cyclic amp, monosodium salt profile

ID Source	ID
PubMed CID	23669773
CHEMBL ID	1363683
MeSH ID	M0330718

Synonym
cyclic 3',5'-(hydrogen phosphate)adenosine monosodium salt
adenosine, cyclic 3',5'-(hydrogen phosphate)-, monosodium salt
cyclic 3',5'-amp sodium salt
cyclic amp sodium
3',5'-amp sodium salt
MLS001333135
adenosine 3',5'-cyclic monophosphate sodium salt monohydrate, >=98.0% (hplc), powder
37839-81-9
sodium(4ar,6r,7r,7as)-6-(6-amino-9h-purin-9-yl)-7-hydroxytetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
adenosine 3',5'-cyclic monophosphate monosodium salt
HMS2231C17
AKOS015916150
camp-na
(4ar,6r,7r,7as)-6-(6-amino-9h-purin-9-yl)-2,7-dihydroxytetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide, sodium salt
CHEMBL1363683
sodium;(4ar,6r,7r,7as)-6-(6-aminopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
AC-32412
adenosine-3',5'-cyclic monophosphate sodium salt
mfcd00069736
c-amp sodium salt
camp sodium salt
adenosine-3',5'-cyclic monophosphate monosodium salt
C74937
DTXSID30958868
sodium 6-(6-amino-9h-purin-9-yl)-7-hydroxy-2-oxotetrahydro-2h,4h-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate
CS-0136919
cyclic amp (sodium)
cyclic amp sodium salt
sodium (4ar,6r,7r,7as)-6-(6-amino-9h-purin-9-yl)-7-hydroxy-2-oxo-hexahydro-2-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate
HY-B1511A

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
ATAD5 protein, partial	Homo sapiens (human)	Potency	14.2655	0.0041	10.8903	31.5287	AID504466; AID504467
vasopressin V1b receptor	Homo sapiens (human)	Potency	0.1944	0.1944	16.0180	43.6206	AID492948
geminin	Homo sapiens (human)	Potency	1.0000	0.0046	11.3741	33.4983	AID624297
relaxin receptor 1 isoform 1	Homo sapiens (human)	Potency	0.5248	0.0388	14.3501	43.6206	AID2676; AID489012; AID492949
relaxin receptor 2 isoform 1	Homo sapiens (human)	Potency	0.2181	0.0488	15.9801	48.9431	AID489043
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	11.2947	6.3096	60.2008	112.2020	AID720707; AID720709
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	0.7943	1.9953	25.5327	50.1187	AID624288
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	13.5345	3.9811	46.7448	112.2020	AID720708; AID720711
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cAMP-dependent protein kinase type I-alpha regulatory subunit	Bos taurus (cattle)	EC50 (µMol)	0.0680	0.0680	4.1240	7.8270	AID504887; AID504896
cAMP-dependent protein kinase type II-beta regulatory subunit	Homo sapiens (human)	EC50 (µMol)	0.0885	0.0885	2.5405	5.3780	AID504888; AID504893
cAMP-dependent protein kinase catalytic subunit beta isoform 1	Mus musculus (house mouse)	EC50 (µMol)	0.0680	0.0680	4.1240	7.8270	AID504887; AID504896
cAMP-dependent protein kinase catalytic subunit beta isoform 3	Homo sapiens (human)	EC50 (µMol)	0.0885	0.0885	2.5405	5.3780	AID504888; AID504893
Cyclic nucleotide-gated channel beta subunit	Rattus norvegicus (Norway rat)	EC50 (µMol)	4.9800	4.9800	4.9800	4.9800	AID1603246
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	EC50 (µMol)	5.6200	5.6200	5.6200	5.6200	AID1603251
Cyclic nucleotide-gated olfactory channel	Rattus norvegicus (Norway rat)	EC50 (µMol)	29.0400	4.9800	4.9800	4.9800	AID1603246; AID1603247
Cyclic nucleotide-gated cation channel alpha-4	Rattus norvegicus (Norway rat)	EC50 (µMol)	4.9800	4.9800	4.9800	4.9800	AID1603246
Rap guanine nucleotide exchange factor 4	Mus musculus (house mouse)	EC50 (µMol)	3.8700	3.8700	3.8700	3.8700	AID1603252
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)	Kact	0.1330	0.1330	0.1330	0.1330	AID1603249
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kact	0.2440	0.2440	0.2440	0.2440	AID1603250
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
adaptive immune response	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
associative learning	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
Rap protein signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of actin cytoskeleton organization	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
intracellular signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of GTPase activity	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of protein export from nucleus	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of stress fiber assembly	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
establishment of endothelial barrier	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cellular response to cAMP	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
Ras protein signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of insulin secretion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
negative regulation of gene expression	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
mesoderm formation	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
regulation of protein phosphorylation	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
regulation of transcription by RNA polymerase II	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
positive regulation of insulin secretion	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
intracellular signal transduction	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
sarcomere organization	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
negative regulation of activated T cell proliferation	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cardiac muscle cell proliferation	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cellular response to glucagon stimulus	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
negative regulation of cAMP/PKA signal transduction	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
negative regulation of cAMP-dependent protein kinase activity	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
regulation of protein phosphorylation	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
intracellular signal transduction	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
negative regulation of cAMP/PKA signal transduction	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
negative regulation of cAMP-dependent protein kinase activity	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
adaptive immune response	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
calcium-ion regulated exocytosis	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
regulation of exocytosis	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
insulin secretion	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
positive regulation of insulin secretion	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
regulation of synaptic vesicle cycle	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
Ras protein signal transduction	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
regulation of insulin secretion	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
guanyl-nucleotide exchange factor activity	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein domain specific binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cAMP binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cAMP-dependent protein kinase inhibitor activity	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
protein binding	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase regulator activity	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
protein domain specific binding	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
ubiquitin protein ligase binding	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
protein kinase A catalytic subunit binding	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cAMP binding	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase inhibitor activity	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase regulator activity	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein domain specific binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
ubiquitin protein ligase binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein kinase A catalytic subunit binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cAMP binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
guanyl-nucleotide exchange factor activity	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
protein binding	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
cAMP binding	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
protein-macromolecule adaptor activity	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
small GTPase binding	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cortical actin cytoskeleton	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
microvillus	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
endomembrane system	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
lamellipodium	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
filopodium	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
extracellular exosome	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
immunological synapse	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
axoneme	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cytoplasm	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
multivesicular body	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
centrosome	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
membrane	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
neuromuscular junction	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
plasma membrane raft	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
sperm connecting piece	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
ciliary base	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
glutamatergic synapse	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
nucleotide-activated protein kinase complex	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
protein-containing complex	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase complex	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (human)
axoneme	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cytoplasm	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
centrosome	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
plasma membrane	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
focal adhesion	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
membrane	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
plasma membrane raft	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
extracellular exosome	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
ciliary base	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase complex	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
nucleotide-activated protein kinase complex	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein-containing complex	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
plasma membrane	Cyclic nucleotide-gated olfactory channel	Rattus norvegicus (Norway rat)
plasma membrane	Cyclic nucleotide-gated cation channel alpha-4	Rattus norvegicus (Norway rat)
cytosol	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
membrane	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (29)

Assay ID	Title	Year	Journal	Article
AID1603246	Activation of recombinant rat CNGA2/CNGA4/CNGB1b heterotetramer expressed in Xenopus laevis oocyte assessed as increase in current amplitude by patch-clamp electrophysiology method	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID1603251	Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by fluorescence polarization assay	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID1603250	Activation of recombinant human PKAR2alpha expressed in Escherichia coli using Kemptide as substrate by spectrophotometric method	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID1603248	Activation of recombinant mouse HCN2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude at -30 mV holding potential by patch-clamp electrophysiology method	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID1603252	Inhibition of 8Fluo-cAMP binding to DEP domain deficient mouse EPAC2 (280 to 988 residues) measured after 5 mins by fluorescence polarization assay	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID1603249	Activation of recombinant human PKAR1alpha expressed in Escherichia coli using Kemptide as substrate by spectrophotometric method	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID1145897	Induction of radioiodine secretion from 14 days iodine-poor diet fed mouse thyroid assessed as blood [125I] level at 60 mg/kg, iv after 2 hrs pretreated with 10 ug L-thyroxine and [125-I] relative to control by McKenzie Bioassay	1976	Journal of medicinal chemistry, Jul, Volume: 19, Issue:7	Synthesis of new cyclic nucleotides and their differential stimulatory effects on thyroid function in mice.
AID1603247	Activation of recombinant rat CNGA2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude by patch-clamp electrophysiology method	2019	Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8	Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.
AID504888	Fluorescence polarization-based biochemical high throughput dose response assay for activators of the Protein Kinase A-R2B (PKA-R2B) complex	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504796	Counterscreen for activators of the Protein Kinase A-R2B (PKA-R2B) complex: fluorescence polarization-based biochemical high throughput screening assay to identify fluorescence polarization assay artifacts	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID504890	Counterscreen for activators of the Protein Kinase A-R2B (PKA-R2B) complex: fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescence polarization assay artifacts	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID504887	Fluorescence polarization-based biochemical high throughput dose response assay for activators of the Protein Kinase A-R1A (PKA-R1A) complex	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID504896	Counterscreen for activators of the Protein Kinase A-R2B (PKA-R2B) complex: fluorescence polarization-based biochemical high throughput dose response assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504883	Counterscreen for activators of the Protein Kinase A-R1A (PKA-R1A) complex: fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescence polarization assay artifacts	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504800	Fluorescence polarization-based biochemical high throughput confirmation assay for activators of the Protein Kinase A-R1A (PKA-R1A) complex	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID504799	Counterscreen for activators of the Protein Kinase A-R1A (PKA-R1A) complex: fluorescence polarization-based biochemical high throughput screening assay to identify fluorescence polarization assay artifacts	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID504893	Counterscreen for activators of the Protein Kinase A-R1A (PKA-R1A) complex: fluorescence polarization-based biochemical high throughput dose response assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complex	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID504797	Fluorescence polarization-based biochemical high throughput confirmation assay for activators of the Protein Kinase A-R2B (PKA-R2B) complex	2006	Analytical chemistry, Dec-15, Volume: 78, Issue:24	Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	3 (42.86)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cyclobutane-1,1-dicarboxylic acid [no description available]	2.03	1	cyclobutanedicarboxylic acid
flurbiprofen Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.. flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.	2.03	1	fluorobiphenyl; monocarboxylic acid	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
quinethazone quinethazone: RN given for cpd without isomeric designation. quinethazone : A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension.	2.03	1	quinazolines	antihypertensive agent; diuretic
n,n,n',n'-tetramethyl-4,4'-methylenedianiline N,N,N',N'-tetramethyl-4,4'-methylenedianiline: structure given in first source	2.03	1	diarylmethane
sulfan blue sulfan blue: widely used to visualize lymph vessels for lymphography; structure	2.03	1	organic molecular entity
2-thymotic acid 2-thymotic acid: RN given refers to parent cpd; structure	2.03	1	monoterpenoid
buspirone hydrochloride buspirone hydrochloride : A hydrochloride salt resulting from the reaction of equimolar amounts of buspirone and hydrogen chloride.	2.03	1	hydrochloride	anxiolytic drug; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; sedative; serotonergic agonist
e-250 [no description available]	2.03	1
4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol: structure in first source	2.03	1	piperidines
ici 204448 [no description available]	2.03	1
tosifen [no description available]	2.03	1
2-[[5-(phenoxymethyl)-4-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetamide [no description available]	2.03	1	aromatic ether
N-[2-[2-[2-(4-methoxyanilino)-2-oxoethyl]-5-tetrazolyl]phenyl]-2-furancarboxamide [no description available]	2.03	1	aromatic amide; furans
2-[[4-amino-5-(4-tert-butylphenyl)-1,2,4-triazol-3-yl]thio]acetic acid propan-2-yl ester [no description available]	2.03	1	isopropyl ester; triazoles
5-(3,5-dimethoxyphenyl)-3-(2-methoxyphenyl)-1,2,4-oxadiazole [no description available]	2.03	1	oxadiazole; ring assembly
pseudoginsenoside f11 [no description available]	2.03	1
8-methyl-2-phenyl-1,2,4-triazaspiro[4.5]decane-3-thione [no description available]	2.03	1	benzenes
N-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]carbamic acid phenyl ester [no description available]	2.03	1	piperazines
2-[[2-(3,5-dimethyl-1-pyrazolyl)-6-methyl-4-pyrimidinyl]amino]ethanol [no description available]	2.03	1	aminopyrimidine
2-chloro-N-(2-phenyl-5-propyl-3-pyrazolyl)acetamide [no description available]	2.03	1	pyrazoles; ring assembly
2-[[(6-chloro-4-oxo-3-prop-2-enyl-2-quinazolinyl)thio]methyl]isoindole-1,3-dione [no description available]	2.03	1	phthalimides
5-(2-oxolanylmethylamino)-2-thiophen-2-yl-4-oxazolecarbonitrile [no description available]	2.03	1	oxazole
2-(benzenesulfonamido)-N-[(2-methoxyphenyl)methyl]propanamide [no description available]	2.03	1	amino acid amide
4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester [no description available]	2.03	1	oxopurine
3-(2-methoxyphenyl)-2-methyl-4-oxo-1H-quinazoline-2-carboxylic acid methyl ester [no description available]	2.03	1	quinazolines
4-ethylbenzoic acid [2-(2-ethoxyanilino)-2-oxo-1-phenylethyl] ester [no description available]	2.03	1	benzoate ester
N-(3,4-dimethylphenyl)-4-oxo-3,10-dihydro-2H-pyrimido[1,2-a]benzimidazole-2-carboxamide [no description available]	2.03	1	organonitrogen compound; organooxygen compound
nalbuphine hydrochloride [no description available]	2.03	1	hydrochloride
(2R,4R)-N-(1H-benzimidazol-2-ylmethyl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-pyran-6-carboxamide [no description available]	2.03	1	(trifluoromethyl)benzenes
2-imino-8-methyl-5-oxo-1-(2-oxolanylmethyl)-N-(2-phenylethyl)-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamide [no description available]	2.03	1	pyridopyrimidine
2-[[4-(3-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol [no description available]	2.03	1	methoxybenzenes; substituted aniline
bucladesine Bucladesine: A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed). bucladesine : A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.	2.38	2	3',5'-cyclic purine nucleotide
N-[5-[[2-(4-acetamidoanilino)-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]-3-methoxybenzamide [no description available]	2.03	1	acetamides; anilide
3-(2,5-dimethoxyphenyl)-6-[4-methoxy-3-(3-oxolanyloxy)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine [no description available]	2.03	1	triazoles
8-bromocyclic gmp, sodium salt sodium 8-bromo-3',5'-cyclic GMP : An organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.	2.03	1	organic sodium salt	muscle relaxant; protein kinase G agonist

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

cyclic amp, monosodium salt

Cross-References

Synonyms (30)

Protein Targets (18)

Potency Measurements

Activation Measurements

Other Measurements

Biological Processes (38)

Molecular Functions (12)

Ceullar Components (24)

Bioassays (29)

Research

Studies (7)

Market Indicators

Research Demand Index: 11.98

Study Types

cyclic amp, monosodium salt

Cross-References

Synonyms (30)

Protein Targets (18)

Potency Measurements

Activation Measurements

Other Measurements

Biological Processes (38)

Molecular Functions (12)

Ceullar Components (24)

Bioassays (29)

Research

Studies (7)

Market Indicators

Research Demand Index: 11.98

Study Types

Related Drugs (35)

Related Conditions (2)