| ID Source | ID |
|---|---|
| PubMed CID | 361510 |
| CHEMBL ID | 290914 |
| CHEBI ID | 93655 |
| SCHEMBL ID | 5073407 |
| Synonym |
|---|
| BRD-K94841585-001-03-6 |
| emodic acid |
| nsc624610 |
| nsc-624610 |
| 4,5,7-trihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid |
| 4,5,7-trihydroxy-9,10-dioxo-anthracene-2-carboxylic acid |
| DIVK1C_006880 |
| SDCCGMLS-0066762.P001 |
| SPECTRUM_000189 |
| SPECTRUM4_001974 |
| SPECTRUM5_000645 |
| ACON0_001437 |
| BSPBIO_002597 |
| ACON1_000410 |
| MEGXM0_000113 |
| MLS000876948 , |
| smr000440655 |
| NCGC00095847-01 |
| KBIO2_000669 |
| KBIO2_005805 |
| KBIO3_002097 |
| KBIO2_003237 |
| KBIO1_001824 |
| KBIOSS_000669 |
| KBIOGR_002473 |
| SPECTRUM2_000421 |
| SPECTRUM3_001129 |
| SPBIO_000402 |
| SPECPLUS_000784 |
| SPECTRUM1504060 |
| NCGC00095847-03 |
| NCGC00095847-02 |
| CHEMBL290914 |
| 4,5,7-trihydroxy-9,10-dioxoanthracene-2-carboxylic acid |
| 2-anthracenecarboxylicacid, 9,10-dihydro-4,5,7-trihydroxy-9,10-dioxo- |
| HMS2267O14 |
| CCG-38681 |
| 4,5,7- trihydroxy-2-carboxyanthraquinone |
| ZJXVNNSMRGTDBI-UHFFFAOYSA-N |
| SCHEMBL5073407 |
| 4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acid |
| 4,5,7-tris(oxidanyl)-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid |
| 4,5,7-trihydroxy-9,10-diketo-anthracene-2-carboxylic acid |
| bdbm115127 |
| cid_361510 |
| CHEBI:93655 |
| 4,5,7-trihydroxyanthraquinone-2-carboxylic acid |
| Q27165344 |
| 4,5,7-trihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid |
| CS-0136365 |
| HY-134000 |
| AKOS040734875 |
| Class | Description |
|---|---|
| trihydroxyanthraquinone | A member of the class of hydroxyanthraquinones carrying three hydroxy substituents. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 14.2114 | 0.0032 | 45.4673 | 12,589.2998 | AID2517; AID2572; AID2573 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 8.1548 | 0.0040 | 23.8416 | 100.0000 | AID485290 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.7407 | 0.1409 | 11.1940 | 39.8107 | AID2451 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 0.6310 | 35.7641 | 100.0000 | AID504339 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 35.4813 | 0.1259 | 19.1169 | 125.8920 | AID2549 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 21.3313 | 0.0072 | 15.7588 | 89.3584 | AID588342 |
| endonuclease IV | Escherichia coli | Potency | 10.0000 | 0.7079 | 12.4324 | 31.6228 | AID2565 |
| WRN | Homo sapiens (human) | Potency | 63.0957 | 0.1683 | 31.2583 | 100.0000 | AID651768 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 10.0000 | 0.1413 | 37.9142 | 100.0000 | AID1490 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 45.8577 | 0.0316 | 37.5844 | 354.8130 | AID504865; AID743255 |
| GLS protein | Homo sapiens (human) | Potency | 17.7828 | 0.3548 | 7.9355 | 39.8107 | AID624170 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.7882 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.5303 | 0.1800 | 13.5574 | 39.8107 | AID1460 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 0.1000 | 22.9075 | 100.0000 | AID485364 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 8.9125 | 0.7079 | 12.1943 | 39.8107 | AID720542 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.7530 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 17.7828 | 0.8913 | 10.4328 | 20.5750 | AID1379 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 0.7079 | 36.9043 | 89.1251 | AID504333 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 17.7828 | 0.3981 | 13.7447 | 31.6228 | AID1721; AID1722 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 0.0018 | 15.6638 | 39.8107 | AID894 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 20.5962 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 17.7828 | 0.0401 | 7.4590 | 31.6228 | AID1631; AID1634 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 7.9433 | 0.0224 | 21.0102 | 89.1251 | AID485314 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 27.0050 | 0.0398 | 16.7842 | 39.8107 | AID1454; AID995 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 40.0362 | 0.1337 | 25.4129 | 89.1251 | AID588795; AID720498 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 29.9349 | 0.1683 | 16.4040 | 67.0158 | AID720504 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 11.2202 | 0.4256 | 12.0591 | 28.1838 | AID504891 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 7.4623 | 0.1000 | 28.9256 | 213.3130 | AID588591; AID720502 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 16.8908 | 0.0501 | 27.0736 | 89.1251 | AID588590; AID720496 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 11.2202 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 11.2202 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 11.2202 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 8.7649 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 2.5119 | 0.0752 | 15.2253 | 39.8107 | AID485360 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 50.9100 | 0.0316 | 22.3146 | 100.0000 | AID588579 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 0.0041 | 9.9625 | 28.1838 | AID2675 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 50.1187 | 6.3096 | 60.2008 | 112.2020 | AID720709 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 0.0141 | 8.6024 | 39.8107 | AID2572 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 0.0015 | 51.7393 | 15,848.9004 | AID2572 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 0.0141 | 8.6024 | 39.8107 | AID2572 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 0.0141 | 8.6024 | 39.8107 | AID2572 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 0.5623 | 15.1609 | 31.6228 | AID1721 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 0.5623 | 15.1609 | 31.6228 | AID1721 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 50.1187 | 3.9811 | 46.7448 | 112.2020 | AID720708 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 17.7828 | 0.0757 | 8.4742 | 29.0628 | AID602233 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| integrase, partial | Human immunodeficiency virus 1 | IC50 (µMol) | 4.3025 | 0.0795 | 3.5203 | 9.9390 | AID1053171; AID1053172 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 (µMol) | 4.3025 | 0.0795 | 3.5203 | 9.9390 | AID1053171; AID1053172 |
| Accessory gene regulator protein A | Staphylococcus aureus | IC50 (µMol) | 30.6000 | 6.0000 | 7.0500 | 8.1000 | AID1155420 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| guanyl-nucleotide exchange factor activity | Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) |
| protein binding | Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) |
| protein domain specific binding | Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) |
| cAMP binding | Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) |
| guanyl-nucleotide exchange factor activity | Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) |
| protein binding | Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) |
| cAMP binding | Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) |
| protein-macromolecule adaptor activity | Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) |
| small GTPase binding | Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID67317 | Inhibitory activity against Human Leukocyte Elastase (HLE) at 58 uM concentration | 1992 | Journal of medicinal chemistry, May-01, Volume: 35, Issue:9 | Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. |
| AID477205 | Cytotoxicity against human NCI/ADR-RES cells at 5.2 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID477212 | Antibacterial activity against Pseudomonas aeruginosa after 18 hrs by microdilution broth method | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID477206 | Cytotoxicity against human PANC1 cells at 5.2 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID477203 | Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID477201 | Antifungal activity against Candida albicans after 18 hrs by microdilution broth method | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID477210 | Antibacterial activity against Staphylococcus aureus after 18 hrs by microdilution broth method | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID1155420 | Inhibition of AGR quorum sensing system in methicillin-resistant Staphylococcus aureus AH2759 incubated for 15 hrs by P3-LUX reporter gene assay | 2014 | Journal of natural products, Jun-27, Volume: 77, Issue:6 | Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. |
| AID477204 | Cytotoxicity against human DLD1 cells at 6.4 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID67648 | Inhibitory activity against Porcine Pancreatic Elastase (PPE) at 58 uM concentration | 1992 | Journal of medicinal chemistry, May-01, Volume: 35, Issue:9 | Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. |
| AID477202 | Cytotoxicity against human PANC1 cells at 6.4 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID477208 | Inhibition of human HDAC1 assessed as [3H]acetate release after 90 mins by scintillation counting | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID52621 | Inhibitory activity against Chymotrypsinogen at 58 uM concentration | 1992 | Journal of medicinal chemistry, May-01, Volume: 35, Issue:9 | Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. |
| AID477211 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 hrs by microdilution broth method | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID477207 | Cytotoxicity against human DLD1 cells at 5.2 uM after 48 hrs by MTT assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID1491207 | Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101. |
| AID1491209 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101. |
| AID1491210 | Anti-inflammatory activity in PMA/ionomycin stimulated human Jurkat T cells assessed as reduction in IL-2 secretion at 20 uM preincubated for 20 mins followed by PMA/ionomycin stimulation measured after 12 hrs by ELISA | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101. |
| AID1491208 | Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101. |
| AID48370 | Inhibitory activity against Cathepsin G (CatG) at 58 uM concentration | 1992 | Journal of medicinal chemistry, May-01, Volume: 35, Issue:9 | Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. |
| AID477209 | Inhibition of MCL1 binding to Bak by FRET assay | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.46) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (8.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (91.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||