effects for the treatments higher than this full rate." | ( Field evaluation of the nematicide fluensulfone for control of the potato cyst nematode Globodera pallida. Back, MA; Grove, IG; Norshie, PM, 2016) | 1.19 |
| Role | Description |
|---|---|
| nematicide | A substance used to destroy pests of the phylum Nematoda (roundworms). |
| agrochemical | An agrochemical is a substance that is used in agriculture or horticulture. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| 1,3-thiazoles | |
| organochlorine pesticide | Any organochlorine compound that has been used as a pesticide. |
| sulfone | An organosulfur compound having the structure RS(=O)2R (R =/= H). |
| organofluorine pesticide | |
| olefinic compound | Any organic molecular entity that contains at least one C=C bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (32.79) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (5.56%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (94.44%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||