| Assay ID | Title | Year | Journal | Article |
|---|
| AID35781 | Inhibitory activity against Alpha-2 adrenergic receptor using [3H]RX-821002 at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID6050 | Antagonistic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch reflex in rats at 60 (ug/kg), evaluated as percent inhibition of bradycardia | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID140948 | Inhibitory activity against Muscarinic acetylcholine receptor M2 using [3H]NMS at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID39487 | Inhibitory activity against Angiotensin II receptor using [3H]Angiotensin II at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID93083 | Displacement of [3H]insulin from Insulin receptor at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID5683 | Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID152092 | Inhibitory activity against Opioid receptor mu 1 using [3H]DAMGO at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID50528 | Inhibitory activity against Cholecystokinin type A receptor using [3H]L-364718 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID4298 | Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID36320 | Inhibitory activity against Alpha-1 adrenergic receptor using [3H]-prazosin at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID148738 | Inhibitory activity against Opioid receptor kappa 1 using [3H]U-69593 at 10e-7 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID71406 | Inhibitory activity against Gamma-aminobutyric acid type B receptor using [3H]GABA at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID64131 | In vitro displacement from Dopamine receptor D2 | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID5153 | Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID6317 | Binding affinity towards 5-hydroxytryptamine 3 receptor | 2001 | Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4
| First tricyclic oximino derivatives as 5-HT3 ligands. |
| AID161278 | Inhibition of [3H]apamin binding to Potassium channel at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID148737 | Inhibitory activity against Opioid receptor kappa 1 using [3H]U-69593 at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID6046 | Agonistic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch Reflex in rats at 60 (ug/kg), evaluated as change in heart rate | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID215074 | Inhibitory activity against TNF using [125]TNF at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID6357 | Binding affinity towards 5-hydroxytryptamine 3 receptor | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID3459 | Binding affinity for 5-hydroxytryptamine 1A receptor | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID147814 | Inhibitory activity against Opioid receptor delta 1 using [3H]Cl-phe-DPDPE at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID141746 | Inhibitory activity against Muscarinic acetylcholine receptor M3 using [3H]NMS at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID51619 | Inhibitory activity against Cholecystokinin type B receptor using [3H]CCK-8 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID42991 | Inhibitory activity against Bradykinin receptor using [3H]bradykinin at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID64132 | In vitro displacement from Dopamine receptor D2 | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID4852 | Binding affinity for 5-hydroxytryptamine 1D receptor | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID41498 | Inhibitory activity against Beta-2 adrenergic receptor using [3H]CGP-12177 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID4299 | Binding affinity for 5-hydroxytryptamine 1B receptor | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID102659 | Inhibitory activity against Leukotriene B4 receptor using [3H]- LTB4 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID40992 | Inhibition of [3H]flunitrazepam binding to GABA-A central Benzodiazepine receptor at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID216931 | Inhibitory activity against VIP using [125]VIP at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID61836 | Inhibitory activity against Dopamine receptor D1 using [3H]SCH-23,390 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID212442 | Inhibitory activity against Thromboxane A2 using [3H]SG-29548 at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID146598 | Inhibitory activity against Neuropeptide Y receptor type 1 using [3H]-NPY at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID5154 | Binding affinity towards 5-hydroxytryptamine 2A receptor | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID3458 | Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID163313 | Inhibitory activity against Quisqualate receptor using [3H]AMPA at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID40993 | Inhibition of [3H]PK11195 binding to peripheral Benzodiazepine receptor at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID72450 | Inhibitory activity against Gamma-aminobutyric acid A (GABA-A) receptor using [3H]-muscimol at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID205294 | Inhibition of [3H]batrachotoxin binding to sodium channel at 10e-7 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID416527 | Displacement of [3H]granisetron form 5HT3 receptor in hybrid NG180-15 cells | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
| Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. |
| AID143461 | Inhibitory activity against NMDA using [3H]CGS-19,755 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID143660 | In vitro effective concentration against [14C]guanidinium uptake into NG 108-15 cells | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID4851 | Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID1855131 | Binding affinity to 5-HT3 receptor (unknown origin) assessed as inhibition constant | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors. |
| AID40547 | Inhibitory activity against Beta-1 adrenergic receptor using [3H]CGP-12177 at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID143659 | In Vitro 5-HT3 agonist activity on the [14C]guanidinium accumulation in NG 108-15 cells. | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID55236 | Inhibitory activity against Cysteinyl leukotriene D4 receptor using [3H]- LTD4 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID5685 | Binding affinity towards 5-hydroxytryptamine 2C receptor | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID416526 | Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum membrane | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
| Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. |
| AID205293 | Inhibition of [3H]batrachotoxin binding to sodium channel at 10e-5 M | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID183866 | In Vivo 5-HT3 agonist activity in the Von Bezold-Jarisch reflex decrease in heart rate in rats at 120 (ug/kg) dose. | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID141975 | Inhibitory activity against Muscarinic acetylcholine receptor M1 using [3H]pirenzepine at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID30477 | Inhibitory activity against Adenosine A1 receptor using [3H]DPCPX at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID210545 | Inhibitory activity against TRH using [3H]TRH at 10e-5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID91877 | Inhibitory activity against Interleukin 1d using [3H]IL-1-alpha at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID157595 | Inhibitory activity against Phencyclidine receptor using [3H]-TCP at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID183870 | In Vivo 5-HT3 antagonist activity in the Von Bezold-Jarisch reflex in rats at intravenous dose of 60 (ug/kg) | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID6355 | Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand | 1997 | Journal of medicinal chemistry, Jun-06, Volume: 40, Issue:12
| Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. |
| AID91468 | Inhibitory activity against Ionotropic glutamate receptor kainate using [3H]- Kainate at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID33914 | Inhibitory activity against Adenosine A2 receptor using [3H]CGS-21680 at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID6045 | Agonistic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch Reflex in rats at 120 (ug/kg), evaluated as change in heart rate | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| AID158052 | Inhibitory activity against Platelet activating factor receptor using [3H]PAF at 10e5 (M) | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |